The Association between the <i>ALDH2</i> rs671 Polymorphism and Athletic Performance in Japanese Power and Strength Athletes
The rs671 polymorphism is associated with the enzymatic activity of aldehyde dehydrogenase 2 (ALDH2), which is weakened by the A allele in East Asians. We recently reported the association of this polymorphism with the athletic status in athletic cohorts and the muscle strength of non-athletic cohor...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/10/1735 |
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| author | Aoto Saito Mika Saito Kathleen Y. de Almeida Hiroki Homma Minoru Deguchi Ayumu Kozuma Naoyuki Kobatake Takanobu Okamoto Koichi Nakazato Naoki Kikuchi |
| author_facet | Aoto Saito Mika Saito Kathleen Y. de Almeida Hiroki Homma Minoru Deguchi Ayumu Kozuma Naoyuki Kobatake Takanobu Okamoto Koichi Nakazato Naoki Kikuchi |
| author_sort | Aoto Saito |
| collection | DOAJ |
| description | The rs671 polymorphism is associated with the enzymatic activity of aldehyde dehydrogenase 2 (ALDH2), which is weakened by the A allele in East Asians. We recently reported the association of this polymorphism with the athletic status in athletic cohorts and the muscle strength of non-athletic cohorts. Therefore, we hypothesized the association of <i>ALDH2</i> rs671 polymorphism with the performance in power/strength athletes. We aimed to clarify the relationship between the <i>ALDH2</i> rs671 polymorphism and performance in power/strength athletes. Participants comprising 253 power/strength athletes (167 men and 86 women) and 721 healthy controls (303 men and 418 women) were investigated. The power/strength athletes were divided into classic powerlifting (<i>n</i> = 84) and weightlifting (<i>n</i> = 169). No differences in the genotypes and allele frequencies of the <i>ALDH2</i> rs671 polymorphism and an association between performance and the <i>ALDH2</i> rs671 genotype were observed in weightlifters. However, the relative values per body weight of the total record were lower in powerlifters with the GA + AA genotype than those with the GG genotype (7.1 ± 1.2 vs. 7.8 ± 1.0; <i>p</i> = 0.010, partial η<sup>2</sup> = 0.08). Our results collectively indicate a role of the <i>ALDH2</i> rs671 polymorphism in strength performance in powerlifters. |
| first_indexed | 2024-03-09T12:16:45Z |
| format | Article |
| id | doaj.art-56276809582a4030b02f1125a4c87e82 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-09T12:16:45Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-56276809582a4030b02f1125a4c87e822023-11-30T22:45:03ZengMDPI AGGenes2073-44252022-09-011310173510.3390/genes13101735The Association between the <i>ALDH2</i> rs671 Polymorphism and Athletic Performance in Japanese Power and Strength AthletesAoto Saito0Mika Saito1Kathleen Y. de Almeida2Hiroki Homma3Minoru Deguchi4Ayumu Kozuma5Naoyuki Kobatake6Takanobu Okamoto7Koichi Nakazato8Naoki Kikuchi9Graduate School of Health and Sport Science, Nippon Sport Science University, Tokyo 158-8508, JapanGraduate School of Health and Sport Science, Nippon Sport Science University, Tokyo 158-8508, JapanGraduate School of Health and Sport Science, Nippon Sport Science University, Tokyo 158-8508, JapanGraduate School of Health and Sport Science, Nippon Sport Science University, Tokyo 158-8508, JapanGraduate School of Health and Sport Science, Nippon Sport Science University, Tokyo 158-8508, JapanGraduate School of Health and Sport Science, Nippon Sport Science University, Tokyo 158-8508, JapanFaculty of Sport Science, Nippon Sport Science University, Tokyo 158-8508, JapanGraduate School of Health and Sport Science, Nippon Sport Science University, Tokyo 158-8508, JapanGraduate School of Health and Sport Science, Nippon Sport Science University, Tokyo 158-8508, JapanGraduate School of Health and Sport Science, Nippon Sport Science University, Tokyo 158-8508, JapanThe rs671 polymorphism is associated with the enzymatic activity of aldehyde dehydrogenase 2 (ALDH2), which is weakened by the A allele in East Asians. We recently reported the association of this polymorphism with the athletic status in athletic cohorts and the muscle strength of non-athletic cohorts. Therefore, we hypothesized the association of <i>ALDH2</i> rs671 polymorphism with the performance in power/strength athletes. We aimed to clarify the relationship between the <i>ALDH2</i> rs671 polymorphism and performance in power/strength athletes. Participants comprising 253 power/strength athletes (167 men and 86 women) and 721 healthy controls (303 men and 418 women) were investigated. The power/strength athletes were divided into classic powerlifting (<i>n</i> = 84) and weightlifting (<i>n</i> = 169). No differences in the genotypes and allele frequencies of the <i>ALDH2</i> rs671 polymorphism and an association between performance and the <i>ALDH2</i> rs671 genotype were observed in weightlifters. However, the relative values per body weight of the total record were lower in powerlifters with the GA + AA genotype than those with the GG genotype (7.1 ± 1.2 vs. 7.8 ± 1.0; <i>p</i> = 0.010, partial η<sup>2</sup> = 0.08). Our results collectively indicate a role of the <i>ALDH2</i> rs671 polymorphism in strength performance in powerlifters.https://www.mdpi.com/2073-4425/13/10/1735polymorphismgenotypeathletic performancepower/strength athletesmitochondrial aldehyde dehydrogenase 2 |
| spellingShingle | Aoto Saito Mika Saito Kathleen Y. de Almeida Hiroki Homma Minoru Deguchi Ayumu Kozuma Naoyuki Kobatake Takanobu Okamoto Koichi Nakazato Naoki Kikuchi The Association between the <i>ALDH2</i> rs671 Polymorphism and Athletic Performance in Japanese Power and Strength Athletes Genes polymorphism genotype athletic performance power/strength athletes mitochondrial aldehyde dehydrogenase 2 |
| title | The Association between the <i>ALDH2</i> rs671 Polymorphism and Athletic Performance in Japanese Power and Strength Athletes |
| title_full | The Association between the <i>ALDH2</i> rs671 Polymorphism and Athletic Performance in Japanese Power and Strength Athletes |
| title_fullStr | The Association between the <i>ALDH2</i> rs671 Polymorphism and Athletic Performance in Japanese Power and Strength Athletes |
| title_full_unstemmed | The Association between the <i>ALDH2</i> rs671 Polymorphism and Athletic Performance in Japanese Power and Strength Athletes |
| title_short | The Association between the <i>ALDH2</i> rs671 Polymorphism and Athletic Performance in Japanese Power and Strength Athletes |
| title_sort | association between the i aldh2 i rs671 polymorphism and athletic performance in japanese power and strength athletes |
| topic | polymorphism genotype athletic performance power/strength athletes mitochondrial aldehyde dehydrogenase 2 |
| url | https://www.mdpi.com/2073-4425/13/10/1735 |
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