The Dangerous Liaisons in the Oxidative Stress Response to <i>Leishmania</i> Infection
<i>Leishmania</i> parasites preferentially invade macrophages, the professional phagocytic cells, at the site of infection. Macrophages play conflicting roles in <i>Leishmania</i> infection either by the destruction of internalized parasites or by providing a safe shelter for...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/11/4/409 |
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| author | Marta Reverte Tiia Snäkä Nicolas Fasel |
| author_facet | Marta Reverte Tiia Snäkä Nicolas Fasel |
| author_sort | Marta Reverte |
| collection | DOAJ |
| description | <i>Leishmania</i> parasites preferentially invade macrophages, the professional phagocytic cells, at the site of infection. Macrophages play conflicting roles in <i>Leishmania</i> infection either by the destruction of internalized parasites or by providing a safe shelter for parasite replication. In response to invading pathogens, however, macrophages induce an oxidative burst as a mechanism of defense to promote pathogen removal and contribute to signaling pathways involving inflammation and the immune response. Thus, oxidative stress plays a dual role in infection whereby free radicals protect against invading pathogens but can also cause inflammation resulting in tissue damage. The induced oxidative stress in parasitic infections triggers the activation in the host of the antioxidant response to counteract the damaging oxidative burst. Consequently, macrophages are crucial for disease progression or control. The ultimate outcome depends on dangerous liaisons between the infecting <i>Leishmania</i> spp. and the type and strength of the host immune response. |
| first_indexed | 2024-03-09T04:20:00Z |
| format | Article |
| id | doaj.art-5624272d767a4ca89f7a9dbc18cdfa0e |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-09T04:20:00Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-5624272d767a4ca89f7a9dbc18cdfa0e2023-12-03T13:48:51ZengMDPI AGPathogens2076-08172022-03-0111440910.3390/pathogens11040409The Dangerous Liaisons in the Oxidative Stress Response to <i>Leishmania</i> InfectionMarta Reverte0Tiia Snäkä1Nicolas Fasel2Department of Biochemistry, Faculty of Biology and Medicine, University of Lausanne, 1066 Lausanne, SwitzerlandDepartment of Biochemistry, Faculty of Biology and Medicine, University of Lausanne, 1066 Lausanne, SwitzerlandDepartment of Biochemistry, Faculty of Biology and Medicine, University of Lausanne, 1066 Lausanne, Switzerland<i>Leishmania</i> parasites preferentially invade macrophages, the professional phagocytic cells, at the site of infection. Macrophages play conflicting roles in <i>Leishmania</i> infection either by the destruction of internalized parasites or by providing a safe shelter for parasite replication. In response to invading pathogens, however, macrophages induce an oxidative burst as a mechanism of defense to promote pathogen removal and contribute to signaling pathways involving inflammation and the immune response. Thus, oxidative stress plays a dual role in infection whereby free radicals protect against invading pathogens but can also cause inflammation resulting in tissue damage. The induced oxidative stress in parasitic infections triggers the activation in the host of the antioxidant response to counteract the damaging oxidative burst. Consequently, macrophages are crucial for disease progression or control. The ultimate outcome depends on dangerous liaisons between the infecting <i>Leishmania</i> spp. and the type and strength of the host immune response.https://www.mdpi.com/2076-0817/11/4/409macrophageROSinflammationNRF2NF-kB<i>Leishmania</i> |
| spellingShingle | Marta Reverte Tiia Snäkä Nicolas Fasel The Dangerous Liaisons in the Oxidative Stress Response to <i>Leishmania</i> Infection Pathogens macrophage ROS inflammation NRF2 NF-kB <i>Leishmania</i> |
| title | The Dangerous Liaisons in the Oxidative Stress Response to <i>Leishmania</i> Infection |
| title_full | The Dangerous Liaisons in the Oxidative Stress Response to <i>Leishmania</i> Infection |
| title_fullStr | The Dangerous Liaisons in the Oxidative Stress Response to <i>Leishmania</i> Infection |
| title_full_unstemmed | The Dangerous Liaisons in the Oxidative Stress Response to <i>Leishmania</i> Infection |
| title_short | The Dangerous Liaisons in the Oxidative Stress Response to <i>Leishmania</i> Infection |
| title_sort | dangerous liaisons in the oxidative stress response to i leishmania i infection |
| topic | macrophage ROS inflammation NRF2 NF-kB <i>Leishmania</i> |
| url | https://www.mdpi.com/2076-0817/11/4/409 |
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