Functional Antibody Responses Following Allogeneic Stem Cell Transplantation for TP53 Mutant pre-B-ALL in a Patient With X-Linked Agammaglobulinemia

Functional Antibody Responses Following Allogeneic Stem Cell Transplantation for TP53 Mutant pre-B-ALL in a Patient With X-Linked Agammaglobulinemia

Patients with X-linked agammaglobulinemia (XLA) have failure of B-cell development with lack of immunoglobulin (Ig) production. While immunoglobulin replacement therapy (IgRT) is beneficial, XLA patients remain at risk for infections, structural lung damage, and rarely, neoplasia. Allogeneic stem ce...

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Bibliographic Details
Main Authors: Menno C. van Zelm, Marsus Pumar, Peter Shuttleworth, Pei M. Aui, Joanne M. Smart, Andrew Grigg, Julian J. Bosco
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
X-linked agammaglobulinemia
allogeneic stem cell transplantation
pre-B-ALL
BTK
IgG
vaccination response
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00895/full

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