Cardiac troponin and C-reactive protein for predicting all-cause and cardiovascular mortality in patients with chronic kidney disease: A meta-analysis
Elevated serum levels of cardiac troponin and C-reactive protein are associated with all-cause and cardiovascular mortality in patients with end-stage renal disease. However, the relationship between these two biomarker levels and mortality in patients with chronic kidney disease remains unclear. We...
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| Format: | Article |
| Language: | English |
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Elsevier España
2015-04-01
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| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322015000400301&lng=en&tlng=en |
| _version_ | 1811228480559382528 |
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| author | Wei-Jie Li Xu-Miao Chen Xiao-Ying Nie Jing Zhang Yun-Jiu Cheng Xiao-Xiong Lin Su-Hua Wu |
| author_facet | Wei-Jie Li Xu-Miao Chen Xiao-Ying Nie Jing Zhang Yun-Jiu Cheng Xiao-Xiong Lin Su-Hua Wu |
| author_sort | Wei-Jie Li |
| collection | DOAJ |
| description | Elevated serum levels of cardiac troponin and C-reactive protein are associated with all-cause and cardiovascular mortality in patients with end-stage renal disease. However, the relationship between these two biomarker levels and mortality in patients with chronic kidney disease remains unclear. We conducted a meta-analysis to quantify the association of cardiac troponin and C-reactive protein levels with all-cause and cardiovascular mortality in patients with chronic kidney disease. Relevant studies were identified by searching the MEDLINE database through November 2013. Studies were included in the meta-analysis if they reported the long-term all-cause or cardiovascular mortality of chronic kidney disease patients with abnormally elevated serum levels of cardiac troponin or C-reactive protein. Summary estimates of association were obtained using a random-effects model. Thirty-two studies met our inclusion criteria. From the pooled analysis, cardiac troponin and C-reactive protein were significantly associated with all-cause (HR 2.93, 95% CI 1.97-4.33 and HR 1.21, 95% CI 1.14-1.29, respectively) and cardiovascular (HR 3.27, 95% CI 1.67-6.41 and HR 1.19, 95% CI 1.10-1.28, respectively) mortality. In the subgroup analysis of cardiac troponin and C-reactive protein, significant heterogeneities were found among the subgroups of population for renal replacement therapy and for the proportion of smokers and the C-reactive protein analysis method. Elevated serum levels of cardiac troponin and C-reactive protein are significant associated with higher risks of all-cause and cardiovascular mortality in patients with chronic kidney disease. Further studies are warranted to explore the risk stratification in chronic kidney disease patients. |
| first_indexed | 2024-04-12T09:58:32Z |
| format | Article |
| id | doaj.art-5630a224dff146c990d599ea1f2ecd8d |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-04-12T09:58:32Z |
| publishDate | 2015-04-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-5630a224dff146c990d599ea1f2ecd8d2022-12-22T03:37:37ZengElsevier EspañaClinics1980-53222015-04-0170430131110.6061/clinics/2015(04)14S1807-59322015000400301Cardiac troponin and C-reactive protein for predicting all-cause and cardiovascular mortality in patients with chronic kidney disease: A meta-analysisWei-Jie LiXu-Miao ChenXiao-Ying NieJing ZhangYun-Jiu ChengXiao-Xiong LinSu-Hua WuElevated serum levels of cardiac troponin and C-reactive protein are associated with all-cause and cardiovascular mortality in patients with end-stage renal disease. However, the relationship between these two biomarker levels and mortality in patients with chronic kidney disease remains unclear. We conducted a meta-analysis to quantify the association of cardiac troponin and C-reactive protein levels with all-cause and cardiovascular mortality in patients with chronic kidney disease. Relevant studies were identified by searching the MEDLINE database through November 2013. Studies were included in the meta-analysis if they reported the long-term all-cause or cardiovascular mortality of chronic kidney disease patients with abnormally elevated serum levels of cardiac troponin or C-reactive protein. Summary estimates of association were obtained using a random-effects model. Thirty-two studies met our inclusion criteria. From the pooled analysis, cardiac troponin and C-reactive protein were significantly associated with all-cause (HR 2.93, 95% CI 1.97-4.33 and HR 1.21, 95% CI 1.14-1.29, respectively) and cardiovascular (HR 3.27, 95% CI 1.67-6.41 and HR 1.19, 95% CI 1.10-1.28, respectively) mortality. In the subgroup analysis of cardiac troponin and C-reactive protein, significant heterogeneities were found among the subgroups of population for renal replacement therapy and for the proportion of smokers and the C-reactive protein analysis method. Elevated serum levels of cardiac troponin and C-reactive protein are significant associated with higher risks of all-cause and cardiovascular mortality in patients with chronic kidney disease. Further studies are warranted to explore the risk stratification in chronic kidney disease patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322015000400301&lng=en&tlng=enRenal insufficiencyMortalityTroponinC-reactive proteinMeta-analysis |
| spellingShingle | Wei-Jie Li Xu-Miao Chen Xiao-Ying Nie Jing Zhang Yun-Jiu Cheng Xiao-Xiong Lin Su-Hua Wu Cardiac troponin and C-reactive protein for predicting all-cause and cardiovascular mortality in patients with chronic kidney disease: A meta-analysis Clinics Renal insufficiency Mortality Troponin C-reactive protein Meta-analysis |
| title | Cardiac troponin and C-reactive protein for predicting all-cause and cardiovascular mortality in patients with chronic kidney disease: A meta-analysis |
| title_full | Cardiac troponin and C-reactive protein for predicting all-cause and cardiovascular mortality in patients with chronic kidney disease: A meta-analysis |
| title_fullStr | Cardiac troponin and C-reactive protein for predicting all-cause and cardiovascular mortality in patients with chronic kidney disease: A meta-analysis |
| title_full_unstemmed | Cardiac troponin and C-reactive protein for predicting all-cause and cardiovascular mortality in patients with chronic kidney disease: A meta-analysis |
| title_short | Cardiac troponin and C-reactive protein for predicting all-cause and cardiovascular mortality in patients with chronic kidney disease: A meta-analysis |
| title_sort | cardiac troponin and c reactive protein for predicting all cause and cardiovascular mortality in patients with chronic kidney disease a meta analysis |
| topic | Renal insufficiency Mortality Troponin C-reactive protein Meta-analysis |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322015000400301&lng=en&tlng=en |
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