Effect of Novel Polymer-Free Nitrogen-Doped Titanium Dioxide Film–Coated Coronary Stent Loaded With Mycophenolic Acid
Background: Titanium is commonly used in blood-exposed medical devices because it has superior blood compatibility. Mycophenolic acid inhibits the proliferation of vascular smooth muscle cells. This study examined the effect of a non-polymer TiO2 thin film–coated stent with mycophenolic acid in a po...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2021.650408/full |
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| author | Jae Won Shim Jae Won Shim Sung Soo Kim Hyun Kuk Kim In Ho Bae In Ho Bae Dae Sung Park Dae Sung Park Dae Sung Park Jun-Kyu Park Jae Un Kim Jae Un Kim Han Byul Kim Min Young Lee Joong Sun Kim Jung Ha Kim Jung Ha Kim Bon-Sang Koo Kang-Jin Jeong Sun-Uk Kim Min Chul Kim Doo Sun Sim Young Joon Hong Youngkeun Ahn Kyung Seob Lim Myung Ho Jeong Myung Ho Jeong |
| author_facet | Jae Won Shim Jae Won Shim Sung Soo Kim Hyun Kuk Kim In Ho Bae In Ho Bae Dae Sung Park Dae Sung Park Dae Sung Park Jun-Kyu Park Jae Un Kim Jae Un Kim Han Byul Kim Min Young Lee Joong Sun Kim Jung Ha Kim Jung Ha Kim Bon-Sang Koo Kang-Jin Jeong Sun-Uk Kim Min Chul Kim Doo Sun Sim Young Joon Hong Youngkeun Ahn Kyung Seob Lim Myung Ho Jeong Myung Ho Jeong |
| author_sort | Jae Won Shim |
| collection | DOAJ |
| description | Background: Titanium is commonly used in blood-exposed medical devices because it has superior blood compatibility. Mycophenolic acid inhibits the proliferation of vascular smooth muscle cells. This study examined the effect of a non-polymer TiO2 thin film–coated stent with mycophenolic acid in a porcine coronary overstretch restenosis model.Methods: Thirty coronary arteries in 15 pigs were randomized into three groups in which the coronary arteries were treated with a TiO2 film–coated stent with mycophenolic acid (NTM, n = 10), everolimus-eluting stent with biodegradable polymer (EES, n = 10), or TiO2 film–coated stent (NT, n = 10). A histopathologic analysis was performed 28 days after the stenting.Results: There were no significant intergroup differences in injury score, internal elastic lamina area, or inflammation score. Percent area stenosis was significantly smaller in the NTM and EES groups than in the NT group (36.1 ± 13.63% vs. 31.6 ± 7.74% vs. 45.5 ± 18.96%, respectively, p = 0.0003). Fibrin score was greater in the EES group than in the NTM and NT groups [2.0 (range, 2.0–2.0) vs. 1.0 (range, 1.0–1.75) vs. 1.0 (range, 1.0–1.0), respectively, p < 0.0001]. The in-stent occlusion rate measured by micro-computed tomography demonstrated similar percent area stenosis rates on histology analysis (36.1 ± 15.10% in NTM vs. 31.6 ± 8.89% in EES vs. 45.5 ± 17.26% in NT, p < 0.05).Conclusion: The NTM more effectively reduced neointima proliferation than the NT. Moreover, the inhibitory effect of NTM on smooth muscle cell proliferation was not inferior to that of the polymer-based EES with lower fibrin deposition in this porcine coronary restenosis model. |
| first_indexed | 2024-12-20T02:48:26Z |
| format | Article |
| id | doaj.art-5618a1001739438ea6ca54e4462a635d |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-20T02:48:26Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-5618a1001739438ea6ca54e4462a635d2022-12-21T19:56:06ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852021-10-01910.3389/fbioe.2021.650408650408Effect of Novel Polymer-Free Nitrogen-Doped Titanium Dioxide Film–Coated Coronary Stent Loaded With Mycophenolic AcidJae Won Shim0Jae Won Shim1Sung Soo Kim2Hyun Kuk Kim3In Ho Bae4In Ho Bae5Dae Sung Park6Dae Sung Park7Dae Sung Park8Jun-Kyu Park9Jae Un Kim10Jae Un Kim11Han Byul Kim12Min Young Lee13Joong Sun Kim14Jung Ha Kim15Jung Ha Kim16Bon-Sang Koo17Kang-Jin Jeong18Sun-Uk Kim19Min Chul Kim20Doo Sun Sim21Young Joon Hong22Youngkeun Ahn23Kyung Seob Lim24Myung Ho Jeong25Myung Ho Jeong26Korea Cardiovascular Stent Research Institute, Jangsung, South KoreaCardiovascular Research Center, Chonnam National University Hospital, Gwangju, South KoreaDivision of Cardiology, Chosun University Hospital, Gwangju, South KoreaDivision of Cardiology, Chosun University Hospital, Gwangju, South KoreaKorea Cardiovascular Stent Research Institute, Jangsung, South KoreaCardiovascular Research Center, Chonnam National University Hospital, Gwangju, South KoreaKorea Cardiovascular Stent Research Institute, Jangsung, South KoreaCardiovascular Research Center, Chonnam National University Hospital, Gwangju, South KoreaResearch Institute of Medical Sciences, Chonnam National University, Gwangju, South KoreaCGBio. Co. Ltd., Jangsung, South KoreaKorea Cardiovascular Stent Research Institute, Jangsung, South KoreaCardiovascular Research Center, Chonnam National University Hospital, Gwangju, South KoreaCardiovascular Research Center, Chonnam National University Hospital, Gwangju, South KoreaCollege of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, South KoreaCollege of Veterinary Medicine, Chonnam National University, Gwangju, South KoreaKorea Cardiovascular Stent Research Institute, Jangsung, South KoreaCardiovascular Research Center, Chonnam National University Hospital, Gwangju, South KoreaFuturistic Animal Resource and Research Center, National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk, South KoreaFuturistic Animal Resource and Research Center, National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk, South KoreaFuturistic Animal Resource and Research Center, National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk, South KoreaFuturistic Animal Resource and Research Center, National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk, South KoreaCardiovascular Research Center, Chonnam National University Hospital, Gwangju, South KoreaCardiovascular Research Center, Chonnam National University Hospital, Gwangju, South KoreaCardiovascular Research Center, Chonnam National University Hospital, Gwangju, South KoreaFuturistic Animal Resource and Research Center, National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk, South KoreaKorea Cardiovascular Stent Research Institute, Jangsung, South KoreaCardiovascular Research Center, Chonnam National University Hospital, Gwangju, South KoreaBackground: Titanium is commonly used in blood-exposed medical devices because it has superior blood compatibility. Mycophenolic acid inhibits the proliferation of vascular smooth muscle cells. This study examined the effect of a non-polymer TiO2 thin film–coated stent with mycophenolic acid in a porcine coronary overstretch restenosis model.Methods: Thirty coronary arteries in 15 pigs were randomized into three groups in which the coronary arteries were treated with a TiO2 film–coated stent with mycophenolic acid (NTM, n = 10), everolimus-eluting stent with biodegradable polymer (EES, n = 10), or TiO2 film–coated stent (NT, n = 10). A histopathologic analysis was performed 28 days after the stenting.Results: There were no significant intergroup differences in injury score, internal elastic lamina area, or inflammation score. Percent area stenosis was significantly smaller in the NTM and EES groups than in the NT group (36.1 ± 13.63% vs. 31.6 ± 7.74% vs. 45.5 ± 18.96%, respectively, p = 0.0003). Fibrin score was greater in the EES group than in the NTM and NT groups [2.0 (range, 2.0–2.0) vs. 1.0 (range, 1.0–1.75) vs. 1.0 (range, 1.0–1.0), respectively, p < 0.0001]. The in-stent occlusion rate measured by micro-computed tomography demonstrated similar percent area stenosis rates on histology analysis (36.1 ± 15.10% in NTM vs. 31.6 ± 8.89% in EES vs. 45.5 ± 17.26% in NT, p < 0.05).Conclusion: The NTM more effectively reduced neointima proliferation than the NT. Moreover, the inhibitory effect of NTM on smooth muscle cell proliferation was not inferior to that of the polymer-based EES with lower fibrin deposition in this porcine coronary restenosis model.https://www.frontiersin.org/articles/10.3389/fbioe.2021.650408/fullstentsmyocophenolic acidcoronary arterytitanium coatingpercutaneous coronary interventionrestenosis |
| spellingShingle | Jae Won Shim Jae Won Shim Sung Soo Kim Hyun Kuk Kim In Ho Bae In Ho Bae Dae Sung Park Dae Sung Park Dae Sung Park Jun-Kyu Park Jae Un Kim Jae Un Kim Han Byul Kim Min Young Lee Joong Sun Kim Jung Ha Kim Jung Ha Kim Bon-Sang Koo Kang-Jin Jeong Sun-Uk Kim Min Chul Kim Doo Sun Sim Young Joon Hong Youngkeun Ahn Kyung Seob Lim Myung Ho Jeong Myung Ho Jeong Effect of Novel Polymer-Free Nitrogen-Doped Titanium Dioxide Film–Coated Coronary Stent Loaded With Mycophenolic Acid Frontiers in Bioengineering and Biotechnology stents myocophenolic acid coronary artery titanium coating percutaneous coronary intervention restenosis |
| title | Effect of Novel Polymer-Free Nitrogen-Doped Titanium Dioxide Film–Coated Coronary Stent Loaded With Mycophenolic Acid |
| title_full | Effect of Novel Polymer-Free Nitrogen-Doped Titanium Dioxide Film–Coated Coronary Stent Loaded With Mycophenolic Acid |
| title_fullStr | Effect of Novel Polymer-Free Nitrogen-Doped Titanium Dioxide Film–Coated Coronary Stent Loaded With Mycophenolic Acid |
| title_full_unstemmed | Effect of Novel Polymer-Free Nitrogen-Doped Titanium Dioxide Film–Coated Coronary Stent Loaded With Mycophenolic Acid |
| title_short | Effect of Novel Polymer-Free Nitrogen-Doped Titanium Dioxide Film–Coated Coronary Stent Loaded With Mycophenolic Acid |
| title_sort | effect of novel polymer free nitrogen doped titanium dioxide film coated coronary stent loaded with mycophenolic acid |
| topic | stents myocophenolic acid coronary artery titanium coating percutaneous coronary intervention restenosis |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2021.650408/full |
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