DNA Interaction with Coordination Compounds of Cd(II)containing 1,10-Phenanthroline
The experimental study of the DNA interaction with three cadmium coordination compounds [Cd(phen)<sub>3</sub>](CH<sub>3</sub>CO<sub>2</sub>)<sub>2</sub>, [Cd(phen)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>](CH<sub&g...
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MDPI AG
2024-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/3/1820 |
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| author | Nina Kasyanenko Eugeny Belyi Irina Silanteva Victor Demidov Andrei Komolkin |
| author_facet | Nina Kasyanenko Eugeny Belyi Irina Silanteva Victor Demidov Andrei Komolkin |
| author_sort | Nina Kasyanenko |
| collection | DOAJ |
| description | The experimental study of the DNA interaction with three cadmium coordination compounds [Cd(phen)<sub>3</sub>](CH<sub>3</sub>CO<sub>2</sub>)<sub>2</sub>, [Cd(phen)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>](CH<sub>3</sub>CO<sub>2</sub>)<sub>2</sub>, and [Cd<sub>2</sub>(phen)<sub>4</sub>(H<sub>2</sub>O)<sub>2</sub>](CH<sub>3</sub>CO<sub>2</sub>)<sub>4</sub> was carried out using spectrophotometry, viscosity, and dynamic light scattering methods. The role of the solution ionic strength (concentration of NaCl) was analyzed. All compounds can penetrate (fully or partly) to the major or minor DNA grooves. It was shown that, in addition to the important role of electrostatic interactions in the formation of the complex, intercalation of the 1,10-phenanthroline ligand occurs for compounds [Cd(phen)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>](CH<sub>3</sub>CO<sub>2</sub>)<sub>2</sub> and [Cd<sub>2</sub>(phen)<sub>4</sub>(H<sub>2</sub>O)<sub>2</sub>](CH<sub>3</sub>CO<sub>2</sub>)<sub>4</sub>. Compound [Cd(phen)<sub>3</sub>](CH<sub>3</sub>CO<sub>2</sub>)<sub>2</sub> binds to DNA externally. The coordination bond between cadmium and DNA was formed in DNA complexes with [Cd<sub>2</sub>(phen)<sub>4</sub>(H<sub>2</sub>O)<sub>2</sub>](CH<sub>3</sub>CO<sub>2</sub>)<sub>4</sub>. Preliminary computer modeling of the DNA interaction with the compounds used was performed. |
| first_indexed | 2024-03-08T03:54:36Z |
| format | Article |
| id | doaj.art-562ad1eb32c1485fa01657beb1a30ac8 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T03:54:36Z |
| publishDate | 2024-02-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-562ad1eb32c1485fa01657beb1a30ac82024-02-09T15:14:44ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-02-01253182010.3390/ijms25031820DNA Interaction with Coordination Compounds of Cd(II)containing 1,10-PhenanthrolineNina Kasyanenko0Eugeny Belyi1Irina Silanteva2Victor Demidov3Andrei Komolkin4Faculty of Physics, Saint Petersburg State University, 199034 Saint Petersburg, RussiaFaculty of Physics, Saint Petersburg State University, 199034 Saint Petersburg, RussiaFaculty of Physics, Saint Petersburg State University, 199034 Saint Petersburg, RussiaI.V. Grebenshchikov Institute of Silicate Chemistry, Russian Academy of Sciences, 194021 Saint Petersburg, RussiaFaculty of Physics, Saint Petersburg State University, 199034 Saint Petersburg, RussiaThe experimental study of the DNA interaction with three cadmium coordination compounds [Cd(phen)<sub>3</sub>](CH<sub>3</sub>CO<sub>2</sub>)<sub>2</sub>, [Cd(phen)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>](CH<sub>3</sub>CO<sub>2</sub>)<sub>2</sub>, and [Cd<sub>2</sub>(phen)<sub>4</sub>(H<sub>2</sub>O)<sub>2</sub>](CH<sub>3</sub>CO<sub>2</sub>)<sub>4</sub> was carried out using spectrophotometry, viscosity, and dynamic light scattering methods. The role of the solution ionic strength (concentration of NaCl) was analyzed. All compounds can penetrate (fully or partly) to the major or minor DNA grooves. It was shown that, in addition to the important role of electrostatic interactions in the formation of the complex, intercalation of the 1,10-phenanthroline ligand occurs for compounds [Cd(phen)<sub>2</sub>(H<sub>2</sub>O)<sub>2</sub>](CH<sub>3</sub>CO<sub>2</sub>)<sub>2</sub> and [Cd<sub>2</sub>(phen)<sub>4</sub>(H<sub>2</sub>O)<sub>2</sub>](CH<sub>3</sub>CO<sub>2</sub>)<sub>4</sub>. Compound [Cd(phen)<sub>3</sub>](CH<sub>3</sub>CO<sub>2</sub>)<sub>2</sub> binds to DNA externally. The coordination bond between cadmium and DNA was formed in DNA complexes with [Cd<sub>2</sub>(phen)<sub>4</sub>(H<sub>2</sub>O)<sub>2</sub>](CH<sub>3</sub>CO<sub>2</sub>)<sub>4</sub>. Preliminary computer modeling of the DNA interaction with the compounds used was performed.https://www.mdpi.com/1422-0067/25/3/1820Cd(II) compounds1,10-phenanthroline ligandsDNA bindingintercalationmolecular dynamics |
| spellingShingle | Nina Kasyanenko Eugeny Belyi Irina Silanteva Victor Demidov Andrei Komolkin DNA Interaction with Coordination Compounds of Cd(II)containing 1,10-Phenanthroline International Journal of Molecular Sciences Cd(II) compounds 1,10-phenanthroline ligands DNA binding intercalation molecular dynamics |
| title | DNA Interaction with Coordination Compounds of Cd(II)containing 1,10-Phenanthroline |
| title_full | DNA Interaction with Coordination Compounds of Cd(II)containing 1,10-Phenanthroline |
| title_fullStr | DNA Interaction with Coordination Compounds of Cd(II)containing 1,10-Phenanthroline |
| title_full_unstemmed | DNA Interaction with Coordination Compounds of Cd(II)containing 1,10-Phenanthroline |
| title_short | DNA Interaction with Coordination Compounds of Cd(II)containing 1,10-Phenanthroline |
| title_sort | dna interaction with coordination compounds of cd ii containing 1 10 phenanthroline |
| topic | Cd(II) compounds 1,10-phenanthroline ligands DNA binding intercalation molecular dynamics |
| url | https://www.mdpi.com/1422-0067/25/3/1820 |
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