Uric acid and neurological disease: a narrative review
Hyperuricemia often accompanies hypertension, diabetes, dyslipidemia, metabolic syndrome, and chronic renal disease; it is also closely related to cardiovascular disease. Moreover, several epidemiological studies have linked hyperuricemia and ischemic stroke. However, uric acid may also have neuropr...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1164756/full |
| _version_ | 1797814072130928640 |
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| author | Naoyuki Otani Eisei Hoshiyama Motoshi Ouchi Hidehiro Takekawa Hidehiro Takekawa Keisuke Suzuki |
| author_facet | Naoyuki Otani Eisei Hoshiyama Motoshi Ouchi Hidehiro Takekawa Hidehiro Takekawa Keisuke Suzuki |
| author_sort | Naoyuki Otani |
| collection | DOAJ |
| description | Hyperuricemia often accompanies hypertension, diabetes, dyslipidemia, metabolic syndrome, and chronic renal disease; it is also closely related to cardiovascular disease. Moreover, several epidemiological studies have linked hyperuricemia and ischemic stroke. However, uric acid may also have neuroprotective effects because of its antioxidant properties. An association between low uric acid levels and neurodegenerative diseases has been suggested, which may be attributed to diminished neuroprotective effects as a result of reduced uric acid. This review will focus on the relationship between uric acid and various neurological diseases including stroke, neuroimmune diseases, and neurodegenerative diseases. When considering both the risk and pathogenesis of neurological diseases, it is important to consider the conflicting dual nature of uric acid as both a vascular risk factor and a neuroprotective factor. This dual nature of uric acid is important because it may help to elucidate the biological role of uric acid in various neurological diseases and provide new insights into the etiology and treatment of these diseases. |
| first_indexed | 2024-03-13T08:02:08Z |
| format | Article |
| id | doaj.art-5654753c890e4f3e837384589b886916 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-03-13T08:02:08Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-5654753c890e4f3e837384589b8869162023-06-01T12:18:08ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-06-011410.3389/fneur.2023.11647561164756Uric acid and neurological disease: a narrative reviewNaoyuki Otani0Eisei Hoshiyama1Motoshi Ouchi2Hidehiro Takekawa3Hidehiro Takekawa4Keisuke Suzuki5Department of Cardiology, Dokkyo Medical University Nikkyo Medical Center, Mibu, JapanDepartment of Neurology, Dokkyo Medical University, Mibu, JapanDepartment of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Mibu, JapanDepartment of Neurology, Dokkyo Medical University, Mibu, JapanStroke Center, Dokkyo Medical University, Mibu, JapanDepartment of Neurology, Dokkyo Medical University, Mibu, JapanHyperuricemia often accompanies hypertension, diabetes, dyslipidemia, metabolic syndrome, and chronic renal disease; it is also closely related to cardiovascular disease. Moreover, several epidemiological studies have linked hyperuricemia and ischemic stroke. However, uric acid may also have neuroprotective effects because of its antioxidant properties. An association between low uric acid levels and neurodegenerative diseases has been suggested, which may be attributed to diminished neuroprotective effects as a result of reduced uric acid. This review will focus on the relationship between uric acid and various neurological diseases including stroke, neuroimmune diseases, and neurodegenerative diseases. When considering both the risk and pathogenesis of neurological diseases, it is important to consider the conflicting dual nature of uric acid as both a vascular risk factor and a neuroprotective factor. This dual nature of uric acid is important because it may help to elucidate the biological role of uric acid in various neurological diseases and provide new insights into the etiology and treatment of these diseases.https://www.frontiersin.org/articles/10.3389/fneur.2023.1164756/fullhyperuricemiauric acidneurological diseasestrokeneurodegenerative disease |
| spellingShingle | Naoyuki Otani Eisei Hoshiyama Motoshi Ouchi Hidehiro Takekawa Hidehiro Takekawa Keisuke Suzuki Uric acid and neurological disease: a narrative review Frontiers in Neurology hyperuricemia uric acid neurological disease stroke neurodegenerative disease |
| title | Uric acid and neurological disease: a narrative review |
| title_full | Uric acid and neurological disease: a narrative review |
| title_fullStr | Uric acid and neurological disease: a narrative review |
| title_full_unstemmed | Uric acid and neurological disease: a narrative review |
| title_short | Uric acid and neurological disease: a narrative review |
| title_sort | uric acid and neurological disease a narrative review |
| topic | hyperuricemia uric acid neurological disease stroke neurodegenerative disease |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1164756/full |
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