Determinação espectrofotométrica simultânea de paracetamol e ibuprofeno em formulações farmacêuticas usando calibração multivariada Simultaneous spectrophotometric determination of paracetamol and ibuprofen in pharmaceutical formulations by multivariate calibration
<abstract language="eng">A simple method was proposed for determination of paracetamol and ibuprofen in tablets, based on UV measurements and partial least squares. The procedure was performed at pH 10.5, in the concentration ranges 3.00-15.00 µg ml-1 (paracetamol) and 2.40-12.00 µg...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2007-02-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000100017 |
| _version_ | 1818108791919476736 |
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| author | Marcelo M. Sena Camilla B. Freitas Lucas C. Silva Caridad Noda Pérez Ydilla O. de Paula |
| author_facet | Marcelo M. Sena Camilla B. Freitas Lucas C. Silva Caridad Noda Pérez Ydilla O. de Paula |
| author_sort | Marcelo M. Sena |
| collection | DOAJ |
| description | <abstract language="eng">A simple method was proposed for determination of paracetamol and ibuprofen in tablets, based on UV measurements and partial least squares. The procedure was performed at pH 10.5, in the concentration ranges 3.00-15.00 µg ml-1 (paracetamol) and 2.40-12.00 µg ml-1 (ibuprofen). The model was able to predict paracetamol and ibuprofen in synthetic mixtures with root mean squares errors of prediction of 0.12 and 0.17 µg ml-1, respectively. Figures of merit (sensitivity, limit of detection and precision) were also estimated. The results achieved for the determination of these drugs in pharmaceutical formulations were in agreement with label claims and verified by HPLC. |
| first_indexed | 2024-12-11T02:20:59Z |
| format | Article |
| id | doaj.art-562de47d135041fe9e983d78edd5d5a1 |
| institution | Directory Open Access Journal |
| issn | 0100-4042 1678-7064 |
| language | English |
| last_indexed | 2024-12-11T02:20:59Z |
| publishDate | 2007-02-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-562de47d135041fe9e983d78edd5d5a12022-12-22T01:24:04ZengSociedade Brasileira de QuímicaQuímica Nova0100-40421678-70642007-02-01301757910.1590/S0100-40422007000100017Determinação espectrofotométrica simultânea de paracetamol e ibuprofeno em formulações farmacêuticas usando calibração multivariada Simultaneous spectrophotometric determination of paracetamol and ibuprofen in pharmaceutical formulations by multivariate calibrationMarcelo M. SenaCamilla B. FreitasLucas C. SilvaCaridad Noda PérezYdilla O. de Paula<abstract language="eng">A simple method was proposed for determination of paracetamol and ibuprofen in tablets, based on UV measurements and partial least squares. The procedure was performed at pH 10.5, in the concentration ranges 3.00-15.00 µg ml-1 (paracetamol) and 2.40-12.00 µg ml-1 (ibuprofen). The model was able to predict paracetamol and ibuprofen in synthetic mixtures with root mean squares errors of prediction of 0.12 and 0.17 µg ml-1, respectively. Figures of merit (sensitivity, limit of detection and precision) were also estimated. The results achieved for the determination of these drugs in pharmaceutical formulations were in agreement with label claims and verified by HPLC.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000100017PLSquality controlacetaminophen |
| spellingShingle | Marcelo M. Sena Camilla B. Freitas Lucas C. Silva Caridad Noda Pérez Ydilla O. de Paula Determinação espectrofotométrica simultânea de paracetamol e ibuprofeno em formulações farmacêuticas usando calibração multivariada Simultaneous spectrophotometric determination of paracetamol and ibuprofen in pharmaceutical formulations by multivariate calibration Química Nova PLS quality control acetaminophen |
| title | Determinação espectrofotométrica simultânea de paracetamol e ibuprofeno em formulações farmacêuticas usando calibração multivariada Simultaneous spectrophotometric determination of paracetamol and ibuprofen in pharmaceutical formulations by multivariate calibration |
| title_full | Determinação espectrofotométrica simultânea de paracetamol e ibuprofeno em formulações farmacêuticas usando calibração multivariada Simultaneous spectrophotometric determination of paracetamol and ibuprofen in pharmaceutical formulations by multivariate calibration |
| title_fullStr | Determinação espectrofotométrica simultânea de paracetamol e ibuprofeno em formulações farmacêuticas usando calibração multivariada Simultaneous spectrophotometric determination of paracetamol and ibuprofen in pharmaceutical formulations by multivariate calibration |
| title_full_unstemmed | Determinação espectrofotométrica simultânea de paracetamol e ibuprofeno em formulações farmacêuticas usando calibração multivariada Simultaneous spectrophotometric determination of paracetamol and ibuprofen in pharmaceutical formulations by multivariate calibration |
| title_short | Determinação espectrofotométrica simultânea de paracetamol e ibuprofeno em formulações farmacêuticas usando calibração multivariada Simultaneous spectrophotometric determination of paracetamol and ibuprofen in pharmaceutical formulations by multivariate calibration |
| title_sort | determinacao espectrofotometrica simultanea de paracetamol e ibuprofeno em formulacoes farmaceuticas usando calibracao multivariada simultaneous spectrophotometric determination of paracetamol and ibuprofen in pharmaceutical formulations by multivariate calibration |
| topic | PLS quality control acetaminophen |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000100017 |
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