Sex-Related Motor Deficits in the Tau-P301L Mouse Model
The contribution of mouse models for basic and translational research at different levels is important to understand neurodegenerative diseases, including tauopathies, by studying the alterations in the corresponding mouse models in detail. Moreover, several studies demonstrated that pathological as...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/9/1160 |
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| author | Luana Cristina Camargo Dominik Honold Robert Bauer N. Jon Shah Karl-Josef Langen Dieter Willbold Janine Kutzsche Antje Willuweit Sarah Schemmert |
| author_facet | Luana Cristina Camargo Dominik Honold Robert Bauer N. Jon Shah Karl-Josef Langen Dieter Willbold Janine Kutzsche Antje Willuweit Sarah Schemmert |
| author_sort | Luana Cristina Camargo |
| collection | DOAJ |
| description | The contribution of mouse models for basic and translational research at different levels is important to understand neurodegenerative diseases, including tauopathies, by studying the alterations in the corresponding mouse models in detail. Moreover, several studies demonstrated that pathological as well as behavioral changes are influenced by the sex. For this purpose, we performed an in-depth characterization of the behavioral alterations in the transgenic Tau-P301L mouse model. Sex-matched wild type and homozygous Tau-P301L mice were tested in a battery of behavioral tests at different ages. Tau-P301L male mice showed olfactory and motor deficits as well as increased Tau pathology, which was not observed in Tau-P301L female mice. Both Tau-P301L male and female mice had phenotypic alterations in the SHIRPA test battery and cognitive deficits in the novel object recognition test. This study demonstrated that Tau-P301L mice have phenotypic alterations, which are in line with the histological changes and with a sex-dependent performance in those tests. Summarized, the Tau-P301L mouse model shows phenotypic alterations due to the presence of neurofibrillary tangles in the brain. |
| first_indexed | 2024-03-10T07:52:13Z |
| format | Article |
| id | doaj.art-563e379591214109949a1abbd48d6ec3 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T07:52:13Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-563e379591214109949a1abbd48d6ec32023-11-22T12:07:55ZengMDPI AGBiomedicines2227-90592021-09-0199116010.3390/biomedicines9091160Sex-Related Motor Deficits in the Tau-P301L Mouse ModelLuana Cristina Camargo0Dominik Honold1Robert Bauer2N. Jon Shah3Karl-Josef Langen4Dieter Willbold5Janine Kutzsche6Antje Willuweit7Sarah Schemmert8Institute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, 52425 Jülich, GermanyInstitute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, 52425 Jülich, GermanyInstitute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, 52425 Jülich, GermanyInstitute of Neuroscience and Medicine, Medical Imaging Physics (INM-4), Forschungszentrum Jülich, 52425 Jülich, GermanyInstitute of Neuroscience and Medicine, Medical Imaging Physics (INM-4), Forschungszentrum Jülich, 52425 Jülich, GermanyInstitute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, 52425 Jülich, GermanyInstitute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, 52425 Jülich, GermanyInstitute of Neuroscience and Medicine, Medical Imaging Physics (INM-4), Forschungszentrum Jülich, 52425 Jülich, GermanyInstitute of Biological Information Processing, Structural Biochemistry (IBI-7), Forschungszentrum Jülich, 52425 Jülich, GermanyThe contribution of mouse models for basic and translational research at different levels is important to understand neurodegenerative diseases, including tauopathies, by studying the alterations in the corresponding mouse models in detail. Moreover, several studies demonstrated that pathological as well as behavioral changes are influenced by the sex. For this purpose, we performed an in-depth characterization of the behavioral alterations in the transgenic Tau-P301L mouse model. Sex-matched wild type and homozygous Tau-P301L mice were tested in a battery of behavioral tests at different ages. Tau-P301L male mice showed olfactory and motor deficits as well as increased Tau pathology, which was not observed in Tau-P301L female mice. Both Tau-P301L male and female mice had phenotypic alterations in the SHIRPA test battery and cognitive deficits in the novel object recognition test. This study demonstrated that Tau-P301L mice have phenotypic alterations, which are in line with the histological changes and with a sex-dependent performance in those tests. Summarized, the Tau-P301L mouse model shows phenotypic alterations due to the presence of neurofibrillary tangles in the brain.https://www.mdpi.com/2227-9059/9/9/1160tauopathyTau-P301L mouse modelsbehaviorphosphorylated Taumotor deficitscognitive deficits |
| spellingShingle | Luana Cristina Camargo Dominik Honold Robert Bauer N. Jon Shah Karl-Josef Langen Dieter Willbold Janine Kutzsche Antje Willuweit Sarah Schemmert Sex-Related Motor Deficits in the Tau-P301L Mouse Model Biomedicines tauopathy Tau-P301L mouse models behavior phosphorylated Tau motor deficits cognitive deficits |
| title | Sex-Related Motor Deficits in the Tau-P301L Mouse Model |
| title_full | Sex-Related Motor Deficits in the Tau-P301L Mouse Model |
| title_fullStr | Sex-Related Motor Deficits in the Tau-P301L Mouse Model |
| title_full_unstemmed | Sex-Related Motor Deficits in the Tau-P301L Mouse Model |
| title_short | Sex-Related Motor Deficits in the Tau-P301L Mouse Model |
| title_sort | sex related motor deficits in the tau p301l mouse model |
| topic | tauopathy Tau-P301L mouse models behavior phosphorylated Tau motor deficits cognitive deficits |
| url | https://www.mdpi.com/2227-9059/9/9/1160 |
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