Clinical T Cell Receptor Repertoire Deep Sequencing and Analysis: An Application to Monitor Immune Reconstitution Following Cord Blood Transplantation

Clinical T Cell Receptor Repertoire Deep Sequencing and Analysis: An Application to Monitor Immune Reconstitution Following Cord Blood Transplantation

Spectratyping assays are well recognized as the clinical gold standard for assessing the T cell receptor (TCR) repertoire in haematopoietic stem cell transplant (HSCT) recipients. These assays use length distributions of the hyper variable complementarity-determining region 3 (CDR3) to characterize...

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Bibliographic Details
Main Authors: Athina Soragia Gkazi, Ben K Margetts, Teresa Attenborough, Lana Mhaldien, Joseph F. Standing, Theres Oakes, James M. Heather, John Booth, Marlene Pasquet, Robert Chiesa, Paul Veys, Nigel Klein, Benny Chain, Robin Callard, Stuart P. Adams
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
T cell
haematopoietic stem cell transplant
next generation sequencing
T cell receptor
CDR3
clonotypes
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02547/full

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