Exposure to zinc induces lysosomal-mitochondrial axis-mediated apoptosis in PK-15 cells

Exposure to zinc induces lysosomal-mitochondrial axis-mediated apoptosis in PK-15 cells

Zinc (Zn), a kind of metallic element, can cause poisonous effects on host physiology when its excess exposure. Lysosomes and mitochondria are the toxic targets of heavy metals, and the lysosomal-mitochondrial axis is also verified to take part in apoptosis, but the related underlying mechanisms in...

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Bibliographic Details
Main Authors: Qingwen Yang, Yudong Fang, Chuanshi Zhang, Xuesong Liu, Youhua Wu, Yi Zhang, Junjie Yang, Kang Yong
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Zinc
Apoptosis
Cathepsin D
Lysosomal-mitochondrial axis
PK-15 cell
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651322005565

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