The cytokine polymorphisms affecting Th1/Th2 increase the susceptibility to, and severity of, chronic ITP

The cytokine polymorphisms affecting Th1/Th2 increase the susceptibility to, and severity of, chronic ITP

Abstract Background T-helper cell type 1 (Th1) polarization in chronic immune thrombocytopenia (cITP) has been reported at the protein and mRNA levels. We evaluated the impact of Th1/Th2 cytokine and cytokine receptor functional polymorphisms on both susceptibility to, and severity of, cITP. We anal...

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Bibliographic Details
Main Authors: Noriyuki Takahashi, Takayuki Saitoh, Nanami Gotoh, Yasuhiro Nitta, Lobna Alkebsi, Tetsuhiro Kasamatsu, Yusuke Minato, Akihiko Yokohama, Norifumi Tsukamoto, Hiroshi Handa, Hirokazu Murakami
Format: Article
Language:English
Published: BMC 2017-05-01
Series:BMC Immunology
Subjects:
Immune thrombocytopenic purpura
Polymorphism
Th1 cells
Cytokine
Cytokine receptor
Online Access:http://link.springer.com/article/10.1186/s12865-017-0210-3

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