Serum copeptin might improve risk stratification and management of aortic valve stenosis: a review of pathophysiological insights and practical implications
Over recent decades, the prevalence of aortic valve stenosis (AVS) has been constantly increasing possibly owing to the aging of general population. Severe AVS as determined by an aortic valve area (AVA) of <1 cm 2 has been regarded as a serious clinical condition potentially associated with a va...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-02-01
|
| Series: | Therapeutic Advances in Cardiovascular Disease |
| Online Access: | https://doi.org/10.1177/1753944719826420 |
| _version_ | 1818043050656530432 |
|---|---|
| author | Kenan Yalta Orkide Palabiyik Muhammet Gurdogan Yekta Gurlertop |
| author_facet | Kenan Yalta Orkide Palabiyik Muhammet Gurdogan Yekta Gurlertop |
| author_sort | Kenan Yalta |
| collection | DOAJ |
| description | Over recent decades, the prevalence of aortic valve stenosis (AVS) has been constantly increasing possibly owing to the aging of general population. Severe AVS as determined by an aortic valve area (AVA) of <1 cm 2 has been regarded as a serious clinical condition potentially associated with a variety of adverse outcomes, including sudden cardiac death (SCD). However, patients with severe AVS (in the absence of overt high-risk features) are usually evaluated and managed exclusively based on symptomatology or imperfect prognostic tools including exercise testing and biomarkers, with a potential risk of mismanagement, suggesting the need for further objective risk stratifiers in this setting. Within this context, copeptin (C-terminal pro-vasopressin), a novel neurohormone widely considered as the surrogate marker of the arginine–vasopressin (AVP) system, may potentially serve as a reliable prognostic and therapeutic guide (e.g. timing of aortic valvular intervention) in patients with severe AVS largely based on its hemodynamic, fibrogenic as well as autonomic implications in these patients. Accordingly, the present paper aims to discuss clinical and pathophysiological implications of copeptin in the setting of AVS along with a summary of biomarkers and other prognostic tools used in this setting. |
| first_indexed | 2024-12-10T08:56:03Z |
| format | Article |
| id | doaj.art-564794664c6142b7b2ce6ef6e8de084c |
| institution | Directory Open Access Journal |
| issn | 1753-9455 |
| language | English |
| last_indexed | 2024-12-10T08:56:03Z |
| publishDate | 2019-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Cardiovascular Disease |
| spelling | doaj.art-564794664c6142b7b2ce6ef6e8de084c2022-12-22T01:55:26ZengSAGE PublishingTherapeutic Advances in Cardiovascular Disease1753-94552019-02-011310.1177/1753944719826420Serum copeptin might improve risk stratification and management of aortic valve stenosis: a review of pathophysiological insights and practical implicationsKenan YaltaOrkide PalabiyikMuhammet GurdoganYekta GurlertopOver recent decades, the prevalence of aortic valve stenosis (AVS) has been constantly increasing possibly owing to the aging of general population. Severe AVS as determined by an aortic valve area (AVA) of <1 cm 2 has been regarded as a serious clinical condition potentially associated with a variety of adverse outcomes, including sudden cardiac death (SCD). However, patients with severe AVS (in the absence of overt high-risk features) are usually evaluated and managed exclusively based on symptomatology or imperfect prognostic tools including exercise testing and biomarkers, with a potential risk of mismanagement, suggesting the need for further objective risk stratifiers in this setting. Within this context, copeptin (C-terminal pro-vasopressin), a novel neurohormone widely considered as the surrogate marker of the arginine–vasopressin (AVP) system, may potentially serve as a reliable prognostic and therapeutic guide (e.g. timing of aortic valvular intervention) in patients with severe AVS largely based on its hemodynamic, fibrogenic as well as autonomic implications in these patients. Accordingly, the present paper aims to discuss clinical and pathophysiological implications of copeptin in the setting of AVS along with a summary of biomarkers and other prognostic tools used in this setting.https://doi.org/10.1177/1753944719826420 |
| spellingShingle | Kenan Yalta Orkide Palabiyik Muhammet Gurdogan Yekta Gurlertop Serum copeptin might improve risk stratification and management of aortic valve stenosis: a review of pathophysiological insights and practical implications Therapeutic Advances in Cardiovascular Disease |
| title | Serum copeptin might improve risk stratification and management of aortic valve stenosis: a review of pathophysiological insights and practical implications |
| title_full | Serum copeptin might improve risk stratification and management of aortic valve stenosis: a review of pathophysiological insights and practical implications |
| title_fullStr | Serum copeptin might improve risk stratification and management of aortic valve stenosis: a review of pathophysiological insights and practical implications |
| title_full_unstemmed | Serum copeptin might improve risk stratification and management of aortic valve stenosis: a review of pathophysiological insights and practical implications |
| title_short | Serum copeptin might improve risk stratification and management of aortic valve stenosis: a review of pathophysiological insights and practical implications |
| title_sort | serum copeptin might improve risk stratification and management of aortic valve stenosis a review of pathophysiological insights and practical implications |
| url | https://doi.org/10.1177/1753944719826420 |
| work_keys_str_mv | AT kenanyalta serumcopeptinmightimproveriskstratificationandmanagementofaorticvalvestenosisareviewofpathophysiologicalinsightsandpracticalimplications AT orkidepalabiyik serumcopeptinmightimproveriskstratificationandmanagementofaorticvalvestenosisareviewofpathophysiologicalinsightsandpracticalimplications AT muhammetgurdogan serumcopeptinmightimproveriskstratificationandmanagementofaorticvalvestenosisareviewofpathophysiologicalinsightsandpracticalimplications AT yektagurlertop serumcopeptinmightimproveriskstratificationandmanagementofaorticvalvestenosisareviewofpathophysiologicalinsightsandpracticalimplications |