Electrospun Biomimetic Nanofibrous Scaffolds: A Promising Prospect for Bone Tissue Engineering and Regenerative Medicine
Skeletal-related disorders such as arthritis, bone cancer, osteosarcoma, and osteoarthritis are among the most common reasons for mortality in humans at present. Nanostructured scaffolds have been discovered to be more efficient for bone regeneration than macro/micro-sized scaffolds because they suf...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/16/9206 |
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| author | Shabnam Anjum Farheen Rahman Prashant Pandey Dilip Kumar Arya Mahmood Alam Paruvathanahalli Siddalingam Rajinikanth Qiang Ao |
| author_facet | Shabnam Anjum Farheen Rahman Prashant Pandey Dilip Kumar Arya Mahmood Alam Paruvathanahalli Siddalingam Rajinikanth Qiang Ao |
| author_sort | Shabnam Anjum |
| collection | DOAJ |
| description | Skeletal-related disorders such as arthritis, bone cancer, osteosarcoma, and osteoarthritis are among the most common reasons for mortality in humans at present. Nanostructured scaffolds have been discovered to be more efficient for bone regeneration than macro/micro-sized scaffolds because they sufficiently permit cell adhesion, proliferation, and chemical transformation. Nanofibrous scaffolds mimicking artificial extracellular matrices provide a natural environment for tissue regeneration owing to their large surface area, high porosity, and appreciable drug loading capacity. Here, we review recent progress and possible future prospective electrospun nanofibrous scaffolds for bone tissue engineering. Electrospun nanofibrous scaffolds have demonstrated promising potential in bone tissue regeneration using a variety of nanomaterials. This review focused on the crucial role of electrospun nanofibrous scaffolds in biological applications, including drug/growth factor delivery to bone tissue regeneration. Natural and synthetic polymeric nanofibrous scaffolds are extensively inspected to regenerate bone tissue. We focused mainly on the significant impact of nanofibrous composite scaffolds on cell adhesion and function, and different composites of organic/inorganic nanoparticles with nanofiber scaffolds. This analysis provides an overview of nanofibrous scaffold-based bone regeneration strategies; however, the same concepts can be applied to other organ and tissue regeneration tactics. |
| first_indexed | 2024-03-09T09:55:17Z |
| format | Article |
| id | doaj.art-5645d6f3ad434672a54ff95155e4df45 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T09:55:17Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-5645d6f3ad434672a54ff95155e4df452023-12-01T23:47:52ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-08-012316920610.3390/ijms23169206Electrospun Biomimetic Nanofibrous Scaffolds: A Promising Prospect for Bone Tissue Engineering and Regenerative MedicineShabnam Anjum0Farheen Rahman1Prashant Pandey2Dilip Kumar Arya3Mahmood Alam4Paruvathanahalli Siddalingam Rajinikanth5Qiang Ao6Department of Tissue Engineering, School of Intelligent Medicine, China Medical University, Shenyang 110122, ChinaDepartment of Applied Chemistry, Zakir Husain College of Engineering & Technology, Aligarh Muslim University, Aligarh 202002, IndiaDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow 226025, IndiaDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow 226025, IndiaDepartment of Clinical Medicine, China Medical University, Shenyang 110122, ChinaDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow 226025, IndiaDepartment of Tissue Engineering, School of Intelligent Medicine, China Medical University, Shenyang 110122, ChinaSkeletal-related disorders such as arthritis, bone cancer, osteosarcoma, and osteoarthritis are among the most common reasons for mortality in humans at present. Nanostructured scaffolds have been discovered to be more efficient for bone regeneration than macro/micro-sized scaffolds because they sufficiently permit cell adhesion, proliferation, and chemical transformation. Nanofibrous scaffolds mimicking artificial extracellular matrices provide a natural environment for tissue regeneration owing to their large surface area, high porosity, and appreciable drug loading capacity. Here, we review recent progress and possible future prospective electrospun nanofibrous scaffolds for bone tissue engineering. Electrospun nanofibrous scaffolds have demonstrated promising potential in bone tissue regeneration using a variety of nanomaterials. This review focused on the crucial role of electrospun nanofibrous scaffolds in biological applications, including drug/growth factor delivery to bone tissue regeneration. Natural and synthetic polymeric nanofibrous scaffolds are extensively inspected to regenerate bone tissue. We focused mainly on the significant impact of nanofibrous composite scaffolds on cell adhesion and function, and different composites of organic/inorganic nanoparticles with nanofiber scaffolds. This analysis provides an overview of nanofibrous scaffold-based bone regeneration strategies; however, the same concepts can be applied to other organ and tissue regeneration tactics.https://www.mdpi.com/1422-0067/23/16/9206bone tissue regenerationnanofibrous scaffoldselectrospinningnanofiber compositebone defectsgrowth factor |
| spellingShingle | Shabnam Anjum Farheen Rahman Prashant Pandey Dilip Kumar Arya Mahmood Alam Paruvathanahalli Siddalingam Rajinikanth Qiang Ao Electrospun Biomimetic Nanofibrous Scaffolds: A Promising Prospect for Bone Tissue Engineering and Regenerative Medicine International Journal of Molecular Sciences bone tissue regeneration nanofibrous scaffolds electrospinning nanofiber composite bone defects growth factor |
| title | Electrospun Biomimetic Nanofibrous Scaffolds: A Promising Prospect for Bone Tissue Engineering and Regenerative Medicine |
| title_full | Electrospun Biomimetic Nanofibrous Scaffolds: A Promising Prospect for Bone Tissue Engineering and Regenerative Medicine |
| title_fullStr | Electrospun Biomimetic Nanofibrous Scaffolds: A Promising Prospect for Bone Tissue Engineering and Regenerative Medicine |
| title_full_unstemmed | Electrospun Biomimetic Nanofibrous Scaffolds: A Promising Prospect for Bone Tissue Engineering and Regenerative Medicine |
| title_short | Electrospun Biomimetic Nanofibrous Scaffolds: A Promising Prospect for Bone Tissue Engineering and Regenerative Medicine |
| title_sort | electrospun biomimetic nanofibrous scaffolds a promising prospect for bone tissue engineering and regenerative medicine |
| topic | bone tissue regeneration nanofibrous scaffolds electrospinning nanofiber composite bone defects growth factor |
| url | https://www.mdpi.com/1422-0067/23/16/9206 |
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