Expression of Inducible Nitric Oxide Synthase in Keratocystic Odontogenic Tumour and Variants of Ameloblastoma – A Comparative Study
Introduction: The odontogenic keratocyst (OKC) is a histopathologiocally and behaviourally unique and specific entity. It is the most aggressive and recurrent of all the cysts and shows characteristics resembling both cyst and a tumour. The unique nature of OKC and the recent shift of OKC as a...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2014-11-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/5201/10288_CE(Ra)_F(Sh)_PF1(AJ_Sh)_PFA(Sh)_PF2(PAG).pdf |
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| author | Diana.H Maya.R Sekar.B Murali.S Ramesh. K |
| author_facet | Diana.H Maya.R Sekar.B Murali.S Ramesh. K |
| author_sort | Diana.H |
| collection | DOAJ |
| description | Introduction: The odontogenic keratocyst (OKC) is a
histopathologiocally and behaviourally unique and specific
entity. It is the most aggressive and recurrent of all the cysts
and shows characteristics resembling both cyst and a tumour.
The unique nature of OKC and the recent shift of OKC as a
tumour made us evaluate yet another factor, Inducible nitric
oxide synthase an (iNos) enzyme which has been implicated in
the tumourigenesis of various neoplasms.
Aims and Objects: The objective of the study was to analyse
and compare the immunohistochemical expression of iNOS in
odontogenic keratocysts (OKC’s) in variants of ameloblastoma
affecting the oral cavity, to determine the neoplastic potential of
OKC and to reinforce the classification of OKC as keratocystic
odontogenic tumour.
Materials and Methods: Thirty two specimens, eight
specimens each in OKC, follicular ameloblastoma, plexiform
ameloblastoma and unicystic ameloblastoma, taken from the
Oral Pathology Department were randomly selected for this
study and were evaluated for epithelial expression of iNOS by
immunohistochemistry.
Results: Epithelial immunoreactivity to iNOS was strongly
positive in 93.5% of follicular ameloblastomas, 68.7% of
plexiform ameloblastomas, 66.9% of odontogenic keratocysts
and 66.2% of unicystic ameloblastomas.
Conclusion: iNOS may be an important marker involved in
the biological behaviour of OKC. Furthermore the presence
of increased expression of iNOS in Follicular ameloblastomas
followed by Plexiform ameloblastomas, OKCs and Unicystic
ameloblastomas is yet another evidence to support that OKC
could be considered as a neoplasm. |
| first_indexed | 2024-12-11T12:40:21Z |
| format | Article |
| id | doaj.art-562f2865dc3a442da1cfb16bfbcf6db8 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-11T12:40:21Z |
| publishDate | 2014-11-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-562f2865dc3a442da1cfb16bfbcf6db82022-12-22T01:06:59ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2014-11-01811ZC115ZC11810.7860/JCDR/2014/10288.5201Expression of Inducible Nitric Oxide Synthase in Keratocystic Odontogenic Tumour and Variants of Ameloblastoma – A Comparative StudyDiana.H0Maya.R1Sekar.B2Murali.S3Ramesh. K4Consultant Oral Pathologist, Coimbatore, Tamil Nadu, India.Reader, Department of Oral Pathology,Vinayaka Missions Sankarachariyar Dental College, Salem, Tamil Nadu, India.Professor, Department of Oral Pathology,Vinayaka Missions Sankarachariyar Dental College, Salem, Tamil Nadu, India.Professor and Head of Department, Department of Oral Pathology, Vinayaka Missions Sankarachariyar Dental College, Salem, Tamil Nadu, India.Professor, Department of Pedodontics, Vinayaka Missions Sankarachariyar Dental College, Salem, Tamil Nadu, India.Introduction: The odontogenic keratocyst (OKC) is a histopathologiocally and behaviourally unique and specific entity. It is the most aggressive and recurrent of all the cysts and shows characteristics resembling both cyst and a tumour. The unique nature of OKC and the recent shift of OKC as a tumour made us evaluate yet another factor, Inducible nitric oxide synthase an (iNos) enzyme which has been implicated in the tumourigenesis of various neoplasms. Aims and Objects: The objective of the study was to analyse and compare the immunohistochemical expression of iNOS in odontogenic keratocysts (OKC’s) in variants of ameloblastoma affecting the oral cavity, to determine the neoplastic potential of OKC and to reinforce the classification of OKC as keratocystic odontogenic tumour. Materials and Methods: Thirty two specimens, eight specimens each in OKC, follicular ameloblastoma, plexiform ameloblastoma and unicystic ameloblastoma, taken from the Oral Pathology Department were randomly selected for this study and were evaluated for epithelial expression of iNOS by immunohistochemistry. Results: Epithelial immunoreactivity to iNOS was strongly positive in 93.5% of follicular ameloblastomas, 68.7% of plexiform ameloblastomas, 66.9% of odontogenic keratocysts and 66.2% of unicystic ameloblastomas. Conclusion: iNOS may be an important marker involved in the biological behaviour of OKC. Furthermore the presence of increased expression of iNOS in Follicular ameloblastomas followed by Plexiform ameloblastomas, OKCs and Unicystic ameloblastomas is yet another evidence to support that OKC could be considered as a neoplasm.https://jcdr.net/articles/PDF/5201/10288_CE(Ra)_F(Sh)_PF1(AJ_Sh)_PFA(Sh)_PF2(PAG).pdffollicularinoskcotokcplexiform and unicystic ameloblastoma |
| spellingShingle | Diana.H Maya.R Sekar.B Murali.S Ramesh. K Expression of Inducible Nitric Oxide Synthase in Keratocystic Odontogenic Tumour and Variants of Ameloblastoma – A Comparative Study Journal of Clinical and Diagnostic Research follicular inos kcot okc plexiform and unicystic ameloblastoma |
| title | Expression of Inducible Nitric Oxide Synthase in Keratocystic Odontogenic Tumour and Variants of Ameloblastoma – A Comparative Study |
| title_full | Expression of Inducible Nitric Oxide Synthase in Keratocystic Odontogenic Tumour and Variants of Ameloblastoma – A Comparative Study |
| title_fullStr | Expression of Inducible Nitric Oxide Synthase in Keratocystic Odontogenic Tumour and Variants of Ameloblastoma – A Comparative Study |
| title_full_unstemmed | Expression of Inducible Nitric Oxide Synthase in Keratocystic Odontogenic Tumour and Variants of Ameloblastoma – A Comparative Study |
| title_short | Expression of Inducible Nitric Oxide Synthase in Keratocystic Odontogenic Tumour and Variants of Ameloblastoma – A Comparative Study |
| title_sort | expression of inducible nitric oxide synthase in keratocystic odontogenic tumour and variants of ameloblastoma a comparative study |
| topic | follicular inos kcot okc plexiform and unicystic ameloblastoma |
| url | https://jcdr.net/articles/PDF/5201/10288_CE(Ra)_F(Sh)_PF1(AJ_Sh)_PFA(Sh)_PF2(PAG).pdf |
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