CAR-T Cells in the Treatment of Ovarian Cancer: A Promising Cell Therapy
Ovarian cancer (OC) is among the most common gynecologic malignancies with a poor prognosis and a high mortality rate. Most patients are diagnosed at an advanced stage (stage III or IV), with 5-year survival rates ranging from 25% to 47% worldwide. Surgical resection and first-line chemotherapy are...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/3/465 |
| _version_ | 1827751011764142080 |
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| author | Xi-Wen Zhang Yi-Shi Wu Tian-Min Xu Man-Hua Cui |
| author_facet | Xi-Wen Zhang Yi-Shi Wu Tian-Min Xu Man-Hua Cui |
| author_sort | Xi-Wen Zhang |
| collection | DOAJ |
| description | Ovarian cancer (OC) is among the most common gynecologic malignancies with a poor prognosis and a high mortality rate. Most patients are diagnosed at an advanced stage (stage III or IV), with 5-year survival rates ranging from 25% to 47% worldwide. Surgical resection and first-line chemotherapy are the main treatment modalities for OC. However, patients usually relapse within a few years of initial treatment due to resistance to chemotherapy. Cell-based therapies, particularly adoptive T-cell therapy and chimeric antigen receptor T (CAR-T) cell therapy, represent an alternative immunotherapy approach with great potential for hematologic malignancies. However, the use of CAR-T-cell therapy for the treatment of OC is still associated with several difficulties. In this review, we comprehensively discuss recent innovations in CAR-T-cell engineering to improve clinical efficacy, as well as strategies to overcome the limitations of CAR-T-cell therapy in OC. |
| first_indexed | 2024-03-11T06:52:29Z |
| format | Article |
| id | doaj.art-563b66f6910a448a9d0814b1f5c861c3 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T06:52:29Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-563b66f6910a448a9d0814b1f5c861c32023-11-17T09:51:40ZengMDPI AGBiomolecules2218-273X2023-03-0113346510.3390/biom13030465CAR-T Cells in the Treatment of Ovarian Cancer: A Promising Cell TherapyXi-Wen Zhang0Yi-Shi Wu1Tian-Min Xu2Man-Hua Cui3Department of Gynecology, The Second Hospital of Jilin University, Changchun 130000, ChinaDepartment of Gynecology, The Second Hospital of Jilin University, Changchun 130000, ChinaDepartment of Gynecology, The Second Hospital of Jilin University, Changchun 130000, ChinaDepartment of Gynecology, The Second Hospital of Jilin University, Changchun 130000, ChinaOvarian cancer (OC) is among the most common gynecologic malignancies with a poor prognosis and a high mortality rate. Most patients are diagnosed at an advanced stage (stage III or IV), with 5-year survival rates ranging from 25% to 47% worldwide. Surgical resection and first-line chemotherapy are the main treatment modalities for OC. However, patients usually relapse within a few years of initial treatment due to resistance to chemotherapy. Cell-based therapies, particularly adoptive T-cell therapy and chimeric antigen receptor T (CAR-T) cell therapy, represent an alternative immunotherapy approach with great potential for hematologic malignancies. However, the use of CAR-T-cell therapy for the treatment of OC is still associated with several difficulties. In this review, we comprehensively discuss recent innovations in CAR-T-cell engineering to improve clinical efficacy, as well as strategies to overcome the limitations of CAR-T-cell therapy in OC.https://www.mdpi.com/2218-273X/13/3/465ovarian cancerCARCAR-Timmunotherapy |
| spellingShingle | Xi-Wen Zhang Yi-Shi Wu Tian-Min Xu Man-Hua Cui CAR-T Cells in the Treatment of Ovarian Cancer: A Promising Cell Therapy Biomolecules ovarian cancer CAR CAR-T immunotherapy |
| title | CAR-T Cells in the Treatment of Ovarian Cancer: A Promising Cell Therapy |
| title_full | CAR-T Cells in the Treatment of Ovarian Cancer: A Promising Cell Therapy |
| title_fullStr | CAR-T Cells in the Treatment of Ovarian Cancer: A Promising Cell Therapy |
| title_full_unstemmed | CAR-T Cells in the Treatment of Ovarian Cancer: A Promising Cell Therapy |
| title_short | CAR-T Cells in the Treatment of Ovarian Cancer: A Promising Cell Therapy |
| title_sort | car t cells in the treatment of ovarian cancer a promising cell therapy |
| topic | ovarian cancer CAR CAR-T immunotherapy |
| url | https://www.mdpi.com/2218-273X/13/3/465 |
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