Clinical Diagnosis and Perioperative Management of Glioma-Related Epilepsy
Gliomas account for more than half of all adult primary brain tumors. Epilepsy is the most common initial clinical presentation in gliomas. Glioma related epilepsy (GRE) is defined as symptomatic epileptic seizures secondary to gliomas, occurring in nearly 50% in high-grade glioma (HGG) patients and...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.550353/full |
| _version_ | 1818383457625047040 |
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| author | Gan You Zhiyi Sha Tao Jiang |
| author_facet | Gan You Zhiyi Sha Tao Jiang |
| author_sort | Gan You |
| collection | DOAJ |
| description | Gliomas account for more than half of all adult primary brain tumors. Epilepsy is the most common initial clinical presentation in gliomas. Glioma related epilepsy (GRE) is defined as symptomatic epileptic seizures secondary to gliomas, occurring in nearly 50% in high-grade glioma (HGG) patients and up to 90% in patients with low-grade glioma (LGG). Uncontrolled seizures, which have major impact on patients’ quality of life, are caused by multiple factors. Although the anti-seizure medications (ASMs), chemotherapy and radiation therapy are also beneficial for seizure treatment, the overall seizure control for GRE continue to be unsatisfactory. Due to the close relationship between GRE and glioma, surgical resection is often the treatment of choice not only for the tumor treatment, but also for the seizure control. Despite aggressive surgical treatment, there are about 30% of patients continue to have poor seizure control postoperatively. Furthermore, the diagnostic criteria for GRE is not well established. In this review, we propose an algorithm for the diagnosis and perioperative management for GRE. |
| first_indexed | 2024-12-14T03:06:40Z |
| format | Article |
| id | doaj.art-564aad3587334905a157e8906e581d36 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-14T03:06:40Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-564aad3587334905a157e8906e581d362022-12-21T23:19:23ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-01-011010.3389/fonc.2020.550353550353Clinical Diagnosis and Perioperative Management of Glioma-Related EpilepsyGan You0Zhiyi Sha1Tao Jiang2Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Medical School, University of Minnesota, Minneapolis, MN, United StatesDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaGliomas account for more than half of all adult primary brain tumors. Epilepsy is the most common initial clinical presentation in gliomas. Glioma related epilepsy (GRE) is defined as symptomatic epileptic seizures secondary to gliomas, occurring in nearly 50% in high-grade glioma (HGG) patients and up to 90% in patients with low-grade glioma (LGG). Uncontrolled seizures, which have major impact on patients’ quality of life, are caused by multiple factors. Although the anti-seizure medications (ASMs), chemotherapy and radiation therapy are also beneficial for seizure treatment, the overall seizure control for GRE continue to be unsatisfactory. Due to the close relationship between GRE and glioma, surgical resection is often the treatment of choice not only for the tumor treatment, but also for the seizure control. Despite aggressive surgical treatment, there are about 30% of patients continue to have poor seizure control postoperatively. Furthermore, the diagnostic criteria for GRE is not well established. In this review, we propose an algorithm for the diagnosis and perioperative management for GRE.https://www.frontiersin.org/articles/10.3389/fonc.2020.550353/fulldiagnosisepilepsygliomaseizuresurgerytreatment |
| spellingShingle | Gan You Zhiyi Sha Tao Jiang Clinical Diagnosis and Perioperative Management of Glioma-Related Epilepsy Frontiers in Oncology diagnosis epilepsy glioma seizure surgery treatment |
| title | Clinical Diagnosis and Perioperative Management of Glioma-Related Epilepsy |
| title_full | Clinical Diagnosis and Perioperative Management of Glioma-Related Epilepsy |
| title_fullStr | Clinical Diagnosis and Perioperative Management of Glioma-Related Epilepsy |
| title_full_unstemmed | Clinical Diagnosis and Perioperative Management of Glioma-Related Epilepsy |
| title_short | Clinical Diagnosis and Perioperative Management of Glioma-Related Epilepsy |
| title_sort | clinical diagnosis and perioperative management of glioma related epilepsy |
| topic | diagnosis epilepsy glioma seizure surgery treatment |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.550353/full |
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