The role of angiotensin receptor blockers in reducing the risk of cardiovascular disease
New approaches to the definition and treatment of hypertension have increased emphasis on reducing overall cardiovascular risk and on targeting the underlying mechanisms of cardiovascular disease. During the past several decades, renin–angiotensin–aldosterone system (RAAS) activation has emerged as...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2012-09-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320312443910 |
| _version_ | 1797288161958690816 |
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| author | Dmitry Abramov Peter E Carson |
| author_facet | Dmitry Abramov Peter E Carson |
| author_sort | Dmitry Abramov |
| collection | DOAJ |
| description | New approaches to the definition and treatment of hypertension have increased emphasis on reducing overall cardiovascular risk and on targeting the underlying mechanisms of cardiovascular disease. During the past several decades, renin–angiotensin–aldosterone system (RAAS) activation has emerged as an important factor in the pathophysiology of endothelial dysfunction and cardiovascular disease (CVD). Angiotensin-converting enzyme inhibitors (ACEIs) have well-established efficacy for treating CVD, but their use may be limited by intolerable side effects, such as cough and angioedema. Angiotensin II receptor blockers (ARBs), a different class of RAAS inhibitors, are considered a viable alternative to ACEIs. Clinical trials have further elucidated the role of ARBs in CVD. This article reviews the mechanism of action of ARBs and selected clinical trials of ARBs in CVD. |
| first_indexed | 2024-03-07T18:44:22Z |
| format | Article |
| id | doaj.art-561eb2a5a91447ed92ed437081307caf |
| institution | Directory Open Access Journal |
| issn | 1470-3203 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T18:44:22Z |
| publishDate | 2012-09-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-561eb2a5a91447ed92ed437081307caf2024-03-02T02:47:16ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762012-09-011310.1177/1470320312443910The role of angiotensin receptor blockers in reducing the risk of cardiovascular diseaseDmitry AbramovPeter E CarsonNew approaches to the definition and treatment of hypertension have increased emphasis on reducing overall cardiovascular risk and on targeting the underlying mechanisms of cardiovascular disease. During the past several decades, renin–angiotensin–aldosterone system (RAAS) activation has emerged as an important factor in the pathophysiology of endothelial dysfunction and cardiovascular disease (CVD). Angiotensin-converting enzyme inhibitors (ACEIs) have well-established efficacy for treating CVD, but their use may be limited by intolerable side effects, such as cough and angioedema. Angiotensin II receptor blockers (ARBs), a different class of RAAS inhibitors, are considered a viable alternative to ACEIs. Clinical trials have further elucidated the role of ARBs in CVD. This article reviews the mechanism of action of ARBs and selected clinical trials of ARBs in CVD.https://doi.org/10.1177/1470320312443910 |
| spellingShingle | Dmitry Abramov Peter E Carson The role of angiotensin receptor blockers in reducing the risk of cardiovascular disease Journal of the Renin-Angiotensin-Aldosterone System |
| title | The role of angiotensin receptor blockers in reducing the risk of cardiovascular disease |
| title_full | The role of angiotensin receptor blockers in reducing the risk of cardiovascular disease |
| title_fullStr | The role of angiotensin receptor blockers in reducing the risk of cardiovascular disease |
| title_full_unstemmed | The role of angiotensin receptor blockers in reducing the risk of cardiovascular disease |
| title_short | The role of angiotensin receptor blockers in reducing the risk of cardiovascular disease |
| title_sort | role of angiotensin receptor blockers in reducing the risk of cardiovascular disease |
| url | https://doi.org/10.1177/1470320312443910 |
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