Protamine-2 Deficiency Initiates a Reactive Oxygen Species (ROS)-Mediated Destruction Cascade during Epididymal Sperm Maturation in Mice

Protamine-2 Deficiency Initiates a Reactive Oxygen Species (ROS)-Mediated Destruction Cascade during Epididymal Sperm Maturation in Mice

Protamines are the safeguards of the paternal sperm genome. They replace most of the histones during spermiogenesis, resulting in DNA hypercondensation, thereby protecting its genome from environmental noxa. Impaired protamination has been linked to male infertility in mice and humans in many studie...

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Bibliographic Details
Main Authors: Simon Schneider, Farhad Shakeri, Christian Trötschel, Lena Arévalo, Alexander Kruse, Andreas Buness, Ansgar Poetsch, Klaus Steger, Hubert Schorle
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cells
Subjects:
protamines
sperm
infertility
ROS
Online Access:https://www.mdpi.com/2073-4409/9/8/1789

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