Effect of protein hydrolysates from carp (Cyprinus carpio) skin gelatine on oxidative stress biomarkers and other blood parameters in healthy rats
Carp skin gelatine hydrolysates can be a potential source of bioactive peptides with strong antioxidant properties tested in vitro, but there is no information on in vivo activity. Therefore, the objective of this study was to determine the ability of an antioxidant carp skin gelatine hydrolysate to...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-09-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464619303299 |
| _version_ | 1819292705429127168 |
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| author | Joanna Tkaczewska Barbara Borczak Ewa Piątkowska Joanna Kapusta-Duch Małgorzata Morawska Tomasz Czech |
| author_facet | Joanna Tkaczewska Barbara Borczak Ewa Piątkowska Joanna Kapusta-Duch Małgorzata Morawska Tomasz Czech |
| author_sort | Joanna Tkaczewska |
| collection | DOAJ |
| description | Carp skin gelatine hydrolysates can be a potential source of bioactive peptides with strong antioxidant properties tested in vitro, but there is no information on in vivo activity. Therefore, the objective of this study was to determine the ability of an antioxidant carp skin gelatine hydrolysate to attenuate plasma/serum levels of some oxidative stress markers in healthy adult Wistar rats. Analysis of hydrolysate included safety in an animal organism (haematological blood parameters, CRP, hepatic and kidney function), biological value (BV, TD, NPU), evaluation of the lipid profile (TC, LDL-C, HDL-C, TAG) and antioxidant blood status (TAS, MDA, GSR, HO-1). The results indicate that fish protein hydrolysates are safe for laboratory animals, but have very low biological value. An increase in glutathione reductase activity in the blood serum of healthy animals fed with carp skin gelatine hydrolysate supplements is a promising indicator of its antioxidant in vivo properties. |
| first_indexed | 2024-12-24T03:58:47Z |
| format | Article |
| id | doaj.art-563774f0b5bf460284d22563368cfbd2 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-24T03:58:47Z |
| publishDate | 2019-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-563774f0b5bf460284d22563368cfbd22022-12-21T17:16:22ZengElsevierJournal of Functional Foods1756-46462019-09-0160Effect of protein hydrolysates from carp (Cyprinus carpio) skin gelatine on oxidative stress biomarkers and other blood parameters in healthy ratsJoanna Tkaczewska0Barbara Borczak1Ewa Piątkowska2Joanna Kapusta-Duch3Małgorzata Morawska4Tomasz Czech5Department of Animal Product Technology, Faculty of Food Technology, University of Agriculture in Cracow, Poland; Corresponding author at: ul. Balicka 122, 30-149 Kraków, Poland.Department of Human Nutrition, Faculty of Food Technology, University of Agriculture in Cracow, PolandDepartment of Human Nutrition, Faculty of Food Technology, University of Agriculture in Cracow, PolandDepartment of Human Nutrition, Faculty of Food Technology, University of Agriculture in Cracow, PolandDepartment of Sports Medicine & Human Nutrition, Institute of Human Physiology, University School of Physical Education in Krakow, Cracow, PolandDepartment of Agricultural and Environmental Chemistry, Faculty of Agriculture and Economics, University of Agriculture in Krakow, Cracow, PolandCarp skin gelatine hydrolysates can be a potential source of bioactive peptides with strong antioxidant properties tested in vitro, but there is no information on in vivo activity. Therefore, the objective of this study was to determine the ability of an antioxidant carp skin gelatine hydrolysate to attenuate plasma/serum levels of some oxidative stress markers in healthy adult Wistar rats. Analysis of hydrolysate included safety in an animal organism (haematological blood parameters, CRP, hepatic and kidney function), biological value (BV, TD, NPU), evaluation of the lipid profile (TC, LDL-C, HDL-C, TAG) and antioxidant blood status (TAS, MDA, GSR, HO-1). The results indicate that fish protein hydrolysates are safe for laboratory animals, but have very low biological value. An increase in glutathione reductase activity in the blood serum of healthy animals fed with carp skin gelatine hydrolysate supplements is a promising indicator of its antioxidant in vivo properties.http://www.sciencedirect.com/science/article/pii/S1756464619303299CarpGelatineAntioxidant activityBioactive peptideIn vivo study |
| spellingShingle | Joanna Tkaczewska Barbara Borczak Ewa Piątkowska Joanna Kapusta-Duch Małgorzata Morawska Tomasz Czech Effect of protein hydrolysates from carp (Cyprinus carpio) skin gelatine on oxidative stress biomarkers and other blood parameters in healthy rats Journal of Functional Foods Carp Gelatine Antioxidant activity Bioactive peptide In vivo study |
| title | Effect of protein hydrolysates from carp (Cyprinus carpio) skin gelatine on oxidative stress biomarkers and other blood parameters in healthy rats |
| title_full | Effect of protein hydrolysates from carp (Cyprinus carpio) skin gelatine on oxidative stress biomarkers and other blood parameters in healthy rats |
| title_fullStr | Effect of protein hydrolysates from carp (Cyprinus carpio) skin gelatine on oxidative stress biomarkers and other blood parameters in healthy rats |
| title_full_unstemmed | Effect of protein hydrolysates from carp (Cyprinus carpio) skin gelatine on oxidative stress biomarkers and other blood parameters in healthy rats |
| title_short | Effect of protein hydrolysates from carp (Cyprinus carpio) skin gelatine on oxidative stress biomarkers and other blood parameters in healthy rats |
| title_sort | effect of protein hydrolysates from carp cyprinus carpio skin gelatine on oxidative stress biomarkers and other blood parameters in healthy rats |
| topic | Carp Gelatine Antioxidant activity Bioactive peptide In vivo study |
| url | http://www.sciencedirect.com/science/article/pii/S1756464619303299 |
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