Towards understanding centriole elimination
Centrioles are microtubule-based structures crucial for forming flagella, cilia and centrosomes. Through these roles, centrioles are critical notably for proper cell motility, signalling and division. Recent years have advanced significantly our understanding of the mechanisms governing centriole as...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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The Royal Society
2023-11-01
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| Series: | Open Biology |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/10.1098/rsob.230222 |
| _version_ | 1797361001118564352 |
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| author | Nils Kalbfuss Pierre Gönczy |
| author_facet | Nils Kalbfuss Pierre Gönczy |
| author_sort | Nils Kalbfuss |
| collection | DOAJ |
| description | Centrioles are microtubule-based structures crucial for forming flagella, cilia and centrosomes. Through these roles, centrioles are critical notably for proper cell motility, signalling and division. Recent years have advanced significantly our understanding of the mechanisms governing centriole assembly and architecture. Although centrioles are typically very stable organelles, persisting over many cell cycles, they can also be eliminated in some cases. Here, we review instances of centriole elimination in a range of species and cell types. Moreover, we discuss potential mechanisms that enable the switch from a stable organelle to a vanishing one. Further work is expected to provide novel insights into centriole elimination mechanisms in health and disease, thereby also enabling scientists to readily manipulate organelle fate. |
| first_indexed | 2024-03-08T15:47:41Z |
| format | Article |
| id | doaj.art-5622a901ee444beb818cf416b26b4f57 |
| institution | Directory Open Access Journal |
| issn | 2046-2441 |
| language | English |
| last_indexed | 2024-03-08T15:47:41Z |
| publishDate | 2023-11-01 |
| publisher | The Royal Society |
| record_format | Article |
| series | Open Biology |
| spelling | doaj.art-5622a901ee444beb818cf416b26b4f572024-01-09T09:30:51ZengThe Royal SocietyOpen Biology2046-24412023-11-01131110.1098/rsob.230222Towards understanding centriole eliminationNils Kalbfuss0Pierre Gönczy1Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, SwitzerlandSwiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), 1015 Lausanne, SwitzerlandCentrioles are microtubule-based structures crucial for forming flagella, cilia and centrosomes. Through these roles, centrioles are critical notably for proper cell motility, signalling and division. Recent years have advanced significantly our understanding of the mechanisms governing centriole assembly and architecture. Although centrioles are typically very stable organelles, persisting over many cell cycles, they can also be eliminated in some cases. Here, we review instances of centriole elimination in a range of species and cell types. Moreover, we discuss potential mechanisms that enable the switch from a stable organelle to a vanishing one. Further work is expected to provide novel insights into centriole elimination mechanisms in health and disease, thereby also enabling scientists to readily manipulate organelle fate.https://royalsocietypublishing.org/doi/10.1098/rsob.230222centriole maintenancecentriole eliminationcentriole repairorganelle degradation |
| spellingShingle | Nils Kalbfuss Pierre Gönczy Towards understanding centriole elimination Open Biology centriole maintenance centriole elimination centriole repair organelle degradation |
| title | Towards understanding centriole elimination |
| title_full | Towards understanding centriole elimination |
| title_fullStr | Towards understanding centriole elimination |
| title_full_unstemmed | Towards understanding centriole elimination |
| title_short | Towards understanding centriole elimination |
| title_sort | towards understanding centriole elimination |
| topic | centriole maintenance centriole elimination centriole repair organelle degradation |
| url | https://royalsocietypublishing.org/doi/10.1098/rsob.230222 |
| work_keys_str_mv | AT nilskalbfuss towardsunderstandingcentrioleelimination AT pierregonczy towardsunderstandingcentrioleelimination |