The effect of intracerebroventricular administration of orexin receptor type 2 antagonist on pentylenetetrazol-induced kindled seizures and anxiety in rats

The effect of intracerebroventricular administration of orexin receptor type 2 antagonist on pentylenetetrazol-induced kindled seizures and anxiety in rats

Abstract Background Current antiepileptic drugs are not able to prevent recurrent seizures in all patients. Orexins are excitatory hypothalamic neuropeptides that their receptors (Orx1R and Orx2R) are found almost in all major regions of the brain. Pentylenetetrazol (PTZ)-induced kindling is a known...

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Bibliographic Details
Main Authors: Saeedeh Asadi, Ali Roohbakhsh, Ali Shamsizadeh, Masoud Fereidoni, Elham Kordijaz, Ali Moghimi
Format: Article
Language:English
Published: BMC 2018-08-01
Series:BMC Neuroscience
Subjects:
Anxiety
Kindling
Orexin
Orx2 receptor
PTZ
Seizure
Online Access:http://link.springer.com/article/10.1186/s12868-018-0445-9

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