Folic acid and its role in female reproduction
Adequate folate status is a necessary condition for a normal pregnancy, the development of the fetus and child. Recent clinical studies have enhanced the classic recommendations for folic acid intake for the prevention of obstetric complications and fetal malformations. Subsidy of folic acid in the...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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IP Berlin A.V.
2014-08-01
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| Series: | Гинекология |
| Subjects: | |
| Online Access: | https://gynecology.orscience.ru/2079-5831/article/viewFile/28334/pdf |
| _version_ | 1819058440785362944 |
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| author | I V Kuznetsova V A Konovalov |
| author_facet | I V Kuznetsova V A Konovalov |
| author_sort | I V Kuznetsova |
| collection | DOAJ |
| description | Adequate folate status is a necessary condition for a normal pregnancy, the development of the fetus and child. Recent clinical studies have enhanced the classic recommendations for folic acid intake for the prevention of obstetric complications and fetal malformations. Subsidy of folic acid in the stage of pregravidal preparation and during pregnancy is an important factor in the prevention of miscarriage, premature birth, dysfunction of the fetoplacental complex, fetal malformations and birth weight of infants or immature children. The optimal dose of folate required to compensate for their lack (in addition to folate derived from food), ranges from 400 to 800 micrograms. The use of folic acid in combination with other vitamins and minerals needed during pregnancy has a better effect compared with monotherapy with folic acid. At the moment, there are drugs with structure that, instead of folic acid includes L-methylfolate. In Europe, a comparative, placebo-controlled study, which compared the effects of the use of L-methylfolate ([6S] -5-methyltetrahydrofolate) and folic acid in folate concentration in plasma and erythrocytes was recently held. These studies suggest that folic acid and methylfolate increase the concentration of folate in the blood at the same level, so it makes no sense to use methylfolate instead of folic acid, which has a broad evidence base. |
| first_indexed | 2024-12-21T13:55:15Z |
| format | Article |
| id | doaj.art-562f86cd56984f669110ef152b4857ce |
| institution | Directory Open Access Journal |
| issn | 2079-5696 2079-5831 |
| language | Russian |
| last_indexed | 2024-12-21T13:55:15Z |
| publishDate | 2014-08-01 |
| publisher | IP Berlin A.V. |
| record_format | Article |
| series | Гинекология |
| spelling | doaj.art-562f86cd56984f669110ef152b4857ce2022-12-21T19:01:34ZrusIP Berlin A.V.Гинекология2079-56962079-58312014-08-01164172325464Folic acid and its role in female reproductionI V KuznetsovaV A KonovalovAdequate folate status is a necessary condition for a normal pregnancy, the development of the fetus and child. Recent clinical studies have enhanced the classic recommendations for folic acid intake for the prevention of obstetric complications and fetal malformations. Subsidy of folic acid in the stage of pregravidal preparation and during pregnancy is an important factor in the prevention of miscarriage, premature birth, dysfunction of the fetoplacental complex, fetal malformations and birth weight of infants or immature children. The optimal dose of folate required to compensate for their lack (in addition to folate derived from food), ranges from 400 to 800 micrograms. The use of folic acid in combination with other vitamins and minerals needed during pregnancy has a better effect compared with monotherapy with folic acid. At the moment, there are drugs with structure that, instead of folic acid includes L-methylfolate. In Europe, a comparative, placebo-controlled study, which compared the effects of the use of L-methylfolate ([6S] -5-methyltetrahydrofolate) and folic acid in folate concentration in plasma and erythrocytes was recently held. These studies suggest that folic acid and methylfolate increase the concentration of folate in the blood at the same level, so it makes no sense to use methylfolate instead of folic acid, which has a broad evidence base.https://gynecology.orscience.ru/2079-5831/article/viewFile/28334/pdffolatefolic acidfolate deficiencya comparison of folic acid and l-methylfolatehyperhomocysteinemiamiscarriagevitamins in pregnancy |
| spellingShingle | I V Kuznetsova V A Konovalov Folic acid and its role in female reproduction Гинекология folate folic acid folate deficiency a comparison of folic acid and l-methylfolate hyperhomocysteinemia miscarriage vitamins in pregnancy |
| title | Folic acid and its role in female reproduction |
| title_full | Folic acid and its role in female reproduction |
| title_fullStr | Folic acid and its role in female reproduction |
| title_full_unstemmed | Folic acid and its role in female reproduction |
| title_short | Folic acid and its role in female reproduction |
| title_sort | folic acid and its role in female reproduction |
| topic | folate folic acid folate deficiency a comparison of folic acid and l-methylfolate hyperhomocysteinemia miscarriage vitamins in pregnancy |
| url | https://gynecology.orscience.ru/2079-5831/article/viewFile/28334/pdf |
| work_keys_str_mv | AT ivkuznetsova folicacidanditsroleinfemalereproduction AT vakonovalov folicacidanditsroleinfemalereproduction |