Multiorgan involvement due to cytomegalovirus infection in AIDS
Cytomegalovirus (CMV) infection is a relatively late complication of AIDS. Like other viruses contributing to co-morbidity of HIV infection, cytomegalovirus has the propensity to cause multiorgan involvement. We report the case of a 34-year-old seropositive man who presented with bilateral lower lim...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
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| Series: | Brazilian Journal of Infectious Diseases |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100039&lng=en&tlng=en |
| _version_ | 1819014511940599808 |
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| author | Shounak Majumder Sanjay K. Mandal Dipanjan Bandyopadhyay Subhasis Roy Chowdhury Partha P. Chakraborty Mitra K. |
| author_facet | Shounak Majumder Sanjay K. Mandal Dipanjan Bandyopadhyay Subhasis Roy Chowdhury Partha P. Chakraborty Mitra K. |
| author_sort | Shounak Majumder |
| collection | DOAJ |
| description | Cytomegalovirus (CMV) infection is a relatively late complication of AIDS. Like other viruses contributing to co-morbidity of HIV infection, cytomegalovirus has the propensity to cause multiorgan involvement. We report the case of a 34-year-old seropositive man who presented with bilateral lower limb weakness and symptomatic pallor. He was already on antiretroviral drugs for a month prior to presentation. Detailed clinical examination and laboratory investigations revealed cytomegalovirus polyradiculoneuropathy associated with bone marrow dysplasia. Dysplasia of haematopoeitic cell lines occurs in 30% to 70% of HIV infected patients, and is often indistinguishable from myelodysplastic syndrome. However, in our case, the bone marrow picture reverted back to normal with treatment of the CMV infection, pointing to a possible role of CMV as the causative agent of bone marrow dysplasia. Moreover, CMV has been incriminated as a pathogen producing the immune reconstitution inflammatory syndrome. The onset of the disease in our case one month after initiation of HAART strongly raises the possibility of this being a case of CMV related IRIS. This is the first reported case where IRIS has presented with CMV polyradiculoneuropathy and bone marrow dysplasia. We would like to highlight that in today's era of HIV care, clinicians should be aware of the possibility of multiorgan involvement by CMV, for appropriate management of this disease in the background of AIDS. |
| first_indexed | 2024-12-21T02:17:01Z |
| format | Article |
| id | doaj.art-5625406b64b54a3299e2e6231ded2073 |
| institution | Directory Open Access Journal |
| issn | 1678-4391 |
| language | English |
| last_indexed | 2024-12-21T02:17:01Z |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-5625406b64b54a3299e2e6231ded20732022-12-21T19:19:15ZengElsevierBrazilian Journal of Infectious Diseases1678-439111117617810.1590/S1413-86702007000100039S1413-86702007000100039Multiorgan involvement due to cytomegalovirus infection in AIDSShounak MajumderSanjay K. MandalDipanjan Bandyopadhyay0Subhasis Roy ChowdhuryPartha P. Chakraborty1Mitra K.Bankura Sammilani Medical CollegeMidnapore Medical CollegeCytomegalovirus (CMV) infection is a relatively late complication of AIDS. Like other viruses contributing to co-morbidity of HIV infection, cytomegalovirus has the propensity to cause multiorgan involvement. We report the case of a 34-year-old seropositive man who presented with bilateral lower limb weakness and symptomatic pallor. He was already on antiretroviral drugs for a month prior to presentation. Detailed clinical examination and laboratory investigations revealed cytomegalovirus polyradiculoneuropathy associated with bone marrow dysplasia. Dysplasia of haematopoeitic cell lines occurs in 30% to 70% of HIV infected patients, and is often indistinguishable from myelodysplastic syndrome. However, in our case, the bone marrow picture reverted back to normal with treatment of the CMV infection, pointing to a possible role of CMV as the causative agent of bone marrow dysplasia. Moreover, CMV has been incriminated as a pathogen producing the immune reconstitution inflammatory syndrome. The onset of the disease in our case one month after initiation of HAART strongly raises the possibility of this being a case of CMV related IRIS. This is the first reported case where IRIS has presented with CMV polyradiculoneuropathy and bone marrow dysplasia. We would like to highlight that in today's era of HIV care, clinicians should be aware of the possibility of multiorgan involvement by CMV, for appropriate management of this disease in the background of AIDS.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100039&lng=en&tlng=enAIDScytomegalovirusmultiorgan involvement |
| spellingShingle | Shounak Majumder Sanjay K. Mandal Dipanjan Bandyopadhyay Subhasis Roy Chowdhury Partha P. Chakraborty Mitra K. Multiorgan involvement due to cytomegalovirus infection in AIDS Brazilian Journal of Infectious Diseases AIDS cytomegalovirus multiorgan involvement |
| title | Multiorgan involvement due to cytomegalovirus infection in AIDS |
| title_full | Multiorgan involvement due to cytomegalovirus infection in AIDS |
| title_fullStr | Multiorgan involvement due to cytomegalovirus infection in AIDS |
| title_full_unstemmed | Multiorgan involvement due to cytomegalovirus infection in AIDS |
| title_short | Multiorgan involvement due to cytomegalovirus infection in AIDS |
| title_sort | multiorgan involvement due to cytomegalovirus infection in aids |
| topic | AIDS cytomegalovirus multiorgan involvement |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100039&lng=en&tlng=en |
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