Epidemiology of cerebral palsy in the Republic of Kazakhstan: Incidence and risk factors
Background: There is a paucity of robust data on the incidence and causes of cerebral palsy (CP) in Central Asian countries, while this information is important for planning local healthcare services. This epidemiological study was designed to clear the gap in knowledge on both the incidence of CP a...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402302056X |
| _version_ | 1827957390247460864 |
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| author | Maiya Zhakupova Ardak Nurbakyt Dinara Ospanova Ardak Chuyenbekova Zhanat Kozhekenova Gauhar Dauletova Akmaral Aitmanbetova Maksat Abdikadir Zhilvinas Padaiga Marina Izmailovich Natalya Glushkova Yuliya Semenova |
| author_facet | Maiya Zhakupova Ardak Nurbakyt Dinara Ospanova Ardak Chuyenbekova Zhanat Kozhekenova Gauhar Dauletova Akmaral Aitmanbetova Maksat Abdikadir Zhilvinas Padaiga Marina Izmailovich Natalya Glushkova Yuliya Semenova |
| author_sort | Maiya Zhakupova |
| collection | DOAJ |
| description | Background: There is a paucity of robust data on the incidence and causes of cerebral palsy (CP) in Central Asian countries, while this information is important for planning local healthcare services. This epidemiological study was designed to clear the gap in knowledge on both the incidence of CP and the underlying risk factors in the Republic of Kazakhstan. Methods: This was a retrospective study that comprised two stages. At the first stage, a cross-sectional analysis of CP frequencies was performed on the basis of official statistics obtained from the Republican Center for Health Development. A study with age- and sex-matched controls was carried out at the second stage to elucidate the maternal and neonatal risk factors associated with CP. Results: Mild variability in national CP incidence was observed, ranging from 68.7 to 83.3 per 100,000 population. A number of maternal risk factors were significantly associated with CP, including arterial hypertension, thrombocytopenia, diabetes mellitus, pathology of fetal membranes, premature rupture of membranes, and acute respiratory illness during pregnancy. Low Apgar score, gestational age, birth weight, and presence of intraventricular hemorrhage or periventricular leukomalacia were among the important neonatal risk factors. Conclusion: There is a need for a more comprehensive prospective study to document the extent of the CP problem in Kazakhstan. In addition, a national CP registry must be envisaged to overcome the lack of essential data. |
| first_indexed | 2024-04-09T15:19:14Z |
| format | Article |
| id | doaj.art-56420e9acdb844de98a2af7870b8efd5 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-09T15:19:14Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-56420e9acdb844de98a2af7870b8efd52023-04-29T14:51:17ZengElsevierHeliyon2405-84402023-04-0194e14849Epidemiology of cerebral palsy in the Republic of Kazakhstan: Incidence and risk factorsMaiya Zhakupova0Ardak Nurbakyt1Dinara Ospanova2Ardak Chuyenbekova3Zhanat Kozhekenova4Gauhar Dauletova5Akmaral Aitmanbetova6Maksat Abdikadir7Zhilvinas Padaiga8Marina Izmailovich9Natalya Glushkova10Yuliya Semenova11Department of Public Health, Asfendiyarov Kazakh National Medical University, Almaty, KazakhstanDepartment of Public Health, Asfendiyarov Kazakh National Medical University, Almaty, KazakhstanDepartment of Epidemiology, Biostatistics and Evidence-Based Medicine, Al-Farabi Kazakh National University, Almaty, KazakhstanDepartment of Nutrition, Asfendiyarov Kazakh National Medical University, Almaty, KazakhstanDepartment of Public Health, Asfendiyarov Kazakh National Medical University, Almaty, KazakhstanDepartment of Public Health, Astana Medical University, Astana, KazakhstanDepartment of Public Health, Asfendiyarov Kazakh National Medical University, Almaty, KazakhstanDepartment of Population Health and Social Sciences, Kazakhstan Medical University School of Public Health, Almaty, KazakhstanLithuanian University of Health Sciences (LSMU), Kaunas, LithuaniaDepartment of Internal Diseases, Karaganda Medical University, Karaganda, KazakhstanDepartment of Epidemiology, Biostatistics and Evidence-Based Medicine, Al-Farabi Kazakh National University, Almaty, KazakhstanNazarbayev University School of Medicine Astana, Kazakhstan; Corresponding author.Background: There is a paucity of robust data on the incidence and causes of cerebral palsy (CP) in Central Asian countries, while this information is important for planning local healthcare services. This epidemiological study was designed to clear the gap in knowledge on both the incidence of CP and the underlying risk factors in the Republic of Kazakhstan. Methods: This was a retrospective study that comprised two stages. At the first stage, a cross-sectional analysis of CP frequencies was performed on the basis of official statistics obtained from the Republican Center for Health Development. A study with age- and sex-matched controls was carried out at the second stage to elucidate the maternal and neonatal risk factors associated with CP. Results: Mild variability in national CP incidence was observed, ranging from 68.7 to 83.3 per 100,000 population. A number of maternal risk factors were significantly associated with CP, including arterial hypertension, thrombocytopenia, diabetes mellitus, pathology of fetal membranes, premature rupture of membranes, and acute respiratory illness during pregnancy. Low Apgar score, gestational age, birth weight, and presence of intraventricular hemorrhage or periventricular leukomalacia were among the important neonatal risk factors. Conclusion: There is a need for a more comprehensive prospective study to document the extent of the CP problem in Kazakhstan. In addition, a national CP registry must be envisaged to overcome the lack of essential data.http://www.sciencedirect.com/science/article/pii/S240584402302056XCerebral palsyIncidenceRisk factorsChildrenKazakhstan |
| spellingShingle | Maiya Zhakupova Ardak Nurbakyt Dinara Ospanova Ardak Chuyenbekova Zhanat Kozhekenova Gauhar Dauletova Akmaral Aitmanbetova Maksat Abdikadir Zhilvinas Padaiga Marina Izmailovich Natalya Glushkova Yuliya Semenova Epidemiology of cerebral palsy in the Republic of Kazakhstan: Incidence and risk factors Heliyon Cerebral palsy Incidence Risk factors Children Kazakhstan |
| title | Epidemiology of cerebral palsy in the Republic of Kazakhstan: Incidence and risk factors |
| title_full | Epidemiology of cerebral palsy in the Republic of Kazakhstan: Incidence and risk factors |
| title_fullStr | Epidemiology of cerebral palsy in the Republic of Kazakhstan: Incidence and risk factors |
| title_full_unstemmed | Epidemiology of cerebral palsy in the Republic of Kazakhstan: Incidence and risk factors |
| title_short | Epidemiology of cerebral palsy in the Republic of Kazakhstan: Incidence and risk factors |
| title_sort | epidemiology of cerebral palsy in the republic of kazakhstan incidence and risk factors |
| topic | Cerebral palsy Incidence Risk factors Children Kazakhstan |
| url | http://www.sciencedirect.com/science/article/pii/S240584402302056X |
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