A follow-up study on factors affecting the recovery of patients with hypothyroidism in different selenium environments
Abstract Background Hypothyroidism is a major manifestation of autoimmune thyroid diseases (AITD). We previously reported that a low selenium (Se) status was linked to an elevated prevalence of thyroid diseases. We hypothesized that Se status may also influence the restoration of thyroid function. T...
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| Format: | Article |
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BMC
2024-01-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-024-01536-1 |
| _version_ | 1797274297591398400 |
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| author | Si Wang Ping Chen Yayi He Jing Wei Li Tian Yajun Wu Hongjun Lv Xiaogang Peng Xingru Zhang Bingyin Shi Qian Wu |
| author_facet | Si Wang Ping Chen Yayi He Jing Wei Li Tian Yajun Wu Hongjun Lv Xiaogang Peng Xingru Zhang Bingyin Shi Qian Wu |
| author_sort | Si Wang |
| collection | DOAJ |
| description | Abstract Background Hypothyroidism is a major manifestation of autoimmune thyroid diseases (AITD). We previously reported that a low selenium (Se) status was linked to an elevated prevalence of thyroid diseases. We hypothesized that Se status may also influence the restoration of thyroid function. Thus, this study aimed to investigate the factors affecting the recovery of thyroid function in patients with (sub-)clinical hypothyroidism, with a specific focus on Se status. Methods We conducted a 6-year prospective cohort study comparing two counties with different Se concentrations. Demographic and disease data were collected from 1,190 individuals (549 Se-adequate and 641 Se-deficient) who completed a follow-up study in 2019. In addition, urinary iodine (I) levels, thyroid function, and serum and nail Se levels were measured. Logistic regression was used to investigate the relationship between Se deficiency and recovery of thyroid function. Results Sex and smoking status was similar between the two counties studied. Thyroid function recovery rate was significantly higher in Se-deficient counties (46.0% vs. 30.6%, P = 0.008). In the multivariate analysis, our results show that female sex (odds ratio [OR] (95% confidence interval [CI]) = 1.875 (1.080–3.257), P = 0.026] and increasing age [OR (95%CI) = 1.028(1.007–1.049), P = 0.009] were associated with the recovery rate. Additionally, our study revealed that while Se status was significant in the univariate analysis, this association appeared to disappear in the multivariate analysis. Conclusions Female sex and increasing age have unfavorable effects on the recovery of thyroid function in patients over 30 years of age with (sub-) clinical hypothyroidism. |
| first_indexed | 2024-03-07T14:57:23Z |
| format | Article |
| id | doaj.art-564746439e12402a89741b386afbff2c |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-03-07T14:57:23Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-564746439e12402a89741b386afbff2c2024-03-05T19:22:24ZengBMCBMC Endocrine Disorders1472-68232024-01-0124111010.1186/s12902-024-01536-1A follow-up study on factors affecting the recovery of patients with hypothyroidism in different selenium environmentsSi Wang0Ping Chen1Yayi He2Jing Wei3Li Tian4Yajun Wu5Hongjun Lv6Xiaogang Peng7Xingru Zhang8Bingyin Shi9Qian Wu10Department of Epidemiology and Biostatistics, School of Public Health, Xi’an Jiaotong University Health Science CenterEndemic Disease Control Institute of Shaanxi ProvinceDepartment of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University Health Science CenterLizhou District, Guangyuan Central Hospital, Sichuan ProvinceXi’an North HospitalDepartment of Epidemiology and Biostatistics, School of Public Health, Xi’an Jiaotong University Health Science CenterDepartment of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University Health Science CenterNingshan County People’s HospitalDepartment of Epidemiology and Biostatistics, School of Public Health, Xi’an Jiaotong University Health Science CenterDepartment of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University Health Science CenterDepartment of Epidemiology and Biostatistics, School of Public Health, Xi’an Jiaotong University Health Science CenterAbstract Background Hypothyroidism is a major manifestation of autoimmune thyroid diseases (AITD). We previously reported that a low selenium (Se) status was linked to an elevated prevalence of thyroid diseases. We hypothesized that Se status may also influence the restoration of thyroid function. Thus, this study aimed to investigate the factors affecting the recovery of thyroid function in patients with (sub-)clinical hypothyroidism, with a specific focus on Se status. Methods We conducted a 6-year prospective cohort study comparing two counties with different Se concentrations. Demographic and disease data were collected from 1,190 individuals (549 Se-adequate and 641 Se-deficient) who completed a follow-up study in 2019. In addition, urinary iodine (I) levels, thyroid function, and serum and nail Se levels were measured. Logistic regression was used to investigate the relationship between Se deficiency and recovery of thyroid function. Results Sex and smoking status was similar between the two counties studied. Thyroid function recovery rate was significantly higher in Se-deficient counties (46.0% vs. 30.6%, P = 0.008). In the multivariate analysis, our results show that female sex (odds ratio [OR] (95% confidence interval [CI]) = 1.875 (1.080–3.257), P = 0.026] and increasing age [OR (95%CI) = 1.028(1.007–1.049), P = 0.009] were associated with the recovery rate. Additionally, our study revealed that while Se status was significant in the univariate analysis, this association appeared to disappear in the multivariate analysis. Conclusions Female sex and increasing age have unfavorable effects on the recovery of thyroid function in patients over 30 years of age with (sub-) clinical hypothyroidism.https://doi.org/10.1186/s12902-024-01536-1HypothyroidismAITDTrace elementRecoveryMicronutrient |
| spellingShingle | Si Wang Ping Chen Yayi He Jing Wei Li Tian Yajun Wu Hongjun Lv Xiaogang Peng Xingru Zhang Bingyin Shi Qian Wu A follow-up study on factors affecting the recovery of patients with hypothyroidism in different selenium environments BMC Endocrine Disorders Hypothyroidism AITD Trace element Recovery Micronutrient |
| title | A follow-up study on factors affecting the recovery of patients with hypothyroidism in different selenium environments |
| title_full | A follow-up study on factors affecting the recovery of patients with hypothyroidism in different selenium environments |
| title_fullStr | A follow-up study on factors affecting the recovery of patients with hypothyroidism in different selenium environments |
| title_full_unstemmed | A follow-up study on factors affecting the recovery of patients with hypothyroidism in different selenium environments |
| title_short | A follow-up study on factors affecting the recovery of patients with hypothyroidism in different selenium environments |
| title_sort | follow up study on factors affecting the recovery of patients with hypothyroidism in different selenium environments |
| topic | Hypothyroidism AITD Trace element Recovery Micronutrient |
| url | https://doi.org/10.1186/s12902-024-01536-1 |
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