Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy
Multiple sclerosis (MS) is a chronic inflammatory disease characterized by central nervous system (CNS) lesions that can lead to severe physical or cognitive disability as well as neurological defects. Although the etiology and pathogenesis of MS remains unclear, the present documents illustrate tha...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Royan Institute (ACECR), Tehran
2017-01-01
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| Series: | Cell Journal |
| Subjects: | |
| Online Access: | http://celljournal.org/journal/article/9155/download |
| _version_ | 1811197592475795456 |
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| author | Nazem Ghasemi, Shahnaz Razavi, Elham Nikzad |
| author_facet | Nazem Ghasemi, Shahnaz Razavi, Elham Nikzad |
| author_sort | Nazem Ghasemi, |
| collection | DOAJ |
| description | Multiple sclerosis (MS) is a chronic inflammatory disease characterized by central nervous system (CNS) lesions that can lead to severe physical or cognitive disability as well as neurological defects. Although the etiology and pathogenesis of MS remains unclear, the present documents illustrate that the cause of MS is multifactorial and include genetic predisposition together with environmental factors such as exposure to infectious agents, vitamin deficiencies, and smoking. These agents are able to trigger a cascade of events in the immune system which lead to neuronal cell death accompanied by nerve demyelination and neuronal dysfunction. Conventional therapies for MS are based on the use of anti-inflammatory and immunomodulatory drugs, but these treatments are not able to stop the destruction of nerve tissue. Thus, other strategies such as stem cell transplantation have been proposed for the treatment of MS. Overall, it is important that neurologists be aware of current information regarding the pathogenesis, etiology, diagnostic criteria, and treatment of MS. Thus, this issue has been discussed according to recent available information. |
| first_indexed | 2024-04-12T01:17:33Z |
| format | Article |
| id | doaj.art-5633ef82a00b4c57a2b148297ae81aa3 |
| institution | Directory Open Access Journal |
| issn | 2228-5806 2228-5814 |
| language | English |
| last_indexed | 2024-04-12T01:17:33Z |
| publishDate | 2017-01-01 |
| publisher | Royan Institute (ACECR), Tehran |
| record_format | Article |
| series | Cell Journal |
| spelling | doaj.art-5633ef82a00b4c57a2b148297ae81aa32022-12-22T03:53:54ZengRoyan Institute (ACECR), TehranCell Journal2228-58062228-58142017-01-01191110Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based TherapyNazem Ghasemi, 0Shahnaz Razavi, 1Elham Nikzad2Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranJesus Son of Mary Hospital, Isfahan University of Medical Sciences, Isfahan, IranMultiple sclerosis (MS) is a chronic inflammatory disease characterized by central nervous system (CNS) lesions that can lead to severe physical or cognitive disability as well as neurological defects. Although the etiology and pathogenesis of MS remains unclear, the present documents illustrate that the cause of MS is multifactorial and include genetic predisposition together with environmental factors such as exposure to infectious agents, vitamin deficiencies, and smoking. These agents are able to trigger a cascade of events in the immune system which lead to neuronal cell death accompanied by nerve demyelination and neuronal dysfunction. Conventional therapies for MS are based on the use of anti-inflammatory and immunomodulatory drugs, but these treatments are not able to stop the destruction of nerve tissue. Thus, other strategies such as stem cell transplantation have been proposed for the treatment of MS. Overall, it is important that neurologists be aware of current information regarding the pathogenesis, etiology, diagnostic criteria, and treatment of MS. Thus, this issue has been discussed according to recent available information.http://celljournal.org/journal/article/9155/downloadMultiple SclerosisCell TherapyEtiologyDemyelination |
| spellingShingle | Nazem Ghasemi, Shahnaz Razavi, Elham Nikzad Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy Cell Journal Multiple Sclerosis Cell Therapy Etiology Demyelination |
| title | Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy |
| title_full | Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy |
| title_fullStr | Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy |
| title_full_unstemmed | Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy |
| title_short | Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy |
| title_sort | multiple sclerosis pathogenesis symptoms diagnoses and cell based therapy |
| topic | Multiple Sclerosis Cell Therapy Etiology Demyelination |
| url | http://celljournal.org/journal/article/9155/download |
| work_keys_str_mv | AT nazemghasemi multiplesclerosispathogenesissymptomsdiagnosesandcellbasedtherapy AT shahnazrazavi multiplesclerosispathogenesissymptomsdiagnosesandcellbasedtherapy AT elhamnikzad multiplesclerosispathogenesissymptomsdiagnosesandcellbasedtherapy |