Protamine-2 Deficiency Initiates a Reactive Oxygen Species (ROS)-Mediated Destruction Cascade during Epididymal Sperm Maturation in Mice
Protamines are the safeguards of the paternal sperm genome. They replace most of the histones during spermiogenesis, resulting in DNA hypercondensation, thereby protecting its genome from environmental noxa. Impaired protamination has been linked to male infertility in mice and humans in many studie...
Main Authors: | Simon Schneider, Farhad Shakeri, Christian Trötschel, Lena Arévalo, Alexander Kruse, Andreas Buness, Ansgar Poetsch, Klaus Steger, Hubert Schorle |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-07-01
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Series: | Cells |
Subjects: | |
Online Access: | https://www.mdpi.com/2073-4409/9/8/1789 |
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