Beneficial Effect of Luteal-phase Gonadotropin-releasing Hormone Agonist Administration on Implantation Rate Afterintracytoplasmic Sperm Injection
Objective: To evaluate the effect of gonadotropin-releasing hormone (GnRH) agonist, administered in the luteal phase, on intracytoplasmic sperm injection (ICSI) outcome. Materials and Methods: One hundred and eighty women undergoing ovarian stimulation for ICSI were enrolled in this study. Patients...
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| Format: | Article |
| Language: | English |
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Elsevier
2009-09-01
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| Series: | Taiwanese Journal of Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1028455909602977 |
| _version_ | 1818043485297573888 |
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| author | Dehghani Firouzabadi Razieh Ayazi Rozbahani Maryam Tabibnejad Nasim |
| author_facet | Dehghani Firouzabadi Razieh Ayazi Rozbahani Maryam Tabibnejad Nasim |
| author_sort | Dehghani Firouzabadi Razieh |
| collection | DOAJ |
| description | Objective: To evaluate the effect of gonadotropin-releasing hormone (GnRH) agonist, administered in the luteal phase, on intracytoplasmic sperm injection (ICSI) outcome.
Materials and Methods: One hundred and eighty women undergoing ovarian stimulation for ICSI were enrolled in this study. Patients were randomly assigned to receive a single dose of GnRH agonist or placebo. Implantation rate and clinical pregnancy rate were the main outcomes.
Results: Administration of 0.1 mg of the GnRH agonist triptorelin on day 3 after embryo transfer led to a significant improvement in implantation rate (12.3% vs. 7.3%) and clinical pregnancy rate (25.5% vs. 10.0%) as compared with placebo.
Conclusion: Luteal phase GnRH agonist administration enhances ICSI clinical outcomes. |
| first_indexed | 2024-12-10T09:02:58Z |
| format | Article |
| id | doaj.art-56236a469b6643de996de62cfab63b66 |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-12-10T09:02:58Z |
| publishDate | 2009-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-56236a469b6643de996de62cfab63b662022-12-22T01:55:13ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592009-09-0148324524810.1016/S1028-4559(09)60297-7Beneficial Effect of Luteal-phase Gonadotropin-releasing Hormone Agonist Administration on Implantation Rate Afterintracytoplasmic Sperm InjectionDehghani Firouzabadi RaziehAyazi Rozbahani MaryamTabibnejad NasimObjective: To evaluate the effect of gonadotropin-releasing hormone (GnRH) agonist, administered in the luteal phase, on intracytoplasmic sperm injection (ICSI) outcome. Materials and Methods: One hundred and eighty women undergoing ovarian stimulation for ICSI were enrolled in this study. Patients were randomly assigned to receive a single dose of GnRH agonist or placebo. Implantation rate and clinical pregnancy rate were the main outcomes. Results: Administration of 0.1 mg of the GnRH agonist triptorelin on day 3 after embryo transfer led to a significant improvement in implantation rate (12.3% vs. 7.3%) and clinical pregnancy rate (25.5% vs. 10.0%) as compared with placebo. Conclusion: Luteal phase GnRH agonist administration enhances ICSI clinical outcomes.http://www.sciencedirect.com/science/article/pii/S1028455909602977embryo implantationGnRH agonistintracytoplasmic sperm injectionluteal phase support |
| spellingShingle | Dehghani Firouzabadi Razieh Ayazi Rozbahani Maryam Tabibnejad Nasim Beneficial Effect of Luteal-phase Gonadotropin-releasing Hormone Agonist Administration on Implantation Rate Afterintracytoplasmic Sperm Injection Taiwanese Journal of Obstetrics & Gynecology embryo implantation GnRH agonist intracytoplasmic sperm injection luteal phase support |
| title | Beneficial Effect of Luteal-phase Gonadotropin-releasing Hormone Agonist Administration on Implantation Rate Afterintracytoplasmic Sperm Injection |
| title_full | Beneficial Effect of Luteal-phase Gonadotropin-releasing Hormone Agonist Administration on Implantation Rate Afterintracytoplasmic Sperm Injection |
| title_fullStr | Beneficial Effect of Luteal-phase Gonadotropin-releasing Hormone Agonist Administration on Implantation Rate Afterintracytoplasmic Sperm Injection |
| title_full_unstemmed | Beneficial Effect of Luteal-phase Gonadotropin-releasing Hormone Agonist Administration on Implantation Rate Afterintracytoplasmic Sperm Injection |
| title_short | Beneficial Effect of Luteal-phase Gonadotropin-releasing Hormone Agonist Administration on Implantation Rate Afterintracytoplasmic Sperm Injection |
| title_sort | beneficial effect of luteal phase gonadotropin releasing hormone agonist administration on implantation rate afterintracytoplasmic sperm injection |
| topic | embryo implantation GnRH agonist intracytoplasmic sperm injection luteal phase support |
| url | http://www.sciencedirect.com/science/article/pii/S1028455909602977 |
| work_keys_str_mv | AT dehghanifirouzabadirazieh beneficialeffectoflutealphasegonadotropinreleasinghormoneagonistadministrationonimplantationrateafterintracytoplasmicsperminjection AT ayazirozbahanimaryam beneficialeffectoflutealphasegonadotropinreleasinghormoneagonistadministrationonimplantationrateafterintracytoplasmicsperminjection AT tabibnejadnasim beneficialeffectoflutealphasegonadotropinreleasinghormoneagonistadministrationonimplantationrateafterintracytoplasmicsperminjection |