KDM5c Promotes Colon Cancer Cell Proliferation Through the FBXW7-c-Jun Regulatory Axis

KDM5c Promotes Colon Cancer Cell Proliferation Through the FBXW7-c-Jun Regulatory Axis

KDM5c is a histone demethylase that specifically demethylates trimethylated and dimethylated H3 Lys-4 to play a central role in transcriptional repression. C-Jun is a proto-oncogene and promotes cell proliferation when ectopically accumulated, but can be ubiquitinated by SCF (FBXW7), leading to its...

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Bibliographic Details
Main Authors: Haishan Lin, Nina Ma, Lei Zhao, Guowei Yang, Bangwei Cao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Oncology
Subjects:
KDM5c
c-Jun oncogene
colon cancer cell
FBXW7
epigenetic modifier
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.535449/full

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