MicroRNA-34a and MicroRNA-181a Mediate Visfatin-Induced Apoptosis and Oxidative Stress via NF-κB Pathway in Human Osteoarthritic Chondrocytes

MicroRNA-34a and MicroRNA-181a Mediate Visfatin-Induced Apoptosis and Oxidative Stress via NF-κB Pathway in Human Osteoarthritic Chondrocytes

Current evidence suggests a complex interaction between adipokines and microRNA (miRNA) in osteoarthritis (OA) pathogenesis. The present study explored the role of miR-34a and miR-181a in regulating apoptosis and oxidative stress induced by visfatin in human OA chondrocytes. Chondrocytes were transf...

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Bibliographic Details
Main Authors: Sara Cheleschi, Sara Tenti, Nicola Mondanelli, Claudio Corallo, Marcella Barbarino, Stefano Giannotti, Ines Gallo, Antonio Giordano, Antonella Fioravanti
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cells
Subjects:
visfatin
microRNA
osteoarthritis
apoptosis
oxidative stress
chondrocytes
miR-34a
miR-181a
NF-κB
Online Access:https://www.mdpi.com/2073-4409/8/8/874

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