Pyruvate kinase M1 regulates butyrate metabolism in cancerous colonocytes

Pyruvate kinase M1 regulates butyrate metabolism in cancerous colonocytes

Abstract Colorectal cancer (CRC) cells shift metabolism toward aerobic glycolysis and away from using oxidative substrates such as butyrate. Pyruvate kinase M1/2 (PKM) is an enzyme that catalyzes the last step in glycolysis, which converts phosphoenolpyruvate to pyruvate. M1 and M2 are alternatively...

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Bibliographic Details
Main Authors: Bohye Park, Ji Yeon Kim, Olivia F. Riffey, Presley Dowker-Key, Antje Bruckbauer, James McLoughlin, Ahmed Bettaieb, Dallas R. Donohoe
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-12827-9

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