Anti-Arthritic and Anti-Cancer Activities of Polyphenols: A Review of the Most Recent In Vitro Assays
Polyphenols have gained widespread attention as they are effective in the prevention and management of various diseases, including cancer diseases (CD) and rheumatoid arthritis (RA). They are natural organic substances present in fruits, vegetables, and spices. Polyphenols interact with various kind...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/2/361 |
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| author | Muhammad Ali Viviana Benfante Alessandro Stefano Anthony Yezzi Domenico Di Raimondo Antonino Tuttolomondo Albert Comelli |
| author_facet | Muhammad Ali Viviana Benfante Alessandro Stefano Anthony Yezzi Domenico Di Raimondo Antonino Tuttolomondo Albert Comelli |
| author_sort | Muhammad Ali |
| collection | DOAJ |
| description | Polyphenols have gained widespread attention as they are effective in the prevention and management of various diseases, including cancer diseases (CD) and rheumatoid arthritis (RA). They are natural organic substances present in fruits, vegetables, and spices. Polyphenols interact with various kinds of receptors and membranes. They modulate different signal cascades and interact with the enzymes responsible for CD and RA. These interactions involve cellular machinery, from cell membranes to major nuclear components, and provide information on their beneficial effects on health. These actions provide evidence for their pharmaceutical exploitation in the treatment of CD and RA. In this review, we discuss different pathways, modulated by polyphenols, which are involved in CD and RA. A search of the most recent relevant publications was carried out with the following criteria: publication date, 2012–2022; language, English; study design, in vitro; and the investigation of polyphenols present in extra virgin olive, grapes, and spices in the context of RA and CD, including, when available, the underlying molecular mechanisms. This review is valuable for clarifying the mechanisms of polyphenols targeting the pathways of senescence and leading to the development of CD and RA treatments. Herein, we focus on research reports that emphasize antioxidant properties. |
| first_indexed | 2024-03-11T08:32:24Z |
| format | Article |
| id | doaj.art-5624b30d2bee4de8b8da949765a91307 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T08:32:24Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-5624b30d2bee4de8b8da949765a913072023-11-16T21:40:11ZengMDPI AGLife2075-17292023-01-0113236110.3390/life13020361Anti-Arthritic and Anti-Cancer Activities of Polyphenols: A Review of the Most Recent In Vitro AssaysMuhammad Ali0Viviana Benfante1Alessandro Stefano2Anthony Yezzi3Domenico Di Raimondo4Antonino Tuttolomondo5Albert Comelli6Ri.MED Foundation, Via Bandiera 11, 90133 Palermo, ItalyRi.MED Foundation, Via Bandiera 11, 90133 Palermo, ItalyInstitute of Molecular Bioimaging and Physiology, National Research Council (IBFM-CNR), 90015 Cefalù, ItalyDepartment of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USADepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Molecular and Clinical Medicine, University of Palermo, 90127 Palermo, ItalyDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Molecular and Clinical Medicine, University of Palermo, 90127 Palermo, ItalyRi.MED Foundation, Via Bandiera 11, 90133 Palermo, ItalyPolyphenols have gained widespread attention as they are effective in the prevention and management of various diseases, including cancer diseases (CD) and rheumatoid arthritis (RA). They are natural organic substances present in fruits, vegetables, and spices. Polyphenols interact with various kinds of receptors and membranes. They modulate different signal cascades and interact with the enzymes responsible for CD and RA. These interactions involve cellular machinery, from cell membranes to major nuclear components, and provide information on their beneficial effects on health. These actions provide evidence for their pharmaceutical exploitation in the treatment of CD and RA. In this review, we discuss different pathways, modulated by polyphenols, which are involved in CD and RA. A search of the most recent relevant publications was carried out with the following criteria: publication date, 2012–2022; language, English; study design, in vitro; and the investigation of polyphenols present in extra virgin olive, grapes, and spices in the context of RA and CD, including, when available, the underlying molecular mechanisms. This review is valuable for clarifying the mechanisms of polyphenols targeting the pathways of senescence and leading to the development of CD and RA treatments. Herein, we focus on research reports that emphasize antioxidant properties.https://www.mdpi.com/2075-1729/13/2/361polyphenolsrheumatoid arthritiscancerin vitrometastasissignaling cascade |
| spellingShingle | Muhammad Ali Viviana Benfante Alessandro Stefano Anthony Yezzi Domenico Di Raimondo Antonino Tuttolomondo Albert Comelli Anti-Arthritic and Anti-Cancer Activities of Polyphenols: A Review of the Most Recent In Vitro Assays Life polyphenols rheumatoid arthritis cancer in vitro metastasis signaling cascade |
| title | Anti-Arthritic and Anti-Cancer Activities of Polyphenols: A Review of the Most Recent In Vitro Assays |
| title_full | Anti-Arthritic and Anti-Cancer Activities of Polyphenols: A Review of the Most Recent In Vitro Assays |
| title_fullStr | Anti-Arthritic and Anti-Cancer Activities of Polyphenols: A Review of the Most Recent In Vitro Assays |
| title_full_unstemmed | Anti-Arthritic and Anti-Cancer Activities of Polyphenols: A Review of the Most Recent In Vitro Assays |
| title_short | Anti-Arthritic and Anti-Cancer Activities of Polyphenols: A Review of the Most Recent In Vitro Assays |
| title_sort | anti arthritic and anti cancer activities of polyphenols a review of the most recent in vitro assays |
| topic | polyphenols rheumatoid arthritis cancer in vitro metastasis signaling cascade |
| url | https://www.mdpi.com/2075-1729/13/2/361 |
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