The Effect of Transcutaneous Application of Gaseous CO<sub>2</sub> on Diabetic Symmetrical Peripheral Neuropathy—A Double-Blind Randomized Clinical Trial
Aim: Diabetic symmetrical peripheral neuropathy is a common complication of diabetes mellitus. Patients treated with transcutaneous CO<sub>2</sub> application for chronic wounds reported an improvement in peripheral sensations. This study aimed to evaluate the effect of transcutaneous ap...
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MDPI AG
2021-05-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/11/11/4911 |
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| author | Helena Ban Frangež Zoran Rodi Jana Miklavčič Igor Frangež |
| author_facet | Helena Ban Frangež Zoran Rodi Jana Miklavčič Igor Frangež |
| author_sort | Helena Ban Frangež |
| collection | DOAJ |
| description | Aim: Diabetic symmetrical peripheral neuropathy is a common complication of diabetes mellitus. Patients treated with transcutaneous CO<sub>2</sub> application for chronic wounds reported an improvement in peripheral sensations. This study aimed to evaluate the effect of transcutaneous application of gaseous CO<sub>2</sub> on diabetic symmetrical peripheral neuropathy. Methods: A prospective randomized, double-blind study was performed at the University Medical Center Ljubljana between September 2019 and September 2020. Sixty consecutive patients with diabetes with a unilateral chronic wound were randomized into either a study group that received transcutaneous CO<sub>2</sub> therapy or a control group that received placebo treatment with air. Results: Vibration, monofilament sensation, and temperature of the big toe improved significantly in the study group (<i>p</i> < 0.001, for vibration sensation, monofilament test and temperature of the big toe), but not in the control group (<i>p</i> = ns for all evaluated outcomes). Conclusion: According to our results, a transcutaneous application of gaseous CO<sub>2</sub> shows promising results in treating diabetic symmetrical peripheral neuropathy. Considering the major consequences of sensory loss leading to foot ulceration and possibly amputation, we believe this treatment approach deserves future attention and investigation as a treatment modality of diabetic symmetrical peripheral neuropathy. |
| first_indexed | 2024-03-10T11:00:23Z |
| format | Article |
| id | doaj.art-56477db889f24ace8003dc336f5d4cd5 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T11:00:23Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-56477db889f24ace8003dc336f5d4cd52023-11-21T21:33:12ZengMDPI AGApplied Sciences2076-34172021-05-011111491110.3390/app11114911The Effect of Transcutaneous Application of Gaseous CO<sub>2</sub> on Diabetic Symmetrical Peripheral Neuropathy—A Double-Blind Randomized Clinical TrialHelena Ban Frangež0Zoran Rodi1Jana Miklavčič2Igor Frangež3Department of Obstetrics and Gynaecology, University Medical Center Ljubljana, Slajmerjeva ul. 3, 1000 Ljubljana, SloveniaInstitute for Clinical Neurophysiology, University Medical Center Ljubljana, Zaloska c. 2, 1000 Ljubljana, SloveniaDepartment of Surgical Infections, University Medical Center Ljubljana, Zaloska c. 2, 1000 Ljubljana, SloveniaFaculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, SloveniaAim: Diabetic symmetrical peripheral neuropathy is a common complication of diabetes mellitus. Patients treated with transcutaneous CO<sub>2</sub> application for chronic wounds reported an improvement in peripheral sensations. This study aimed to evaluate the effect of transcutaneous application of gaseous CO<sub>2</sub> on diabetic symmetrical peripheral neuropathy. Methods: A prospective randomized, double-blind study was performed at the University Medical Center Ljubljana between September 2019 and September 2020. Sixty consecutive patients with diabetes with a unilateral chronic wound were randomized into either a study group that received transcutaneous CO<sub>2</sub> therapy or a control group that received placebo treatment with air. Results: Vibration, monofilament sensation, and temperature of the big toe improved significantly in the study group (<i>p</i> < 0.001, for vibration sensation, monofilament test and temperature of the big toe), but not in the control group (<i>p</i> = ns for all evaluated outcomes). Conclusion: According to our results, a transcutaneous application of gaseous CO<sub>2</sub> shows promising results in treating diabetic symmetrical peripheral neuropathy. Considering the major consequences of sensory loss leading to foot ulceration and possibly amputation, we believe this treatment approach deserves future attention and investigation as a treatment modality of diabetic symmetrical peripheral neuropathy.https://www.mdpi.com/2076-3417/11/11/4911diabetic peripheral neuropathycarboxytherapyCO<sub>2</sub> therapydiabetic foottranscutaneous CO<sub>2</sub> therapy |
| spellingShingle | Helena Ban Frangež Zoran Rodi Jana Miklavčič Igor Frangež The Effect of Transcutaneous Application of Gaseous CO<sub>2</sub> on Diabetic Symmetrical Peripheral Neuropathy—A Double-Blind Randomized Clinical Trial Applied Sciences diabetic peripheral neuropathy carboxytherapy CO<sub>2</sub> therapy diabetic foot transcutaneous CO<sub>2</sub> therapy |
| title | The Effect of Transcutaneous Application of Gaseous CO<sub>2</sub> on Diabetic Symmetrical Peripheral Neuropathy—A Double-Blind Randomized Clinical Trial |
| title_full | The Effect of Transcutaneous Application of Gaseous CO<sub>2</sub> on Diabetic Symmetrical Peripheral Neuropathy—A Double-Blind Randomized Clinical Trial |
| title_fullStr | The Effect of Transcutaneous Application of Gaseous CO<sub>2</sub> on Diabetic Symmetrical Peripheral Neuropathy—A Double-Blind Randomized Clinical Trial |
| title_full_unstemmed | The Effect of Transcutaneous Application of Gaseous CO<sub>2</sub> on Diabetic Symmetrical Peripheral Neuropathy—A Double-Blind Randomized Clinical Trial |
| title_short | The Effect of Transcutaneous Application of Gaseous CO<sub>2</sub> on Diabetic Symmetrical Peripheral Neuropathy—A Double-Blind Randomized Clinical Trial |
| title_sort | effect of transcutaneous application of gaseous co sub 2 sub on diabetic symmetrical peripheral neuropathy a double blind randomized clinical trial |
| topic | diabetic peripheral neuropathy carboxytherapy CO<sub>2</sub> therapy diabetic foot transcutaneous CO<sub>2</sub> therapy |
| url | https://www.mdpi.com/2076-3417/11/11/4911 |
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