Embracing complexity in Drosophila cancer models
Cancer continues to be a leading cause of death worldwide, largely due to metastases and cachexia. It is a complex disease that is commonly associated with a variety of comorbidities. With global increases in ageing populations and obesity, multimorbidity is a rapidly growing clinical issue in the c...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
The Company of Biologists
2022-03-01
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| Series: | Disease Models & Mechanisms |
| Subjects: | |
| Online Access: | http://dmm.biologists.org/content/15/3/dmm049513 |
| _version_ | 1818211588921884672 |
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| author | Courtney Choutka Cecilia Cabrera Susumu Hirabayashi |
| author_facet | Courtney Choutka Cecilia Cabrera Susumu Hirabayashi |
| author_sort | Courtney Choutka |
| collection | DOAJ |
| description | Cancer continues to be a leading cause of death worldwide, largely due to metastases and cachexia. It is a complex disease that is commonly associated with a variety of comorbidities. With global increases in ageing populations and obesity, multimorbidity is a rapidly growing clinical issue in the context of cancer. Cancer is also genetically heterogeneous, with a tumour's unique profile determining its incidence of metastasis, degree of cachexia and response to therapeutics. These complexities of human cancer are difficult to replicate in animal models and are, in part, responsible for the failures in translational cancer research. In this Perspective, we highlight the fruit fly, Drosophila melanogaster, as a powerful model organism to investigate multimorbidity and tumour diversity. We also highlight how harnessing these complexities in Drosophila can, potentially, enhance cancer research and advance therapeutic discoveries. |
| first_indexed | 2024-12-12T05:34:54Z |
| format | Article |
| id | doaj.art-5634f4bb17fb495291e07896f5b25947 |
| institution | Directory Open Access Journal |
| issn | 1754-8403 1754-8411 |
| language | English |
| last_indexed | 2024-12-12T05:34:54Z |
| publishDate | 2022-03-01 |
| publisher | The Company of Biologists |
| record_format | Article |
| series | Disease Models & Mechanisms |
| spelling | doaj.art-5634f4bb17fb495291e07896f5b259472022-12-22T00:36:10ZengThe Company of BiologistsDisease Models & Mechanisms1754-84031754-84112022-03-0115310.1242/dmm.049513049513Embracing complexity in Drosophila cancer modelsCourtney Choutka0Cecilia Cabrera1Susumu Hirabayashi2 Medical Research Council London Institute of Medical Sciences, Du Cane Road, London W12 0NN, United Kingdom Medical Research Council London Institute of Medical Sciences, Du Cane Road, London W12 0NN, United Kingdom Medical Research Council London Institute of Medical Sciences, Du Cane Road, London W12 0NN, United Kingdom Cancer continues to be a leading cause of death worldwide, largely due to metastases and cachexia. It is a complex disease that is commonly associated with a variety of comorbidities. With global increases in ageing populations and obesity, multimorbidity is a rapidly growing clinical issue in the context of cancer. Cancer is also genetically heterogeneous, with a tumour's unique profile determining its incidence of metastasis, degree of cachexia and response to therapeutics. These complexities of human cancer are difficult to replicate in animal models and are, in part, responsible for the failures in translational cancer research. In this Perspective, we highlight the fruit fly, Drosophila melanogaster, as a powerful model organism to investigate multimorbidity and tumour diversity. We also highlight how harnessing these complexities in Drosophila can, potentially, enhance cancer research and advance therapeutic discoveries.http://dmm.biologists.org/content/15/3/dmm049513ageingcachexiacancerdrosophilametastasismultimorbidityobesitytherapeuticstumour diversity |
| spellingShingle | Courtney Choutka Cecilia Cabrera Susumu Hirabayashi Embracing complexity in Drosophila cancer models Disease Models & Mechanisms ageing cachexia cancer drosophila metastasis multimorbidity obesity therapeutics tumour diversity |
| title | Embracing complexity in Drosophila cancer models |
| title_full | Embracing complexity in Drosophila cancer models |
| title_fullStr | Embracing complexity in Drosophila cancer models |
| title_full_unstemmed | Embracing complexity in Drosophila cancer models |
| title_short | Embracing complexity in Drosophila cancer models |
| title_sort | embracing complexity in drosophila cancer models |
| topic | ageing cachexia cancer drosophila metastasis multimorbidity obesity therapeutics tumour diversity |
| url | http://dmm.biologists.org/content/15/3/dmm049513 |
| work_keys_str_mv | AT courtneychoutka embracingcomplexityindrosophilacancermodels AT ceciliacabrera embracingcomplexityindrosophilacancermodels AT susumuhirabayashi embracingcomplexityindrosophilacancermodels |