Pattern Recognition Receptors in Multiple Sclerosis and Its Animal Models
Pattern recognition receptors (PRRs) coordinate the innate immune response and have a significant role in the development of multiple sclerosis (MS). Accumulating evidence has identified both pathogenic and protective functions of PRR signaling in MS and its animal model, experimental autoimmune enc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.02644/full |
| _version_ | 1818202595417653248 |
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| author | M. Elizabeth Deerhake Debolina D. Biswas William E. Barclay Mari L. Shinohara Mari L. Shinohara |
| author_facet | M. Elizabeth Deerhake Debolina D. Biswas William E. Barclay Mari L. Shinohara Mari L. Shinohara |
| author_sort | M. Elizabeth Deerhake |
| collection | DOAJ |
| description | Pattern recognition receptors (PRRs) coordinate the innate immune response and have a significant role in the development of multiple sclerosis (MS). Accumulating evidence has identified both pathogenic and protective functions of PRR signaling in MS and its animal model, experimental autoimmune encephalomyelitis (EAE). Additionally, evidence for PRR signaling in non-immune cells and PRR responses to host-derived endogenous ligands has also revealed new pathways controlling the development of CNS autoimmunity. Many PRRs remain uncharacterized in MS and EAE, and understanding the distinct triggers and functions of PRR signaling in CNS autoimmunity requires further investigation. In this brief review, we discuss the diverse pathogenic and protective functions of PRRs in MS and EAE, and highlight major avenues for future research. |
| first_indexed | 2024-12-12T03:11:57Z |
| format | Article |
| id | doaj.art-562597864f864ccb8d4e580e0d1c1de9 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-12T03:11:57Z |
| publishDate | 2019-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-562597864f864ccb8d4e580e0d1c1de92022-12-22T00:40:23ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-11-011010.3389/fimmu.2019.02644496572Pattern Recognition Receptors in Multiple Sclerosis and Its Animal ModelsM. Elizabeth Deerhake0Debolina D. Biswas1William E. Barclay2Mari L. Shinohara3Mari L. Shinohara4Department of Immunology, Duke University School of Medicine, Durham, NC, United StatesDepartment of Immunology, Duke University School of Medicine, Durham, NC, United StatesDepartment of Immunology, Duke University School of Medicine, Durham, NC, United StatesDepartment of Immunology, Duke University School of Medicine, Durham, NC, United StatesDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, United StatesPattern recognition receptors (PRRs) coordinate the innate immune response and have a significant role in the development of multiple sclerosis (MS). Accumulating evidence has identified both pathogenic and protective functions of PRR signaling in MS and its animal model, experimental autoimmune encephalomyelitis (EAE). Additionally, evidence for PRR signaling in non-immune cells and PRR responses to host-derived endogenous ligands has also revealed new pathways controlling the development of CNS autoimmunity. Many PRRs remain uncharacterized in MS and EAE, and understanding the distinct triggers and functions of PRR signaling in CNS autoimmunity requires further investigation. In this brief review, we discuss the diverse pathogenic and protective functions of PRRs in MS and EAE, and highlight major avenues for future research.https://www.frontiersin.org/article/10.3389/fimmu.2019.02644/fullpattern recognition receptors (PRRs)multiple sclerosis (MS)experimental autoimmune encephalomyelitis (EAE)Toll-like receptors (TLRs)NOD-like receptors (NLRs)C-type lectin receptors (CLRs) |
| spellingShingle | M. Elizabeth Deerhake Debolina D. Biswas William E. Barclay Mari L. Shinohara Mari L. Shinohara Pattern Recognition Receptors in Multiple Sclerosis and Its Animal Models Frontiers in Immunology pattern recognition receptors (PRRs) multiple sclerosis (MS) experimental autoimmune encephalomyelitis (EAE) Toll-like receptors (TLRs) NOD-like receptors (NLRs) C-type lectin receptors (CLRs) |
| title | Pattern Recognition Receptors in Multiple Sclerosis and Its Animal Models |
| title_full | Pattern Recognition Receptors in Multiple Sclerosis and Its Animal Models |
| title_fullStr | Pattern Recognition Receptors in Multiple Sclerosis and Its Animal Models |
| title_full_unstemmed | Pattern Recognition Receptors in Multiple Sclerosis and Its Animal Models |
| title_short | Pattern Recognition Receptors in Multiple Sclerosis and Its Animal Models |
| title_sort | pattern recognition receptors in multiple sclerosis and its animal models |
| topic | pattern recognition receptors (PRRs) multiple sclerosis (MS) experimental autoimmune encephalomyelitis (EAE) Toll-like receptors (TLRs) NOD-like receptors (NLRs) C-type lectin receptors (CLRs) |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.02644/full |
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