Store-operated calcium entry via ORAI1 regulates doxorubicin-induced apoptosis and prevents cardiotoxicity in cardiac fibroblasts.

Store-operated calcium entry via ORAI1 regulates doxorubicin-induced apoptosis and prevents cardiotoxicity in cardiac fibroblasts.

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Despite exhibiting cardiotoxicity, doxorubicin (DOX) is widely used for cancer treatments. Cardiac fibroblasts (CFs) are important in the pathogenesis of heart failure. This necessitates the study of the effect of DOX on CFs. The impairment of calcium (Ca2+) homeostasis is a common mechanism of hear...

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Bibliographic Details
Main Authors: Hiroko Nemoto, Masanari Umemura, Fumina Suzuki, Akane Nagasako, Kagemichi Nagao, Yuko Hidaka, Rina Nakakaji, Keiji Uchida, Shinichi Suzuki, Munetaka Masuda, Yoshihiro Ishikawa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0278613

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