Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of Fibronectin
The extracellular matrix (ECM) is a complex and specialized three-dimensional macromolecular network, present in nearly all tissues, that also interacts with cell surface receptors on joint resident cells. Changes in the composition and physical properties of the ECM lead to the development of many...
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MDPI AG
2019-12-01
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author | Selene Pérez-García Mar Carrión Irene Gutiérrez-Cañas Raúl Villanueva-Romero David Castro Carmen Martínez Isidoro González-Álvaro Francisco J. Blanco Yasmina Juarranz Rosa P. Gomariz |
author_facet | Selene Pérez-García Mar Carrión Irene Gutiérrez-Cañas Raúl Villanueva-Romero David Castro Carmen Martínez Isidoro González-Álvaro Francisco J. Blanco Yasmina Juarranz Rosa P. Gomariz |
author_sort | Selene Pérez-García |
collection | DOAJ |
description | The extracellular matrix (ECM) is a complex and specialized three-dimensional macromolecular network, present in nearly all tissues, that also interacts with cell surface receptors on joint resident cells. Changes in the composition and physical properties of the ECM lead to the development of many diseases, including osteoarthritis (OA). OA is a chronic degenerative rheumatic disease characterized by a progressive loss of synovial joint function as a consequence of the degradation of articular cartilage, also associated with alterations in the synovial membrane and subchondral bone. During OA, ECM-degrading enzymes, including urokinase-type plasminogen activator (uPA), matrix metalloproteinases (MMPs), and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs), cleave ECM components, such as fibronectin (Fn), generating fibronectin fragments (Fn-fs) with catabolic properties. In turn, Fn-fs promote activation of these proteinases, establishing a degradative and inflammatory feedback loop. Thus, the aim of this review is to update the contribution of ECM-degrading proteinases to the physiopathology of OA as well as their modulation by Fn-fs. |
first_indexed | 2024-03-12T10:49:26Z |
format | Article |
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institution | Directory Open Access Journal |
issn | 2073-4409 |
language | English |
last_indexed | 2024-03-12T10:49:26Z |
publishDate | 2019-12-01 |
publisher | MDPI AG |
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series | Cells |
spelling | doaj.art-5651fb7521374710b0e3961636d9c4872023-09-02T07:07:40ZengMDPI AGCells2073-44092019-12-01914010.3390/cells9010040cells9010040Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of FibronectinSelene Pérez-García0Mar Carrión1Irene Gutiérrez-Cañas2Raúl Villanueva-Romero3David Castro4Carmen Martínez5Isidoro González-Álvaro6Francisco J. Blanco7Yasmina Juarranz8Rosa P. Gomariz9Departamento de Biología Celular, Facultad de Biología y Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, SpainDepartamento de Biología Celular, Facultad de Biología y Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, SpainDepartamento de Biología Celular, Facultad de Biología y Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, SpainDepartamento de Biología Celular, Facultad de Biología y Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, SpainDepartamento de Biología Celular, Facultad de Biología y Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, SpainDepartamento de Biología Celular, Facultad de Biología y Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, SpainServicio de Reumatología, Instituto de Investigación Médica, Hospital Universitario La Princesa, 28006 Madrid, SpainServicio de Reumatología, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña, Sergas, Universidade da Coruña (UDC), 15006 A Coruña, SpainDepartamento de Biología Celular, Facultad de Biología y Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, SpainDepartamento de Biología Celular, Facultad de Biología y Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, SpainThe extracellular matrix (ECM) is a complex and specialized three-dimensional macromolecular network, present in nearly all tissues, that also interacts with cell surface receptors on joint resident cells. Changes in the composition and physical properties of the ECM lead to the development of many diseases, including osteoarthritis (OA). OA is a chronic degenerative rheumatic disease characterized by a progressive loss of synovial joint function as a consequence of the degradation of articular cartilage, also associated with alterations in the synovial membrane and subchondral bone. During OA, ECM-degrading enzymes, including urokinase-type plasminogen activator (uPA), matrix metalloproteinases (MMPs), and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs), cleave ECM components, such as fibronectin (Fn), generating fibronectin fragments (Fn-fs) with catabolic properties. In turn, Fn-fs promote activation of these proteinases, establishing a degradative and inflammatory feedback loop. Thus, the aim of this review is to update the contribution of ECM-degrading proteinases to the physiopathology of OA as well as their modulation by Fn-fs.https://www.mdpi.com/2073-4409/9/1/40osteoarthritisfibronectinproteinasesupammpadamts |
spellingShingle | Selene Pérez-García Mar Carrión Irene Gutiérrez-Cañas Raúl Villanueva-Romero David Castro Carmen Martínez Isidoro González-Álvaro Francisco J. Blanco Yasmina Juarranz Rosa P. Gomariz Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of Fibronectin Cells osteoarthritis fibronectin proteinases upa mmp adamts |
title | Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of Fibronectin |
title_full | Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of Fibronectin |
title_fullStr | Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of Fibronectin |
title_full_unstemmed | Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of Fibronectin |
title_short | Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of Fibronectin |
title_sort | profile of matrix remodeling proteinases in osteoarthritis impact of fibronectin |
topic | osteoarthritis fibronectin proteinases upa mmp adamts |
url | https://www.mdpi.com/2073-4409/9/1/40 |
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