Whole Genome Sequencing Identifies Novel Mutations Associated With Bedaquiline Resistance in Mycobacterium tuberculosis

Whole Genome Sequencing Identifies Novel Mutations Associated With Bedaquiline Resistance in Mycobacterium tuberculosis

Bedaquiline (BDQ), a new antitubercular agent, has been used to treat drug-resistant tuberculosis (TB). Although mutations in atpE, rv0678, and pepQ confer major resistance to BDQ, the mechanisms of resistance to BDQ in vitro and in clinical settings have not been fully elucidated. We selected BDQ-r...

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Bibliographic Details
Main Authors: Qinglong Guo, Jing Bi, Qiao Lin, Taosheng Ye, Zhongyuan Wang, Zhaoqin Wang, Lei Liu, Guoliang Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Mycobacterium tuberculosis
bedaquiline
drug resistance
rv0678
glpK
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.807095/full

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