Role of proinflammatory mutations in peri-implantitis: systematic review and meta-analysis
Abstract Purpose To perform a systematic review and meta-analysis on the presence of inflammatory polymorphisms in patients with peri-implantitis (PI). PI is the main complication associated to dental implant therapy. Although its main risk factors are history of periodontitis, poor plaque control a...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-01-01
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| Series: | International Journal of Implant Dentistry |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40729-022-00400-y |
| _version_ | 1818954690211086336 |
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| author | Irene Lafuente-Ibáñez de Mendoza Amaia Setien-Olarra Ana María García-De la Fuente José Manuel Aguirre-Urizar Xabier Marichalar-Mendia |
| author_facet | Irene Lafuente-Ibáñez de Mendoza Amaia Setien-Olarra Ana María García-De la Fuente José Manuel Aguirre-Urizar Xabier Marichalar-Mendia |
| author_sort | Irene Lafuente-Ibáñez de Mendoza |
| collection | DOAJ |
| description | Abstract Purpose To perform a systematic review and meta-analysis on the presence of inflammatory polymorphisms in patients with peri-implantitis (PI). PI is the main complication associated to dental implant therapy. Although its main risk factors are history of periodontitis, poor plaque control and lack of regular maintenance, genetic susceptibility could also be a determinant factor for its appearance. Single nucleotide polymorphisms (SNP) are small mutations of the DNA that alter the osseointegration of implants. Inflammatory proteins participate in both destruction of the extracellular matrix and reabsorption of the alveolar bone. Methods A bibliographical research was made in PubMed, Scopus and Web of Science (keywords: “single nucleotide polymorphism”, “polymorphism”, “periimplantitis”, “SNP” and “implant failure”). Results There is a statistically significant association of peri-implant bone loss with the homozygotic model of IL-1β (− 511) (OR: 2.255; IC: 1.040–4.889). Conclusions Associations between inflammatory polymorphisms and PI must be taken with caution due to the heterogeneous methodological design, sample size and diagnostic criteria of the studies. Thus, more well-designed studies are needed that analyze the relationship between these and more SNP and PI. |
| first_indexed | 2024-12-20T10:26:10Z |
| format | Article |
| id | doaj.art-5630140109834522ab8672f204a38ac2 |
| institution | Directory Open Access Journal |
| issn | 2198-4034 |
| language | English |
| last_indexed | 2024-12-20T10:26:10Z |
| publishDate | 2022-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | International Journal of Implant Dentistry |
| spelling | doaj.art-5630140109834522ab8672f204a38ac22022-12-21T19:43:49ZengSpringerOpenInternational Journal of Implant Dentistry2198-40342022-01-01811910.1186/s40729-022-00400-yRole of proinflammatory mutations in peri-implantitis: systematic review and meta-analysisIrene Lafuente-Ibáñez de Mendoza0Amaia Setien-Olarra1Ana María García-De la Fuente2José Manuel Aguirre-Urizar3Xabier Marichalar-Mendia4Department of Stomatology II, University of the Basque Country (UPV/EHU)Department of Nursery I, University of the Basque Country (UPV/EHU)Department of Stomatology II, University of the Basque Country (UPV/EHU)Department of Stomatology II, University of the Basque Country (UPV/EHU)Department of Nursery I, University of the Basque Country (UPV/EHU)Abstract Purpose To perform a systematic review and meta-analysis on the presence of inflammatory polymorphisms in patients with peri-implantitis (PI). PI is the main complication associated to dental implant therapy. Although its main risk factors are history of periodontitis, poor plaque control and lack of regular maintenance, genetic susceptibility could also be a determinant factor for its appearance. Single nucleotide polymorphisms (SNP) are small mutations of the DNA that alter the osseointegration of implants. Inflammatory proteins participate in both destruction of the extracellular matrix and reabsorption of the alveolar bone. Methods A bibliographical research was made in PubMed, Scopus and Web of Science (keywords: “single nucleotide polymorphism”, “polymorphism”, “periimplantitis”, “SNP” and “implant failure”). Results There is a statistically significant association of peri-implant bone loss with the homozygotic model of IL-1β (− 511) (OR: 2.255; IC: 1.040–4.889). Conclusions Associations between inflammatory polymorphisms and PI must be taken with caution due to the heterogeneous methodological design, sample size and diagnostic criteria of the studies. Thus, more well-designed studies are needed that analyze the relationship between these and more SNP and PI.https://doi.org/10.1186/s40729-022-00400-yInflammationMeta-analysis peri-implantitisSingle nucleotide polymorphismSystematic review |
| spellingShingle | Irene Lafuente-Ibáñez de Mendoza Amaia Setien-Olarra Ana María García-De la Fuente José Manuel Aguirre-Urizar Xabier Marichalar-Mendia Role of proinflammatory mutations in peri-implantitis: systematic review and meta-analysis International Journal of Implant Dentistry Inflammation Meta-analysis peri-implantitis Single nucleotide polymorphism Systematic review |
| title | Role of proinflammatory mutations in peri-implantitis: systematic review and meta-analysis |
| title_full | Role of proinflammatory mutations in peri-implantitis: systematic review and meta-analysis |
| title_fullStr | Role of proinflammatory mutations in peri-implantitis: systematic review and meta-analysis |
| title_full_unstemmed | Role of proinflammatory mutations in peri-implantitis: systematic review and meta-analysis |
| title_short | Role of proinflammatory mutations in peri-implantitis: systematic review and meta-analysis |
| title_sort | role of proinflammatory mutations in peri implantitis systematic review and meta analysis |
| topic | Inflammation Meta-analysis peri-implantitis Single nucleotide polymorphism Systematic review |
| url | https://doi.org/10.1186/s40729-022-00400-y |
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