Influence of Lymphatic, Microvascular and Perineural Invasion on Oncological Outcome in Patients with Neuroendocrine Tumors of the Small Intestine
For the histopathological work-up of resected neuroendocrine tumors of the small intestine (siNET), the determination of lymphatic (LI), microvascular (VI) and perineural (PnI) invasion is recommended. Their association with poorer prognosis has already been demonstrated in many tumor entities. Howe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/16/2/305 |
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| author | Frederike Butz Agata Dukaczewska Catarina Alisa Kunze Janina Maren Krömer Lisa Reinhard Henning Jann Uli Fehrenbach Charlotte Friederieke Müller-Debus Tatiana Skachko Johann Pratschke Peter E. Goretzki Martina T. Mogl Eva Maria Dobrindt |
| author_facet | Frederike Butz Agata Dukaczewska Catarina Alisa Kunze Janina Maren Krömer Lisa Reinhard Henning Jann Uli Fehrenbach Charlotte Friederieke Müller-Debus Tatiana Skachko Johann Pratschke Peter E. Goretzki Martina T. Mogl Eva Maria Dobrindt |
| author_sort | Frederike Butz |
| collection | DOAJ |
| description | For the histopathological work-up of resected neuroendocrine tumors of the small intestine (siNET), the determination of lymphatic (LI), microvascular (VI) and perineural (PnI) invasion is recommended. Their association with poorer prognosis has already been demonstrated in many tumor entities. However, the influence of LI, VI and PnI in siNET has not been sufficiently described yet. A retrospective analysis of all patients treated for siNET at the ENETS Center of Excellence Charité–Universitätsmedizin Berlin, from 2010 to 2020 was performed (<i>n</i> = 510). Patients who did not undergo primary resection or had G3 tumors were excluded. In the entire cohort (<i>n</i> = 161), patients with LI, VI and PnI status had more distant metastases (48.0% vs. 71.4%, <i>p</i> = 0.005; 47.1% vs. 84.4%, <i>p</i> < 0.001; 34.2% vs. 84.7%, <i>p</i> < 0.001) and had lower rates of curative surgery (58.0% vs. 21.0%, <i>p</i> < 0.001; 48.3% vs. 16.7%, <i>p</i> < 0.001; 68.4% vs. 14.3%, <i>p</i> < 0.001). Progression-free survival was significantly reduced in patients with LI, VI or PnI compared to patients without. This was also demonstrated in patients who underwent curative surgery. Lymphatic, vascular and perineural invasion were associated with disease progression and recurrence in patients with siNET, and these should therefore be included in postoperative treatment considerations. |
| first_indexed | 2024-03-08T11:03:13Z |
| format | Article |
| id | doaj.art-562be394dcc4495daad82c31f031e1ce |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-08T11:03:13Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-562be394dcc4495daad82c31f031e1ce2024-01-26T15:35:26ZengMDPI AGCancers2072-66942024-01-0116230510.3390/cancers16020305Influence of Lymphatic, Microvascular and Perineural Invasion on Oncological Outcome in Patients with Neuroendocrine Tumors of the Small IntestineFrederike Butz0Agata Dukaczewska1Catarina Alisa Kunze2Janina Maren Krömer3Lisa Reinhard4Henning Jann5Uli Fehrenbach6Charlotte Friederieke Müller-Debus7Tatiana Skachko8Johann Pratschke9Peter E. Goretzki10Martina T. Mogl11Eva Maria Dobrindt12Department of Surgery, Campus Charité Mitte|Campus Virchow-Klinikum, Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, GermanyDepartment of Surgery, Campus Charité Mitte|Campus Virchow-Klinikum, Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, GermanyDepartment of Pathology, Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, GermanyDepartment of Surgery, Campus Charité Mitte|Campus Virchow-Klinikum, Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, GermanyDepartment of Surgery, Campus Charité Mitte|Campus Virchow-Klinikum, Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, GermanyDepartment of Hepatology and Gastroenterology, Campus Charité Mitte|Campus Virchow-Klinikum, Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, GermanyDepartment of Radiology, Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, GermanyDepartment of Surgery, Campus Charité Mitte|Campus Virchow-Klinikum, Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, GermanyDepartment of Surgery, Campus Charité Mitte|Campus Virchow-Klinikum, Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, GermanyDepartment of Surgery, Campus Charité Mitte|Campus Virchow-Klinikum, Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, GermanyDepartment of Surgery, Campus Charité Mitte|Campus Virchow-Klinikum, Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, GermanyDepartment of Surgery, Campus Charité Mitte|Campus Virchow-Klinikum, Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, GermanyDepartment of Surgery, Campus Charité Mitte|Campus Virchow-Klinikum, Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, GermanyFor the histopathological work-up of resected neuroendocrine tumors of the small intestine (siNET), the determination of lymphatic (LI), microvascular (VI) and perineural (PnI) invasion is recommended. Their association with poorer prognosis has already been demonstrated in many tumor entities. However, the influence of LI, VI and PnI in siNET has not been sufficiently described yet. A retrospective analysis of all patients treated for siNET at the ENETS Center of Excellence Charité–Universitätsmedizin Berlin, from 2010 to 2020 was performed (<i>n</i> = 510). Patients who did not undergo primary resection or had G3 tumors were excluded. In the entire cohort (<i>n</i> = 161), patients with LI, VI and PnI status had more distant metastases (48.0% vs. 71.4%, <i>p</i> = 0.005; 47.1% vs. 84.4%, <i>p</i> < 0.001; 34.2% vs. 84.7%, <i>p</i> < 0.001) and had lower rates of curative surgery (58.0% vs. 21.0%, <i>p</i> < 0.001; 48.3% vs. 16.7%, <i>p</i> < 0.001; 68.4% vs. 14.3%, <i>p</i> < 0.001). Progression-free survival was significantly reduced in patients with LI, VI or PnI compared to patients without. This was also demonstrated in patients who underwent curative surgery. Lymphatic, vascular and perineural invasion were associated with disease progression and recurrence in patients with siNET, and these should therefore be included in postoperative treatment considerations.https://www.mdpi.com/2072-6694/16/2/305small-intestinal neuroendocrine tumorsmicrovascular invasionlymphatic invasionperineural invasiononcological outcome |
| spellingShingle | Frederike Butz Agata Dukaczewska Catarina Alisa Kunze Janina Maren Krömer Lisa Reinhard Henning Jann Uli Fehrenbach Charlotte Friederieke Müller-Debus Tatiana Skachko Johann Pratschke Peter E. Goretzki Martina T. Mogl Eva Maria Dobrindt Influence of Lymphatic, Microvascular and Perineural Invasion on Oncological Outcome in Patients with Neuroendocrine Tumors of the Small Intestine Cancers small-intestinal neuroendocrine tumors microvascular invasion lymphatic invasion perineural invasion oncological outcome |
| title | Influence of Lymphatic, Microvascular and Perineural Invasion on Oncological Outcome in Patients with Neuroendocrine Tumors of the Small Intestine |
| title_full | Influence of Lymphatic, Microvascular and Perineural Invasion on Oncological Outcome in Patients with Neuroendocrine Tumors of the Small Intestine |
| title_fullStr | Influence of Lymphatic, Microvascular and Perineural Invasion on Oncological Outcome in Patients with Neuroendocrine Tumors of the Small Intestine |
| title_full_unstemmed | Influence of Lymphatic, Microvascular and Perineural Invasion on Oncological Outcome in Patients with Neuroendocrine Tumors of the Small Intestine |
| title_short | Influence of Lymphatic, Microvascular and Perineural Invasion on Oncological Outcome in Patients with Neuroendocrine Tumors of the Small Intestine |
| title_sort | influence of lymphatic microvascular and perineural invasion on oncological outcome in patients with neuroendocrine tumors of the small intestine |
| topic | small-intestinal neuroendocrine tumors microvascular invasion lymphatic invasion perineural invasion oncological outcome |
| url | https://www.mdpi.com/2072-6694/16/2/305 |
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