Changes in TRPV1-Mediated Physiological Function in Rats Systemically Treated With Capsaicin on the Neonate
Capsaicin is the active component of chili peppers and is a hydrophobic, colorless, odorless, and crystalline to waxy compound. The transient receptor potential vanilloid 1 (TRPV1) is the capsaicin receptor channels that are involved in a variety of functions like transduction and transmission of th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/9/3143 |
| _version_ | 1797569262459551744 |
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| author | Keun-Yeong Jeong |
| author_facet | Keun-Yeong Jeong |
| author_sort | Keun-Yeong Jeong |
| collection | DOAJ |
| description | Capsaicin is the active component of chili peppers and is a hydrophobic, colorless, odorless, and crystalline to waxy compound. The transient receptor potential vanilloid 1 (TRPV1) is the capsaicin receptor channels that are involved in a variety of functions like transduction and transmission of the physiological stimulus. Subcutaneous injection of capsaicin to a newborn rat leads to involuntary lifelong TRPV1 desensitization. Various physiological changes including sensory and homeostatic actions in the body associated with neonatal capsaicin treatment are induced by direct TRPV1 channel targeting. Interesting changes include unique phenomena such as the reduction in pain perception, abnormal body temperature, increase in infection, infectious or neuropathological itching, and irregular circadian core body temperature rhythm. These symptoms are associated with relatively higher fever or loss of sensory c-fiber related to TRPV1 desensitization. The aforementioned outcomes not only provide a warning about the risk of capsaicin exposure in newborns but also indicate the possible occurrence of relatively rare diseases that are difficult to diagnose. Therefore, Therefore, the present review aims to summarize the unique phenomena caused by systemic capsaicin administration in neonatal rats. |
| first_indexed | 2024-03-10T20:09:25Z |
| format | Article |
| id | doaj.art-562d4903fab64798adee092033854bb2 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T20:09:25Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-562d4903fab64798adee092033854bb22023-11-19T23:02:46ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-04-01219314310.3390/ijms21093143Changes in TRPV1-Mediated Physiological Function in Rats Systemically Treated With Capsaicin on the NeonateKeun-Yeong Jeong0MetiMedi Pharmaceuticals Co., Research Center, Incheon 22006, KoreaCapsaicin is the active component of chili peppers and is a hydrophobic, colorless, odorless, and crystalline to waxy compound. The transient receptor potential vanilloid 1 (TRPV1) is the capsaicin receptor channels that are involved in a variety of functions like transduction and transmission of the physiological stimulus. Subcutaneous injection of capsaicin to a newborn rat leads to involuntary lifelong TRPV1 desensitization. Various physiological changes including sensory and homeostatic actions in the body associated with neonatal capsaicin treatment are induced by direct TRPV1 channel targeting. Interesting changes include unique phenomena such as the reduction in pain perception, abnormal body temperature, increase in infection, infectious or neuropathological itching, and irregular circadian core body temperature rhythm. These symptoms are associated with relatively higher fever or loss of sensory c-fiber related to TRPV1 desensitization. The aforementioned outcomes not only provide a warning about the risk of capsaicin exposure in newborns but also indicate the possible occurrence of relatively rare diseases that are difficult to diagnose. Therefore, Therefore, the present review aims to summarize the unique phenomena caused by systemic capsaicin administration in neonatal rats.https://www.mdpi.com/1422-0067/21/9/3143neonatal capsaicin treatmentratTRPV1painhyperthermiainfection |
| spellingShingle | Keun-Yeong Jeong Changes in TRPV1-Mediated Physiological Function in Rats Systemically Treated With Capsaicin on the Neonate International Journal of Molecular Sciences neonatal capsaicin treatment rat TRPV1 pain hyperthermia infection |
| title | Changes in TRPV1-Mediated Physiological Function in Rats Systemically Treated With Capsaicin on the Neonate |
| title_full | Changes in TRPV1-Mediated Physiological Function in Rats Systemically Treated With Capsaicin on the Neonate |
| title_fullStr | Changes in TRPV1-Mediated Physiological Function in Rats Systemically Treated With Capsaicin on the Neonate |
| title_full_unstemmed | Changes in TRPV1-Mediated Physiological Function in Rats Systemically Treated With Capsaicin on the Neonate |
| title_short | Changes in TRPV1-Mediated Physiological Function in Rats Systemically Treated With Capsaicin on the Neonate |
| title_sort | changes in trpv1 mediated physiological function in rats systemically treated with capsaicin on the neonate |
| topic | neonatal capsaicin treatment rat TRPV1 pain hyperthermia infection |
| url | https://www.mdpi.com/1422-0067/21/9/3143 |
| work_keys_str_mv | AT keunyeongjeong changesintrpv1mediatedphysiologicalfunctioninratssystemicallytreatedwithcapsaicinontheneonate |