Rapidly Destructive Coxarthrosis as a Potential Side Effect of Crizotinib in a Patient with ROS1-Positive Lung Adenocarcinoma
Shinkichi Takamori, 1 Takashi Seto, 1 Mikako Jinnouchi, 2 Taro Oba, 1 Masafumi Yamaguchi, 1 Mitsuhiro Takenoyama 1 1Department of Thoracic Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka 811-1395, Japan; 2Department of Radiology, National Hospital Organization Kyushu Cancer...
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| Format: | Article |
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Dove Medical Press
2020-01-01
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| Series: | Therapeutics and Clinical Risk Management |
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| Online Access: | https://www.dovepress.com/rapidly-destructive-coxarthrosis-as-a-potential-side-effect-of-crizoti-peer-reviewed-article-TCRM |
| _version_ | 1818696201650831360 |
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| author | Takamori S Seto T Jinnouchi M Oba T Yamaguchi M Takenoyama M |
| author_facet | Takamori S Seto T Jinnouchi M Oba T Yamaguchi M Takenoyama M |
| author_sort | Takamori S |
| collection | DOAJ |
| description | Shinkichi Takamori, 1 Takashi Seto, 1 Mikako Jinnouchi, 2 Taro Oba, 1 Masafumi Yamaguchi, 1 Mitsuhiro Takenoyama 1 1Department of Thoracic Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka 811-1395, Japan; 2Department of Radiology, National Hospital Organization Kyushu Cancer Center, Fukuoka 811-1395, JapanCorrespondence: Takashi SetoDepartment of Thoracic Oncology, National Hospital Organization Kyushu Cancer Center, 3-1-1 Notame, Minami-Ku, Fukuoka 811-1395, JapanTel +81 92 541 3231Fax +81 92 551 4585Email setocruise@gmail.comAbstract: A 75-year-old woman was diagnosed with c-ros oncogene 1 (ROS1)-positive lung adenocarcinoma. She was treated with crizotinib 750 mg/day for 4.5 years, with partial tumor response. However, the patient subsequently presented with right hip pain and difficulty in walking. She underwent magnetic resonance imaging (MRI), which detected T2 prolongation in the right femoral bone head, synovial fluid retention, and bone joint fissure narrowing. The patient was diagnosed with rapidly destructive coxarthrosis (RDC) and received a total hip arthroplasty. This represents a rare case of RDC as a potential side effect of crizotinib in a patient with ROS1-positive lung adenocarcinoma. MRI should therefore be recommended in patients receiving crizotinib who experience continuing severe hip pain and difficulty in walking. Further investigations are warranted to elucidate the pathogenesis of RDC associated with crizotinib treatment.Keywords: non-small cell lung cancer, ROS1, crizotinib, rapidly destructive coxarthrosis |
| first_indexed | 2024-12-17T13:57:36Z |
| format | Article |
| id | doaj.art-5647ec1218e14921a67367425c4bdbce |
| institution | Directory Open Access Journal |
| issn | 1178-203X |
| language | English |
| last_indexed | 2024-12-17T13:57:36Z |
| publishDate | 2020-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Therapeutics and Clinical Risk Management |
| spelling | doaj.art-5647ec1218e14921a67367425c4bdbce2022-12-21T21:45:52ZengDove Medical PressTherapeutics and Clinical Risk Management1178-203X2020-01-01Volume 16172051216Rapidly Destructive Coxarthrosis as a Potential Side Effect of Crizotinib in a Patient with ROS1-Positive Lung AdenocarcinomaTakamori SSeto TJinnouchi MOba TYamaguchi MTakenoyama MShinkichi Takamori, 1 Takashi Seto, 1 Mikako Jinnouchi, 2 Taro Oba, 1 Masafumi Yamaguchi, 1 Mitsuhiro Takenoyama 1 1Department of Thoracic Oncology, National Hospital Organization Kyushu Cancer Center, Fukuoka 811-1395, Japan; 2Department of Radiology, National Hospital Organization Kyushu Cancer Center, Fukuoka 811-1395, JapanCorrespondence: Takashi SetoDepartment of Thoracic Oncology, National Hospital Organization Kyushu Cancer Center, 3-1-1 Notame, Minami-Ku, Fukuoka 811-1395, JapanTel +81 92 541 3231Fax +81 92 551 4585Email setocruise@gmail.comAbstract: A 75-year-old woman was diagnosed with c-ros oncogene 1 (ROS1)-positive lung adenocarcinoma. She was treated with crizotinib 750 mg/day for 4.5 years, with partial tumor response. However, the patient subsequently presented with right hip pain and difficulty in walking. She underwent magnetic resonance imaging (MRI), which detected T2 prolongation in the right femoral bone head, synovial fluid retention, and bone joint fissure narrowing. The patient was diagnosed with rapidly destructive coxarthrosis (RDC) and received a total hip arthroplasty. This represents a rare case of RDC as a potential side effect of crizotinib in a patient with ROS1-positive lung adenocarcinoma. MRI should therefore be recommended in patients receiving crizotinib who experience continuing severe hip pain and difficulty in walking. Further investigations are warranted to elucidate the pathogenesis of RDC associated with crizotinib treatment.Keywords: non-small cell lung cancer, ROS1, crizotinib, rapidly destructive coxarthrosishttps://www.dovepress.com/rapidly-destructive-coxarthrosis-as-a-potential-side-effect-of-crizoti-peer-reviewed-article-TCRMnon-small cell lung cancerros1crizotinibrapidly destructive coxarthrosis |
| spellingShingle | Takamori S Seto T Jinnouchi M Oba T Yamaguchi M Takenoyama M Rapidly Destructive Coxarthrosis as a Potential Side Effect of Crizotinib in a Patient with ROS1-Positive Lung Adenocarcinoma Therapeutics and Clinical Risk Management non-small cell lung cancer ros1 crizotinib rapidly destructive coxarthrosis |
| title | Rapidly Destructive Coxarthrosis as a Potential Side Effect of Crizotinib in a Patient with ROS1-Positive Lung Adenocarcinoma |
| title_full | Rapidly Destructive Coxarthrosis as a Potential Side Effect of Crizotinib in a Patient with ROS1-Positive Lung Adenocarcinoma |
| title_fullStr | Rapidly Destructive Coxarthrosis as a Potential Side Effect of Crizotinib in a Patient with ROS1-Positive Lung Adenocarcinoma |
| title_full_unstemmed | Rapidly Destructive Coxarthrosis as a Potential Side Effect of Crizotinib in a Patient with ROS1-Positive Lung Adenocarcinoma |
| title_short | Rapidly Destructive Coxarthrosis as a Potential Side Effect of Crizotinib in a Patient with ROS1-Positive Lung Adenocarcinoma |
| title_sort | rapidly destructive coxarthrosis as a potential side effect of crizotinib in a patient with ros1 positive lung adenocarcinoma |
| topic | non-small cell lung cancer ros1 crizotinib rapidly destructive coxarthrosis |
| url | https://www.dovepress.com/rapidly-destructive-coxarthrosis-as-a-potential-side-effect-of-crizoti-peer-reviewed-article-TCRM |
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