Effects of Hypoxen on Rat Myocardial Contractility after Severe Brain Injury
Objective: to study the effects of hypoxen on the myocardial contractility of rats with severe brain injury (BI).Materials and methods. Experiments were made on 69 male albino rats, by using the isolated isovolumetrically contracted heart procedure as described by E. T. Fallen et al. Post-BI cardiac...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2007-08-01
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| Series: | Общая реаниматология |
| Subjects: | |
| Online Access: | https://www.reanimatology.com/rmt/article/view/958 |
| _version_ | 1826562358573531136 |
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| author | V. V. Rusakov V. T. Dolgikh L. G. Shikunova |
| author_facet | V. V. Rusakov V. T. Dolgikh L. G. Shikunova |
| author_sort | V. V. Rusakov |
| collection | DOAJ |
| description | Objective: to study the effects of hypoxen on the myocardial contractility of rats with severe brain injury (BI).Materials and methods. Experiments were made on 69 male albino rats, by using the isolated isovolumetrically contracted heart procedure as described by E. T. Fallen et al. Post-BI cardiac functional reserves were estimated by a hypoxic test, followed by reoxygenation and a high-frequency rhythm load.Results. The intraperitoneal injection of hypoxen in a dose of 60 mg/kg one and 24 hours before severe BI contributed to increases in the rates of left myocardial contraction and relaxation in the injured rats. There was an increase in the resistance of the hearts in the animals receiving the drug before or after injury to hypoxia-reperfusion and high-frequency rhythm loads. The administration of the drug to the animals not only sustained the reserves of antioxidants, but even increased their blood levels.Conclusion. The results of the experiments using hypoxen confirmed the significance of pathogenetic factors, such as hypoxia and oxidative stress, in the development of posttraumatic myocardial contractile changes. |
| first_indexed | 2024-04-10T01:30:23Z |
| format | Article |
| id | doaj.art-56307c5645ff4e959855ce115635d39c |
| institution | Directory Open Access Journal |
| issn | 1813-9779 2411-7110 |
| language | English |
| last_indexed | 2025-03-14T09:46:48Z |
| publishDate | 2007-08-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj.art-56307c5645ff4e959855ce115635d39c2025-03-02T11:29:27ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102007-08-0134111410.15360/1813-9779-2007-4-64-82958Effects of Hypoxen on Rat Myocardial Contractility after Severe Brain InjuryV. V. Rusakov0V. T. Dolgikh1L. G. Shikunova2Omsk State Medical Academy, Russian Agency for Health CareOmsk State Medical Academy, Russian Agency for Health CareResearch Institute of General Reanimatology, Russian Academy of Medical SciencesObjective: to study the effects of hypoxen on the myocardial contractility of rats with severe brain injury (BI).Materials and methods. Experiments were made on 69 male albino rats, by using the isolated isovolumetrically contracted heart procedure as described by E. T. Fallen et al. Post-BI cardiac functional reserves were estimated by a hypoxic test, followed by reoxygenation and a high-frequency rhythm load.Results. The intraperitoneal injection of hypoxen in a dose of 60 mg/kg one and 24 hours before severe BI contributed to increases in the rates of left myocardial contraction and relaxation in the injured rats. There was an increase in the resistance of the hearts in the animals receiving the drug before or after injury to hypoxia-reperfusion and high-frequency rhythm loads. The administration of the drug to the animals not only sustained the reserves of antioxidants, but even increased their blood levels.Conclusion. The results of the experiments using hypoxen confirmed the significance of pathogenetic factors, such as hypoxia and oxidative stress, in the development of posttraumatic myocardial contractile changes.https://www.reanimatology.com/rmt/article/view/958brain injuryhearthypoxencorrection of functional and metabolic impairments |
| spellingShingle | V. V. Rusakov V. T. Dolgikh L. G. Shikunova Effects of Hypoxen on Rat Myocardial Contractility after Severe Brain Injury Общая реаниматология brain injury heart hypoxen correction of functional and metabolic impairments |
| title | Effects of Hypoxen on Rat Myocardial Contractility after Severe Brain Injury |
| title_full | Effects of Hypoxen on Rat Myocardial Contractility after Severe Brain Injury |
| title_fullStr | Effects of Hypoxen on Rat Myocardial Contractility after Severe Brain Injury |
| title_full_unstemmed | Effects of Hypoxen on Rat Myocardial Contractility after Severe Brain Injury |
| title_short | Effects of Hypoxen on Rat Myocardial Contractility after Severe Brain Injury |
| title_sort | effects of hypoxen on rat myocardial contractility after severe brain injury |
| topic | brain injury heart hypoxen correction of functional and metabolic impairments |
| url | https://www.reanimatology.com/rmt/article/view/958 |
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