Inter-organ communication involved in metabolic regulation at the whole-body level
Abstract Metabolism in each organ of multi-organ organisms, including humans, is regulated in a coordinated manner to dynamically maintain whole-body homeostasis. Metabolic information exchange among organs/tissues, i.e., inter-organ communication, which is necessary for this purpose, has been a sub...
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | Inflammation and Regeneration |
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| Online Access: | https://doi.org/10.1186/s41232-023-00306-1 |
| _version_ | 1827581780578795520 |
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| author | Hideki Katagiri |
| author_facet | Hideki Katagiri |
| author_sort | Hideki Katagiri |
| collection | DOAJ |
| description | Abstract Metabolism in each organ of multi-organ organisms, including humans, is regulated in a coordinated manner to dynamically maintain whole-body homeostasis. Metabolic information exchange among organs/tissues, i.e., inter-organ communication, which is necessary for this purpose, has been a subject of ongoing research. In particular, it has become clear that metabolism of energy, glucose, lipids, and amino acids is dynamically regulated at the whole-body level mediated by the nervous system, including afferent, central, and efferent nerves. These findings imply that the central nervous system obtains metabolic information from peripheral organs at all times and sends signals selectively to peripheral organs/tissues to maintain metabolic homeostasis, and that the liver plays an important role in sensing and transmitting information on the metabolic status of the body. Furthermore, the utilization of these endogenous mechanisms is expected to lead to the development of novel preventive/curative therapies for metabolic diseases such as diabetes and obesity. (This is a summarized version of the subject matter presented at Symposium 7 presented at the 43rd Annual Meeting of the Japanese Society of Inflammation and Regeneration.) |
| first_indexed | 2024-03-08T22:41:16Z |
| format | Article |
| id | doaj.art-563f0dd070284e3291f8e40cbaf4d134 |
| institution | Directory Open Access Journal |
| issn | 1880-8190 |
| language | English |
| last_indexed | 2024-03-08T22:41:16Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Inflammation and Regeneration |
| spelling | doaj.art-563f0dd070284e3291f8e40cbaf4d1342023-12-17T12:09:50ZengBMCInflammation and Regeneration1880-81902023-12-014311810.1186/s41232-023-00306-1Inter-organ communication involved in metabolic regulation at the whole-body levelHideki Katagiri0Department of Metabolism and Diabetes, Tohoku University Graduate School of MedicineAbstract Metabolism in each organ of multi-organ organisms, including humans, is regulated in a coordinated manner to dynamically maintain whole-body homeostasis. Metabolic information exchange among organs/tissues, i.e., inter-organ communication, which is necessary for this purpose, has been a subject of ongoing research. In particular, it has become clear that metabolism of energy, glucose, lipids, and amino acids is dynamically regulated at the whole-body level mediated by the nervous system, including afferent, central, and efferent nerves. These findings imply that the central nervous system obtains metabolic information from peripheral organs at all times and sends signals selectively to peripheral organs/tissues to maintain metabolic homeostasis, and that the liver plays an important role in sensing and transmitting information on the metabolic status of the body. Furthermore, the utilization of these endogenous mechanisms is expected to lead to the development of novel preventive/curative therapies for metabolic diseases such as diabetes and obesity. (This is a summarized version of the subject matter presented at Symposium 7 presented at the 43rd Annual Meeting of the Japanese Society of Inflammation and Regeneration.)https://doi.org/10.1186/s41232-023-00306-1Inter-organ communicationNeuronal signalsMetabolic homeostasisPancreatic β cells |
| spellingShingle | Hideki Katagiri Inter-organ communication involved in metabolic regulation at the whole-body level Inflammation and Regeneration Inter-organ communication Neuronal signals Metabolic homeostasis Pancreatic β cells |
| title | Inter-organ communication involved in metabolic regulation at the whole-body level |
| title_full | Inter-organ communication involved in metabolic regulation at the whole-body level |
| title_fullStr | Inter-organ communication involved in metabolic regulation at the whole-body level |
| title_full_unstemmed | Inter-organ communication involved in metabolic regulation at the whole-body level |
| title_short | Inter-organ communication involved in metabolic regulation at the whole-body level |
| title_sort | inter organ communication involved in metabolic regulation at the whole body level |
| topic | Inter-organ communication Neuronal signals Metabolic homeostasis Pancreatic β cells |
| url | https://doi.org/10.1186/s41232-023-00306-1 |
| work_keys_str_mv | AT hidekikatagiri interorgancommunicationinvolvedinmetabolicregulationatthewholebodylevel |