Through the Looking Glass: Genome, Phenome, and Interactome of <i>Salmonella enterica</i>
This review revisits previous concepts on biological phenomenon contributing to the success of the <i>Salmonella enterica</i> subspecies I as a pathogen and expands upon them to include progress in epidemiology based on whole genome sequencing (WGS). Discussion goes beyond epidemiologica...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/11/5/581 |
| _version_ | 1797497011022331904 |
|---|---|
| author | Jean Guard |
| author_facet | Jean Guard |
| author_sort | Jean Guard |
| collection | DOAJ |
| description | This review revisits previous concepts on biological phenomenon contributing to the success of the <i>Salmonella enterica</i> subspecies I as a pathogen and expands upon them to include progress in epidemiology based on whole genome sequencing (WGS). Discussion goes beyond epidemiological uses of WGS to consider how phenotype, which is the biological character of an organism, can be correlated with its genotype to develop a knowledge of the interactome. Deciphering genome interactions with proteins, the impact of metabolic flux, epigenetic modifications, and other complex biochemical processes will lead to new therapeutics, control measures, environmental remediations, and improved design of vaccines. |
| first_indexed | 2024-03-10T03:11:22Z |
| format | Article |
| id | doaj.art-56237dde09574f20830f883768060116 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T03:11:22Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-56237dde09574f20830f8837680601162023-11-23T12:32:56ZengMDPI AGPathogens2076-08172022-05-0111558110.3390/pathogens11050581Through the Looking Glass: Genome, Phenome, and Interactome of <i>Salmonella enterica</i>Jean Guard0U. S. Department of Agriculture, Agricultural Research Service, U. S. National Poultry Research Center, 950 College Station Road, Athens, GA 30605, USAThis review revisits previous concepts on biological phenomenon contributing to the success of the <i>Salmonella enterica</i> subspecies I as a pathogen and expands upon them to include progress in epidemiology based on whole genome sequencing (WGS). Discussion goes beyond epidemiological uses of WGS to consider how phenotype, which is the biological character of an organism, can be correlated with its genotype to develop a knowledge of the interactome. Deciphering genome interactions with proteins, the impact of metabolic flux, epigenetic modifications, and other complex biochemical processes will lead to new therapeutics, control measures, environmental remediations, and improved design of vaccines.https://www.mdpi.com/2076-0817/11/5/581<i>Salmonella enterica</i>interactomephenotypegenotypeserotypespeciation |
| spellingShingle | Jean Guard Through the Looking Glass: Genome, Phenome, and Interactome of <i>Salmonella enterica</i> Pathogens <i>Salmonella enterica</i> interactome phenotype genotype serotype speciation |
| title | Through the Looking Glass: Genome, Phenome, and Interactome of <i>Salmonella enterica</i> |
| title_full | Through the Looking Glass: Genome, Phenome, and Interactome of <i>Salmonella enterica</i> |
| title_fullStr | Through the Looking Glass: Genome, Phenome, and Interactome of <i>Salmonella enterica</i> |
| title_full_unstemmed | Through the Looking Glass: Genome, Phenome, and Interactome of <i>Salmonella enterica</i> |
| title_short | Through the Looking Glass: Genome, Phenome, and Interactome of <i>Salmonella enterica</i> |
| title_sort | through the looking glass genome phenome and interactome of i salmonella enterica i |
| topic | <i>Salmonella enterica</i> interactome phenotype genotype serotype speciation |
| url | https://www.mdpi.com/2076-0817/11/5/581 |
| work_keys_str_mv | AT jeanguard throughthelookingglassgenomephenomeandinteractomeofisalmonellaentericai |