Embryo Transfer Procedural Parameters Do Not Predict IVF Cycle Outcome
Background: this study aims to assess the effect of embryo transfer (ET) performance parameters of a technical nature on IVF outcome. Methods: A total of 1417 ETs from a single IVF center were included in this prospective observational study. The parameters investigated were as follows: the presence...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-02-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/13/5/1312 |
| _version_ | 1797264289683210240 |
|---|---|
| author | Konstantinos Sfakianoudis Evangelos Maziotis Anna Trypidi Sokratis Grigoriadis Terpsithea Vaxevanoglou Irene Angeli Anna Rapani Amalia Kotsifaki Kalliopi Pistola Agni Pantou Konstantinos Dafopoulos Konstantinos Pantos Mara Simopoulou |
| author_facet | Konstantinos Sfakianoudis Evangelos Maziotis Anna Trypidi Sokratis Grigoriadis Terpsithea Vaxevanoglou Irene Angeli Anna Rapani Amalia Kotsifaki Kalliopi Pistola Agni Pantou Konstantinos Dafopoulos Konstantinos Pantos Mara Simopoulou |
| author_sort | Konstantinos Sfakianoudis |
| collection | DOAJ |
| description | Background: this study aims to assess the effect of embryo transfer (ET) performance parameters of a technical nature on IVF outcome. Methods: A total of 1417 ETs from a single IVF center were included in this prospective observational study. The parameters investigated were as follows: the presence of cervical mucus post catheter withdrawal, the presence of blood, catheter reload, the employment of a tenaculum and stylet, catheter resistance as experienced by the physician and patient discomfort. Results: When ET performance parameters were associated with clinical outcomes on a singular level, none of the ET parameters presented with any statistical significance. The evaluation of covariates indicated that the number and the quality of transferred embryos, as well as maternal age, exerted a statistically significant effect on clinical outcomes. In a multivariate analysis, only the presence of mucus along with significant catheter resistance presented with statistical significance; however, when adjusting for covariates, this combination showed no statistically significant effect on clinical outcomes. Conclusions: the results indicate that the time-consuming process of recording and analyzing ET performance parameters fails to offer any additional value in predicting the cycle’s outcome, while factors like embryo quality and number, as well as maternal age, seem to be the sole robust predictive factors of an IVF cycle. |
| first_indexed | 2024-04-25T00:26:32Z |
| format | Article |
| id | doaj.art-5627f7db62a34a819a4923569288d6b5 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-04-25T00:26:32Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-5627f7db62a34a819a4923569288d6b52024-03-12T16:47:58ZengMDPI AGJournal of Clinical Medicine2077-03832024-02-01135131210.3390/jcm13051312Embryo Transfer Procedural Parameters Do Not Predict IVF Cycle OutcomeKonstantinos Sfakianoudis0Evangelos Maziotis1Anna Trypidi2Sokratis Grigoriadis3Terpsithea Vaxevanoglou4Irene Angeli5Anna Rapani6Amalia Kotsifaki7Kalliopi Pistola8Agni Pantou9Konstantinos Dafopoulos10Konstantinos Pantos11Mara Simopoulou12Genesis Athens Clinic, Centre for Human Reproduction, Papanikoli, 15232 Athens, GreeceDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceGenesis Athens Clinic, Centre for Human Reproduction, Papanikoli, 15232 Athens, GreeceGenesis Athens Clinic, Centre for Human Reproduction, Papanikoli, 15232 Athens, GreeceDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceGenesis Athens Clinic, Centre for Human Reproduction, Papanikoli, 15232 Athens, GreeceDepartment of Obstetrics and Gynecology, School of Health Sciences, Faculty of Medicine, University of Thessaly, 41500 Larisa, GreeceGenesis Athens Clinic, Centre for Human Reproduction, Papanikoli, 15232 Athens, GreeceDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceBackground: this study aims to assess the effect of embryo transfer (ET) performance parameters of a technical nature on IVF outcome. Methods: A total of 1417 ETs from a single IVF center were included in this prospective observational study. The parameters investigated were as follows: the presence of cervical mucus post catheter withdrawal, the presence of blood, catheter reload, the employment of a tenaculum and stylet, catheter resistance as experienced by the physician and patient discomfort. Results: When ET performance parameters were associated with clinical outcomes on a singular level, none of the ET parameters presented with any statistical significance. The evaluation of covariates indicated that the number and the quality of transferred embryos, as well as maternal age, exerted a statistically significant effect on clinical outcomes. In a multivariate analysis, only the presence of mucus along with significant catheter resistance presented with statistical significance; however, when adjusting for covariates, this combination showed no statistically significant effect on clinical outcomes. Conclusions: the results indicate that the time-consuming process of recording and analyzing ET performance parameters fails to offer any additional value in predicting the cycle’s outcome, while factors like embryo quality and number, as well as maternal age, seem to be the sole robust predictive factors of an IVF cycle.https://www.mdpi.com/2077-0383/13/5/1312assisted reproductionIVFembryo transferoutcomepre-implantation embryo |
| spellingShingle | Konstantinos Sfakianoudis Evangelos Maziotis Anna Trypidi Sokratis Grigoriadis Terpsithea Vaxevanoglou Irene Angeli Anna Rapani Amalia Kotsifaki Kalliopi Pistola Agni Pantou Konstantinos Dafopoulos Konstantinos Pantos Mara Simopoulou Embryo Transfer Procedural Parameters Do Not Predict IVF Cycle Outcome Journal of Clinical Medicine assisted reproduction IVF embryo transfer outcome pre-implantation embryo |
| title | Embryo Transfer Procedural Parameters Do Not Predict IVF Cycle Outcome |
| title_full | Embryo Transfer Procedural Parameters Do Not Predict IVF Cycle Outcome |
| title_fullStr | Embryo Transfer Procedural Parameters Do Not Predict IVF Cycle Outcome |
| title_full_unstemmed | Embryo Transfer Procedural Parameters Do Not Predict IVF Cycle Outcome |
| title_short | Embryo Transfer Procedural Parameters Do Not Predict IVF Cycle Outcome |
| title_sort | embryo transfer procedural parameters do not predict ivf cycle outcome |
| topic | assisted reproduction IVF embryo transfer outcome pre-implantation embryo |
| url | https://www.mdpi.com/2077-0383/13/5/1312 |
| work_keys_str_mv | AT konstantinossfakianoudis embryotransferproceduralparametersdonotpredictivfcycleoutcome AT evangelosmaziotis embryotransferproceduralparametersdonotpredictivfcycleoutcome AT annatrypidi embryotransferproceduralparametersdonotpredictivfcycleoutcome AT sokratisgrigoriadis embryotransferproceduralparametersdonotpredictivfcycleoutcome AT terpsitheavaxevanoglou embryotransferproceduralparametersdonotpredictivfcycleoutcome AT ireneangeli embryotransferproceduralparametersdonotpredictivfcycleoutcome AT annarapani embryotransferproceduralparametersdonotpredictivfcycleoutcome AT amaliakotsifaki embryotransferproceduralparametersdonotpredictivfcycleoutcome AT kalliopipistola embryotransferproceduralparametersdonotpredictivfcycleoutcome AT agnipantou embryotransferproceduralparametersdonotpredictivfcycleoutcome AT konstantinosdafopoulos embryotransferproceduralparametersdonotpredictivfcycleoutcome AT konstantinospantos embryotransferproceduralparametersdonotpredictivfcycleoutcome AT marasimopoulou embryotransferproceduralparametersdonotpredictivfcycleoutcome |