Plasma concentrations of extracellular matrix protein fibulin-1 are related to cardiovascular risk markers in chronic kidney disease and diabetes
<p>Abstract</p> <p>Background</p> <p>Fibulin-1 is one of a few extracellular matrix proteins present in blood in high concentrations. We aimed to define the relationship between plasma fibulin-1 levels and risk markers of cardiovascular disease.</p> <p>Metho...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2013-01-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | http://www.cardiab.com/content/12/1/6 |
| _version_ | 1818147894953246720 |
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| author | Scholze Alexandra Bladbjerg Else-Marie Sidelmann Johannes J Diederichsen Axel CP Mickley Hans Nybo Mads Argraves W Scott Marckmann Peter Rasmussen Lars M |
| author_facet | Scholze Alexandra Bladbjerg Else-Marie Sidelmann Johannes J Diederichsen Axel CP Mickley Hans Nybo Mads Argraves W Scott Marckmann Peter Rasmussen Lars M |
| author_sort | Scholze Alexandra |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Fibulin-1 is one of a few extracellular matrix proteins present in blood in high concentrations. We aimed to define the relationship between plasma fibulin-1 levels and risk markers of cardiovascular disease.</p> <p>Methods</p> <p>Plasma fibulin-1 was determined in subjects with chronic kidney disease (n = 32; median age 62.5, inter-quartile range 51 – 73 years) and 60 age-matched control subjects. Among kidney disease patients serological biomarkers related to cardiovascular disease (fibrinogen, interleukin 6, C-reactive protein) were measured. Arterial applanation tonometry was used to determine central hemodynamic and arterial stiffness indices.</p> <p>Results</p> <p>We observed a positive correlation of fibulin-1 levels with age (r = 0.38; p = 0.033), glycated hemoglobin (r = 0.80; p = 0.003), creatinine (r = 0.35; p = 0.045), and fibrinogen (r = 0.39; p = 0.027). Glomerular filtration rate and fibulin-1 were inversely correlated (r = −0.57; p = 0.022). There was a positive correlation between fibulin-1 and central pulse pressure (r = 0.44; p = 0.011) and central augmentation pressure (r = 0.55; p = 0.001). In a multivariable regression model, diabetes, creatinine, fibrinogen and central augmentation pressure were independent predictors of plasma fibulin-1.</p> <p>Conclusion</p> <p>Increased plasma fibulin-1 levels were associated with diabetes and impaired kidney function. Furthermore, fibulin-1 levels were associated with hemodynamic cardiovascular risk markers. Fibulin-1 is a candidate in the pathogenesis of cardiovascular disease observed in chronic kidney disease and diabetes.</p> |
| first_indexed | 2024-12-11T12:42:30Z |
| format | Article |
| id | doaj.art-56418795f4644790a07bd4e6bb59042e |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-11T12:42:30Z |
| publishDate | 2013-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-56418795f4644790a07bd4e6bb59042e2022-12-22T01:06:55ZengBMCCardiovascular Diabetology1475-28402013-01-01121610.1186/1475-2840-12-6Plasma concentrations of extracellular matrix protein fibulin-1 are related to cardiovascular risk markers in chronic kidney disease and diabetesScholze AlexandraBladbjerg Else-MarieSidelmann Johannes JDiederichsen Axel CPMickley HansNybo MadsArgraves W ScottMarckmann PeterRasmussen Lars M<p>Abstract</p> <p>Background</p> <p>Fibulin-1 is one of a few extracellular matrix proteins present in blood in high concentrations. We aimed to define the relationship between plasma fibulin-1 levels and risk markers of cardiovascular disease.</p> <p>Methods</p> <p>Plasma fibulin-1 was determined in subjects with chronic kidney disease (n = 32; median age 62.5, inter-quartile range 51 – 73 years) and 60 age-matched control subjects. Among kidney disease patients serological biomarkers related to cardiovascular disease (fibrinogen, interleukin 6, C-reactive protein) were measured. Arterial applanation tonometry was used to determine central hemodynamic and arterial stiffness indices.</p> <p>Results</p> <p>We observed a positive correlation of fibulin-1 levels with age (r = 0.38; p = 0.033), glycated hemoglobin (r = 0.80; p = 0.003), creatinine (r = 0.35; p = 0.045), and fibrinogen (r = 0.39; p = 0.027). Glomerular filtration rate and fibulin-1 were inversely correlated (r = −0.57; p = 0.022). There was a positive correlation between fibulin-1 and central pulse pressure (r = 0.44; p = 0.011) and central augmentation pressure (r = 0.55; p = 0.001). In a multivariable regression model, diabetes, creatinine, fibrinogen and central augmentation pressure were independent predictors of plasma fibulin-1.</p> <p>Conclusion</p> <p>Increased plasma fibulin-1 levels were associated with diabetes and impaired kidney function. Furthermore, fibulin-1 levels were associated with hemodynamic cardiovascular risk markers. Fibulin-1 is a candidate in the pathogenesis of cardiovascular disease observed in chronic kidney disease and diabetes.</p>http://www.cardiab.com/content/12/1/6Fibulin-1Arterial stiffnessCardiovascular diseaseKidney diseaseDiabetes |
| spellingShingle | Scholze Alexandra Bladbjerg Else-Marie Sidelmann Johannes J Diederichsen Axel CP Mickley Hans Nybo Mads Argraves W Scott Marckmann Peter Rasmussen Lars M Plasma concentrations of extracellular matrix protein fibulin-1 are related to cardiovascular risk markers in chronic kidney disease and diabetes Cardiovascular Diabetology Fibulin-1 Arterial stiffness Cardiovascular disease Kidney disease Diabetes |
| title | Plasma concentrations of extracellular matrix protein fibulin-1 are related to cardiovascular risk markers in chronic kidney disease and diabetes |
| title_full | Plasma concentrations of extracellular matrix protein fibulin-1 are related to cardiovascular risk markers in chronic kidney disease and diabetes |
| title_fullStr | Plasma concentrations of extracellular matrix protein fibulin-1 are related to cardiovascular risk markers in chronic kidney disease and diabetes |
| title_full_unstemmed | Plasma concentrations of extracellular matrix protein fibulin-1 are related to cardiovascular risk markers in chronic kidney disease and diabetes |
| title_short | Plasma concentrations of extracellular matrix protein fibulin-1 are related to cardiovascular risk markers in chronic kidney disease and diabetes |
| title_sort | plasma concentrations of extracellular matrix protein fibulin 1 are related to cardiovascular risk markers in chronic kidney disease and diabetes |
| topic | Fibulin-1 Arterial stiffness Cardiovascular disease Kidney disease Diabetes |
| url | http://www.cardiab.com/content/12/1/6 |
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