Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aβ

Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aβ

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by aberrant amyloid-β (Aβ) and hyperphosphorylated tau aggregation. We have previously investigated the involvement of SEPTIN family members in AD-related cellular processes and discovered a role for SEPTIN8 in the sorting and acc...

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Bibliographic Details
Main Authors: Mikael Marttinen, Catarina B. Ferreira, Kaisa M. A. Paldanius, Mari Takalo, Teemu Natunen, Petra Mäkinen, Luukas Leppänen, Ville Leinonen, Kenji Tanigaki, Gina Kang, Noboru Hiroi, Hilkka Soininen, Kirsi Rilla, Annakaisa Haapasalo, Mikko Hiltunen
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cells
Subjects:
Aβ
Alzheimer’s disease
APP C-terminal fragments
autophagy
SEPTIN5
Online Access:https://www.mdpi.com/2073-4409/9/11/2482

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