Identification of an Exon 4-Deletion Variant of Epidermal Growth Factor Receptor with Increased Metastasis-Promoting Capacity

Identification of an Exon 4-Deletion Variant of Epidermal Growth Factor Receptor with Increased Metastasis-Promoting Capacity

Several types of epidermal growth factor receptor (EGFR) gene alternations have been observed in human tumors. Here we present a novel EGFR variant with aberrant splicing of exon 4 (named as de4 EGFR). Variant-specific polymerase chain reaction showed that de4 EGFR was expressed in some glioma (4/40...

Full description

Bibliographic Details
Main Authors: Hai Wang, Min Zhou, Bizhi Shi, Qingli Zhang, Hua Jiang, Yinghao Sun, Jianhua Liu, Keke Zhou, Ming Yao, Jianren Gu, Shengli Yang, Ying Mao, Zonghai Li
Format: Article
Language:English
Published: Elsevier 2011-05-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558611800643

Internet

http://www.sciencedirect.com/science/article/pii/S1476558611800643

Similar Items