The relationship between hemoglobin and triglycerides in moyamoya disease: A cross-sectional study
Hemoglobin (Hb) and lipid metabolism are critical in the pathophysiology of moyamoya disease (MMD), and Hb and triglycerides (TGs) both play roles in the development of cerebrovascular illness. However, there is little evidence of a link between Hb and TGs in patients with MMD. This study aimed to d...
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.994341/full |
| _version_ | 1798002151120699392 |
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| author | Yu Su Genhua Li Huihui Zhao Song Feng Yan Lu Jilan Liu Chao Chen Feng Jin |
| author_facet | Yu Su Genhua Li Huihui Zhao Song Feng Yan Lu Jilan Liu Chao Chen Feng Jin |
| author_sort | Yu Su |
| collection | DOAJ |
| description | Hemoglobin (Hb) and lipid metabolism are critical in the pathophysiology of moyamoya disease (MMD), and Hb and triglycerides (TGs) both play roles in the development of cerebrovascular illness. However, there is little evidence of a link between Hb and TGs in patients with MMD. This study aimed to determine the association between Hb and TGs in patients who had recently been diagnosed with MMD. From March 2013 to December 2018, 337 patients clinically diagnosed with MMD were admitted to our hospital. Among these, 235 were selected for analysis in this retrospective, cross-sectional study. Each patient's clinical features were documented. For analysis, we used univariate analysis, smoothed-curve fitting, and multivariable, piecewise linear regression. Overall, the mean±standard deviation patient age was 48.14 ± 11.24 years, 44.68% were men, and the mean Hb concentration was 135.72 ± 18.99 g/L. After controlling for relevant confounders, smoothed-curve fitting revealed a nonlinear association between the Hb and TG concentrations (P = 0.0448). When the Hb concentration was below 141 g/L, multivariate piecewise linear regression analysis revealed a significant association between the Hb and TG concentrations [β: 0.01, 95% confidence interval (CI): 0.00, 0.01; P = 0.0182], although the association disappeared above this threshold (β:−0.00, 95% CI:−0.01, 0.01; P = 0.4429). In individuals newly diagnosed with MMD, there is a significant correlation between Hb and TGs, which may be connected to MMD pathogenesis. |
| first_indexed | 2024-04-11T11:47:36Z |
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| id | doaj.art-56322eec55ad4935bc06e10ce8147983 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-11T11:47:36Z |
| publishDate | 2022-09-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-56322eec55ad4935bc06e10ce81479832022-12-22T04:25:29ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-09-011310.3389/fneur.2022.994341994341The relationship between hemoglobin and triglycerides in moyamoya disease: A cross-sectional studyYu Su0Genhua Li1Huihui Zhao2Song Feng3Yan Lu4Jilan Liu5Chao Chen6Feng Jin7Clinical Medical College, Jining Medical University, Jining, ChinaDepartment of Neurosurgery, Affiliated Hospital of Jining Medical University & Shandong Provincial Key Laboratory of Stem Cells and Neuro-Oncology, Jining, ChinaDepartment of Neurosurgery, Affiliated Hospital of Jining Medical University & Shandong Provincial Key Laboratory of Stem Cells and Neuro-Oncology, Jining, ChinaDepartment of Neurosurgery, Affiliated Hospital of Jining Medical University & Shandong Provincial Key Laboratory of Stem Cells and Neuro-Oncology, Jining, ChinaMedical Research Center, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, ChinaMedical Research Center, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, ChinaClinical Medical College, Jining Medical University, Jining, ChinaDepartment of Neurosurgery, Affiliated Hospital of Jining Medical University & Shandong Provincial Key Laboratory of Stem Cells and Neuro-Oncology, Jining, ChinaHemoglobin (Hb) and lipid metabolism are critical in the pathophysiology of moyamoya disease (MMD), and Hb and triglycerides (TGs) both play roles in the development of cerebrovascular illness. However, there is little evidence of a link between Hb and TGs in patients with MMD. This study aimed to determine the association between Hb and TGs in patients who had recently been diagnosed with MMD. From March 2013 to December 2018, 337 patients clinically diagnosed with MMD were admitted to our hospital. Among these, 235 were selected for analysis in this retrospective, cross-sectional study. Each patient's clinical features were documented. For analysis, we used univariate analysis, smoothed-curve fitting, and multivariable, piecewise linear regression. Overall, the mean±standard deviation patient age was 48.14 ± 11.24 years, 44.68% were men, and the mean Hb concentration was 135.72 ± 18.99 g/L. After controlling for relevant confounders, smoothed-curve fitting revealed a nonlinear association between the Hb and TG concentrations (P = 0.0448). When the Hb concentration was below 141 g/L, multivariate piecewise linear regression analysis revealed a significant association between the Hb and TG concentrations [β: 0.01, 95% confidence interval (CI): 0.00, 0.01; P = 0.0182], although the association disappeared above this threshold (β:−0.00, 95% CI:−0.01, 0.01; P = 0.4429). In individuals newly diagnosed with MMD, there is a significant correlation between Hb and TGs, which may be connected to MMD pathogenesis.https://www.frontiersin.org/articles/10.3389/fneur.2022.994341/fullmoyamoya diseaseinternal carotid arteriescerebrovascular diseasetriglycerideshemoglobin |
| spellingShingle | Yu Su Genhua Li Huihui Zhao Song Feng Yan Lu Jilan Liu Chao Chen Feng Jin The relationship between hemoglobin and triglycerides in moyamoya disease: A cross-sectional study Frontiers in Neurology moyamoya disease internal carotid arteries cerebrovascular disease triglycerides hemoglobin |
| title | The relationship between hemoglobin and triglycerides in moyamoya disease: A cross-sectional study |
| title_full | The relationship between hemoglobin and triglycerides in moyamoya disease: A cross-sectional study |
| title_fullStr | The relationship between hemoglobin and triglycerides in moyamoya disease: A cross-sectional study |
| title_full_unstemmed | The relationship between hemoglobin and triglycerides in moyamoya disease: A cross-sectional study |
| title_short | The relationship between hemoglobin and triglycerides in moyamoya disease: A cross-sectional study |
| title_sort | relationship between hemoglobin and triglycerides in moyamoya disease a cross sectional study |
| topic | moyamoya disease internal carotid arteries cerebrovascular disease triglycerides hemoglobin |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.994341/full |
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